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CHRFAM7A copy number and 2-bp deletion polymorphisms and antisaccade performance

Research output: Contribution to journalArticle

Nadine Petrovsky, Anne Schmechtig, Rachel H Flomen, Veena Kumari, David Collier, Andrew Makoff, Michael Wagner, Ulrich Ettinger

Original languageEnglish
Pages (from-to)267 - 273
Number of pages7
JournalInternational Journal of Neuropsychopharmacology
Issue number2
Publication statusPublished - Mar 2009

King's Authors


Chromosome 15q13-q14 harbours the gene for the alpha7 nicotinic acetylcholine receptor subunit (CHRNA7) and a related gene (CHRFAM7A) which arises from a partly duplicated portion of CHRNA7. Recent evidence suggests that CHRFAM7A is a locus with a possible role in schizophrenia and cognitive functioning. We studied an antisaccade task as a fronto-parietal measure of executive function that reflects risk for schizophrenia. Association of CHRFAM7A genotype with antisaccade performance was assessed in 103 healthy Caucasian individuals. No significant associations of 2-bp deletion or CHRFAM7A copy number with antisaccade performance parameters were observed. The failure to observe an association between antisaccade performance and polymorphisms in CHRFAM7A gene is consistent with specificity of the gene effects on hippocampal and memory functions as previously demonstrated.

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