Choosing a Mouse Model of Venous Thrombosis

Jose A. Diaz, Prakash Saha, Brian Cooley, Olivia R. Palmer, Steven P. Grover, Nigel Mackman, Thomas W. Wakefield, Peter K. Henke, Alberto Smith, Brajesh K. Lal

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Murine models are widely used valuable tools to study deep vein thrombosis. Leading experts in venous thrombosis research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of venous thrombosis. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of venous thrombosis. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.

Original languageEnglish
Pages (from-to)311-318
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume39
Issue number3
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • consensus
  • experimental animal models
  • surgical models
  • venous thromboembolism
  • venous thrombosis

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