King's College London

Research portal

Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants

Research output: Contribution to journalArticlepeer-review

Standard

Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants. / Rokita, Karolina I; Holleran, Laurena; Dauvermann, Maria R; Mothersill, David; Holland, Jessica; Costello, Laura; Kane, Ruán; McKernan, Declan; Morris, Derek W; Kelly, John P; Corvin, Aiden; Hallahan, Brian; McDonald, Colm; Donohoe, Gary.

In: Social Cognitive and Affective Neuroscience, Vol. 15, No. 12, 24.12.2020, p. 1336-1350.

Research output: Contribution to journalArticlepeer-review

Harvard

Rokita, KI, Holleran, L, Dauvermann, MR, Mothersill, D, Holland, J, Costello, L, Kane, R, McKernan, D, Morris, DW, Kelly, JP, Corvin, A, Hallahan, B, McDonald, C & Donohoe, G 2020, 'Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants', Social Cognitive and Affective Neuroscience, vol. 15, no. 12, pp. 1336-1350. https://doi.org/10.1093/scan/nsaa160

APA

Rokita, K. I., Holleran, L., Dauvermann, M. R., Mothersill, D., Holland, J., Costello, L., Kane, R., McKernan, D., Morris, D. W., Kelly, J. P., Corvin, A., Hallahan, B., McDonald, C., & Donohoe, G. (2020). Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants. Social Cognitive and Affective Neuroscience, 15(12), 1336-1350. https://doi.org/10.1093/scan/nsaa160

Vancouver

Rokita KI, Holleran L, Dauvermann MR, Mothersill D, Holland J, Costello L et al. Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants. Social Cognitive and Affective Neuroscience. 2020 Dec 24;15(12):1336-1350. https://doi.org/10.1093/scan/nsaa160

Author

Rokita, Karolina I ; Holleran, Laurena ; Dauvermann, Maria R ; Mothersill, David ; Holland, Jessica ; Costello, Laura ; Kane, Ruán ; McKernan, Declan ; Morris, Derek W ; Kelly, John P ; Corvin, Aiden ; Hallahan, Brian ; McDonald, Colm ; Donohoe, Gary. / Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants. In: Social Cognitive and Affective Neuroscience. 2020 ; Vol. 15, No. 12. pp. 1336-1350.

Bibtex Download

@article{0f9ba662c20c42279dcf7829d3bb385b,
title = "Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants",
abstract = "Childhood trauma, and in particular physical neglect, has been repeatedly associated with lower performance on measures of social cognition (e.g. emotion recognition tasks) in both psychiatric and non-clinical populations. The neural mechanisms underpinning this association have remained unclear. Here, we investigated whether volumetric changes in three stress-sensitive regions-the amygdala, hippocampus and anterior cingulate cortex (ACC)-mediate the association between childhood trauma and emotion recognition in a healthy participant sample (N = 112) and a clinical sample of patients with schizophrenia (N = 46). Direct effects of childhood trauma, specifically physical neglect, on Emotion Recognition Task were observed in the whole sample. In healthy participants, reduced total and left ACC volumes were observed to fully mediate the association between both physical neglect and total childhood trauma score, and emotion recognition. No mediating effects of the hippocampus and amygdala volumes were observed for either group. These results suggest that reduced ACC volume may represent part of the mechanism by which early life adversity results in poorer social cognitive function. Confirmation of the causal basis of this association would highlight the importance of resilience-building interventions to mitigate the detrimental effects of childhood trauma on brain structure and function.",
author = "Rokita, {Karolina I} and Laurena Holleran and Dauvermann, {Maria R} and David Mothersill and Jessica Holland and Laura Costello and Ru{\'a}n Kane and Declan McKernan and Morris, {Derek W} and Kelly, {John P} and Aiden Corvin and Brian Hallahan and Colm McDonald and Gary Donohoe",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press.",
year = "2020",
month = dec,
day = "24",
doi = "10.1093/scan/nsaa160",
language = "English",
volume = "15",
pages = "1336--1350",
journal = "Social Cognitive and Affective Neuroscience",
issn = "1749-5016",
publisher = "OXFORD UNIV PRESS",
number = "12",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants

AU - Rokita, Karolina I

AU - Holleran, Laurena

AU - Dauvermann, Maria R

AU - Mothersill, David

AU - Holland, Jessica

AU - Costello, Laura

AU - Kane, Ruán

AU - McKernan, Declan

AU - Morris, Derek W

AU - Kelly, John P

AU - Corvin, Aiden

AU - Hallahan, Brian

AU - McDonald, Colm

AU - Donohoe, Gary

N1 - © The Author(s) 2020. Published by Oxford University Press.

PY - 2020/12/24

Y1 - 2020/12/24

N2 - Childhood trauma, and in particular physical neglect, has been repeatedly associated with lower performance on measures of social cognition (e.g. emotion recognition tasks) in both psychiatric and non-clinical populations. The neural mechanisms underpinning this association have remained unclear. Here, we investigated whether volumetric changes in three stress-sensitive regions-the amygdala, hippocampus and anterior cingulate cortex (ACC)-mediate the association between childhood trauma and emotion recognition in a healthy participant sample (N = 112) and a clinical sample of patients with schizophrenia (N = 46). Direct effects of childhood trauma, specifically physical neglect, on Emotion Recognition Task were observed in the whole sample. In healthy participants, reduced total and left ACC volumes were observed to fully mediate the association between both physical neglect and total childhood trauma score, and emotion recognition. No mediating effects of the hippocampus and amygdala volumes were observed for either group. These results suggest that reduced ACC volume may represent part of the mechanism by which early life adversity results in poorer social cognitive function. Confirmation of the causal basis of this association would highlight the importance of resilience-building interventions to mitigate the detrimental effects of childhood trauma on brain structure and function.

AB - Childhood trauma, and in particular physical neglect, has been repeatedly associated with lower performance on measures of social cognition (e.g. emotion recognition tasks) in both psychiatric and non-clinical populations. The neural mechanisms underpinning this association have remained unclear. Here, we investigated whether volumetric changes in three stress-sensitive regions-the amygdala, hippocampus and anterior cingulate cortex (ACC)-mediate the association between childhood trauma and emotion recognition in a healthy participant sample (N = 112) and a clinical sample of patients with schizophrenia (N = 46). Direct effects of childhood trauma, specifically physical neglect, on Emotion Recognition Task were observed in the whole sample. In healthy participants, reduced total and left ACC volumes were observed to fully mediate the association between both physical neglect and total childhood trauma score, and emotion recognition. No mediating effects of the hippocampus and amygdala volumes were observed for either group. These results suggest that reduced ACC volume may represent part of the mechanism by which early life adversity results in poorer social cognitive function. Confirmation of the causal basis of this association would highlight the importance of resilience-building interventions to mitigate the detrimental effects of childhood trauma on brain structure and function.

U2 - 10.1093/scan/nsaa160

DO - 10.1093/scan/nsaa160

M3 - Article

C2 - 33245126

VL - 15

SP - 1336

EP - 1350

JO - Social Cognitive and Affective Neuroscience

JF - Social Cognitive and Affective Neuroscience

SN - 1749-5016

IS - 12

ER -

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454