Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study

Sam Sollie; Dominique S Michaud; Debashis Sarker; Sophia N Karagiannis; Debra H Josephs; Niklas Hammar; Aida Santaolalla; Goran Walldius; Hans Garmo; Lars Holmberg; Ingmar Jungner; Mieke Van Hemelrijck

doi:10.1186/s12885-019-6082-6

Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study

Sam Sollie, Dominique S Michaud, Debashis Sarker, Sophia N Karagiannis, Debra H Josephs, Niklas Hammar, Aida Santaolalla, Goran Walldius, Hans Garmo, Lars Holmberg, Ingmar Jungner, Mieke Van Hemelrijck

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Abstract

BACKGROUND: Nested case-control studies examining the association between serum markers of chronic inflammation, focused on three specific biomarkers (CRP, IL-8 and TNF-α), and risk of pancreatic cancer have reported no associations. In this study, we evaluated associations between standard pre-diagnostic serum markers of chronic inflammation (CRP, albumin, haptoglobin and leukocytes) and pancreatic cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) prospective cohort study.

METHODS: We selected all participants (≥20 years old) with baseline measurements of CRP, albumin, haptoglobin and leukocytes between 1985 and 1996 (n = 61,597). Participants were excluded if they had a history of chronic pancreatitis and all individuals were free from pancreatic cancer at baseline. Cox proportional multivariable hazards regression analysis was carried out for medical cut-offs of CRP, albumin, haptoglobin and leukocytes.

RESULTS: We observed an increased risk of pancreatic cancer for those individuals with higher levels of serum haptoglobin (≥1.4 g/L), CRP (≥10 mg/L) and leukocytes (≥10 × 109 cells/L) compared to those with haptoglobin levels < 1.4 g/L, CRP levels < 10 mg/L and Leukocyte levels < 10 × 109 cells/L [haptoglobin HR: 2.23 (95% CI 1.72-2.88), CRP HR: 1.32 (95% CI 1.00-1.74), leukocytes HR: 2.20 (95% CI 1.52-3.18)]. No associations were noted for serum albumin.

CONCLUSIONS: We found an increased risk of pancreatic cancer associated with pre-diagnostic serum levels of haptoglobin, CRP and leukocytes. Our finding suggests a possible role of chronic inflammation in the aetiology of pancreatic cancer and highlight the need to further investigate this association.

Original language	English
Article number	858
Journal	BMC Cancer
Volume	19
Issue number	1
Early online date	29 Aug 2019
DOIs	https://doi.org/10.1186/s12885-019-6082-6
Publication status	E-pub ahead of print - 29 Aug 2019

Keywords

AMORIS
Albumin
CRP
Chronic inflammation
Haptoglobin
Leukocytes
Pancreatic cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Sollie et al BMC Cancer s12885-019-6082-6Final published version, 572 KBLicence: CC BY

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Sollie, S., Michaud, D. S., Sarker, D., Karagiannis, S. N., Josephs, D. H., Hammar, N., Santaolalla, A., Walldius, G., Garmo, H., Holmberg, L., Jungner, I., & Van Hemelrijck, M. (2019). Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study. BMC Cancer, 19(1), Article 858. Advance online publication. https://doi.org/10.1186/s12885-019-6082-6

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title = "Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study",

abstract = "BACKGROUND: Nested case-control studies examining the association between serum markers of chronic inflammation, focused on three specific biomarkers (CRP, IL-8 and TNF-α), and risk of pancreatic cancer have reported no associations. In this study, we evaluated associations between standard pre-diagnostic serum markers of chronic inflammation (CRP, albumin, haptoglobin and leukocytes) and pancreatic cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) prospective cohort study.METHODS: We selected all participants (≥20 years old) with baseline measurements of CRP, albumin, haptoglobin and leukocytes between 1985 and 1996 (n = 61,597). Participants were excluded if they had a history of chronic pancreatitis and all individuals were free from pancreatic cancer at baseline. Cox proportional multivariable hazards regression analysis was carried out for medical cut-offs of CRP, albumin, haptoglobin and leukocytes.RESULTS: We observed an increased risk of pancreatic cancer for those individuals with higher levels of serum haptoglobin (≥1.4 g/L), CRP (≥10 mg/L) and leukocytes (≥10 × 109 cells/L) compared to those with haptoglobin levels < 1.4 g/L, CRP levels < 10 mg/L and Leukocyte levels < 10 × 109 cells/L [haptoglobin HR: 2.23 (95% CI 1.72-2.88), CRP HR: 1.32 (95% CI 1.00-1.74), leukocytes HR: 2.20 (95% CI 1.52-3.18)]. No associations were noted for serum albumin.CONCLUSIONS: We found an increased risk of pancreatic cancer associated with pre-diagnostic serum levels of haptoglobin, CRP and leukocytes. Our finding suggests a possible role of chronic inflammation in the aetiology of pancreatic cancer and highlight the need to further investigate this association.",

keywords = "AMORIS, Albumin, CRP, Chronic inflammation, Haptoglobin, Leukocytes, Pancreatic cancer",

author = "Sam Sollie and Michaud, {Dominique S} and Debashis Sarker and Karagiannis, {Sophia N} and Josephs, {Debra H} and Niklas Hammar and Aida Santaolalla and Goran Walldius and Hans Garmo and Lars Holmberg and Ingmar Jungner and {Van Hemelrijck}, Mieke",

year = "2019",

month = aug,

day = "29",

doi = "10.1186/s12885-019-6082-6",

language = "English",

volume = "19",

journal = "BMC Cancer",

issn = "1471-2407",

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number = "1",

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TY - JOUR

T1 - Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study

AU - Sollie, Sam

AU - Michaud, Dominique S

AU - Sarker, Debashis

AU - Karagiannis, Sophia N

AU - Josephs, Debra H

AU - Hammar, Niklas

AU - Santaolalla, Aida

AU - Walldius, Goran

AU - Garmo, Hans

AU - Holmberg, Lars

AU - Jungner, Ingmar

AU - Van Hemelrijck, Mieke

PY - 2019/8/29

Y1 - 2019/8/29

N2 - BACKGROUND: Nested case-control studies examining the association between serum markers of chronic inflammation, focused on three specific biomarkers (CRP, IL-8 and TNF-α), and risk of pancreatic cancer have reported no associations. In this study, we evaluated associations between standard pre-diagnostic serum markers of chronic inflammation (CRP, albumin, haptoglobin and leukocytes) and pancreatic cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) prospective cohort study.METHODS: We selected all participants (≥20 years old) with baseline measurements of CRP, albumin, haptoglobin and leukocytes between 1985 and 1996 (n = 61,597). Participants were excluded if they had a history of chronic pancreatitis and all individuals were free from pancreatic cancer at baseline. Cox proportional multivariable hazards regression analysis was carried out for medical cut-offs of CRP, albumin, haptoglobin and leukocytes.RESULTS: We observed an increased risk of pancreatic cancer for those individuals with higher levels of serum haptoglobin (≥1.4 g/L), CRP (≥10 mg/L) and leukocytes (≥10 × 109 cells/L) compared to those with haptoglobin levels < 1.4 g/L, CRP levels < 10 mg/L and Leukocyte levels < 10 × 109 cells/L [haptoglobin HR: 2.23 (95% CI 1.72-2.88), CRP HR: 1.32 (95% CI 1.00-1.74), leukocytes HR: 2.20 (95% CI 1.52-3.18)]. No associations were noted for serum albumin.CONCLUSIONS: We found an increased risk of pancreatic cancer associated with pre-diagnostic serum levels of haptoglobin, CRP and leukocytes. Our finding suggests a possible role of chronic inflammation in the aetiology of pancreatic cancer and highlight the need to further investigate this association.

AB - BACKGROUND: Nested case-control studies examining the association between serum markers of chronic inflammation, focused on three specific biomarkers (CRP, IL-8 and TNF-α), and risk of pancreatic cancer have reported no associations. In this study, we evaluated associations between standard pre-diagnostic serum markers of chronic inflammation (CRP, albumin, haptoglobin and leukocytes) and pancreatic cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) prospective cohort study.METHODS: We selected all participants (≥20 years old) with baseline measurements of CRP, albumin, haptoglobin and leukocytes between 1985 and 1996 (n = 61,597). Participants were excluded if they had a history of chronic pancreatitis and all individuals were free from pancreatic cancer at baseline. Cox proportional multivariable hazards regression analysis was carried out for medical cut-offs of CRP, albumin, haptoglobin and leukocytes.RESULTS: We observed an increased risk of pancreatic cancer for those individuals with higher levels of serum haptoglobin (≥1.4 g/L), CRP (≥10 mg/L) and leukocytes (≥10 × 109 cells/L) compared to those with haptoglobin levels < 1.4 g/L, CRP levels < 10 mg/L and Leukocyte levels < 10 × 109 cells/L [haptoglobin HR: 2.23 (95% CI 1.72-2.88), CRP HR: 1.32 (95% CI 1.00-1.74), leukocytes HR: 2.20 (95% CI 1.52-3.18)]. No associations were noted for serum albumin.CONCLUSIONS: We found an increased risk of pancreatic cancer associated with pre-diagnostic serum levels of haptoglobin, CRP and leukocytes. Our finding suggests a possible role of chronic inflammation in the aetiology of pancreatic cancer and highlight the need to further investigate this association.

KW - AMORIS

KW - Albumin

KW - CRP

KW - Chronic inflammation

KW - Haptoglobin

KW - Leukocytes

KW - Pancreatic cancer

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U2 - 10.1186/s12885-019-6082-6

DO - 10.1186/s12885-019-6082-6

M3 - Article

C2 - 31464604

SN - 1471-2407

VL - 19

JO - BMC Cancer

JF - BMC Cancer

IS - 1

M1 - 858

ER -

Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study

Abstract

Keywords

UN SDGs

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