Chiral liquid chromatography coupled with tandem mass spectrometry for environmental analysis of pharmacologically active compounds

Bruce Petrie; Dolores Camacho-Muñoz; Erika Castrignanò; Sian Evans; Barbara Kasprzyk-Hordern

Chiral liquid chromatography coupled with tandem mass spectrometry for environmental analysis of pharmacologically active compounds

Bruce Petrie, Dolores Camacho-Muñoz, Erika Castrignanò, Sian Evans, Barbara Kasprzyk-Hordern

Analytical, Environmental & Forensic Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Determination of pharmacologically active chiral compounds (cPACs) at the enantiomeric level in environmental matrices is essential. Such an approach yields vital information for improved wastewater-based epidemiology, development of more accurate environmental risk assessment, and improved understanding of cPAC fate in wastewaters and the environment. This article gives an up-to-date commentary on chiral liquid chromatography coupled with tandem mass spectrometry (LC–MS–MS) to determine cPACs, including illicit drugs, in environmental matrices. Several applications are presented to demonstrate the benefits of performing environmental analysis of cPACs at the enantiomeric level. Finally, future perspectives in this rapidly developing field of research are outlined.

Original language	English
Journal	LC-GC Europe
Volume	28
Issue number	3
Publication status	Published - 1 Mar 2015

Cite this

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abstract = "Determination of pharmacologically active chiral compounds (cPACs) at the enantiomeric level in environmental matrices is essential. Such an approach yields vital information for improved wastewater-based epidemiology, development of more accurate environmental risk assessment, and improved understanding of cPAC fate in wastewaters and the environment. This article gives an up-to-date commentary on chiral liquid chromatography coupled with tandem mass spectrometry (LC–MS–MS) to determine cPACs, including illicit drugs, in environmental matrices. Several applications are presented to demonstrate the benefits of performing environmental analysis of cPACs at the enantiomeric level. Finally, future perspectives in this rapidly developing field of research are outlined.",

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AU - Petrie, Bruce

AU - Camacho-Muñoz, Dolores

AU - Castrignanò, Erika

AU - Evans, Sian

AU - Kasprzyk-Hordern, Barbara

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Determination of pharmacologically active chiral compounds (cPACs) at the enantiomeric level in environmental matrices is essential. Such an approach yields vital information for improved wastewater-based epidemiology, development of more accurate environmental risk assessment, and improved understanding of cPAC fate in wastewaters and the environment. This article gives an up-to-date commentary on chiral liquid chromatography coupled with tandem mass spectrometry (LC–MS–MS) to determine cPACs, including illicit drugs, in environmental matrices. Several applications are presented to demonstrate the benefits of performing environmental analysis of cPACs at the enantiomeric level. Finally, future perspectives in this rapidly developing field of research are outlined.

AB - Determination of pharmacologically active chiral compounds (cPACs) at the enantiomeric level in environmental matrices is essential. Such an approach yields vital information for improved wastewater-based epidemiology, development of more accurate environmental risk assessment, and improved understanding of cPAC fate in wastewaters and the environment. This article gives an up-to-date commentary on chiral liquid chromatography coupled with tandem mass spectrometry (LC–MS–MS) to determine cPACs, including illicit drugs, in environmental matrices. Several applications are presented to demonstrate the benefits of performing environmental analysis of cPACs at the enantiomeric level. Finally, future perspectives in this rapidly developing field of research are outlined.

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SN - 1471-6577

VL - 28

JO - LC-GC Europe

JF - LC-GC Europe

IS - 3

ER -

Chiral liquid chromatography coupled with tandem mass spectrometry for environmental analysis of pharmacologically active compounds

Abstract

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