Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application

Jose A. Diaz*, Prakash Saha, Brian Cooley, Olivia R. Palmer, Steven P. Grover, Nigel Mackman, Thomas W. Wakefield, Peter K. Henke, Alberto Smith, Brajesh K. Lal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Summary: Murine models are widely used valuable tools to study deep vein thrombosis (VT). Leading experts in VT research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of VT. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of VT. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.

Original languageEnglish
Pages (from-to)699-707
Number of pages9
JournalJournal of Thrombosis and Haemostasis
Volume17
Issue number4
Early online date30 Mar 2019
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • deep vein thrombosis
  • electrolytic inferior vena cava model
  • femoral electrolytic model
  • ferric chloride model
  • inferior vena cava (IVC)
  • mouse models
  • recurrent venous thrombosis model
  • stasis model
  • stenosis model
  • venous thromboembolism (VTE)
  • venous thrombosis

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