King's College London

Research portal

Chronic obstructive pulmonary disease hospital admissions and drugs-unexpected positive associations: a retrospective general practice cohort study

Research output: Contribution to journalArticle

Standard

Chronic obstructive pulmonary disease hospital admissions and drugs-unexpected positive associations : a retrospective general practice cohort study. / Harries, Timothy H; Seed, Paul T; Jones, Simon; White, Patrick; Schofield, Peter.

In: npj Primary Care Respiratory Medicine, Vol. 24, 14006, 2014.

Research output: Contribution to journalArticle

Harvard

Harries, TH, Seed, PT, Jones, S, White, P & Schofield, P 2014, 'Chronic obstructive pulmonary disease hospital admissions and drugs-unexpected positive associations: a retrospective general practice cohort study', npj Primary Care Respiratory Medicine, vol. 24, 14006. https://doi.org/10.1038/npjpcrm.2014.6

APA

Harries, T. H., Seed, P. T., Jones, S., White, P., & Schofield, P. (2014). Chronic obstructive pulmonary disease hospital admissions and drugs-unexpected positive associations: a retrospective general practice cohort study. npj Primary Care Respiratory Medicine, 24, [14006]. https://doi.org/10.1038/npjpcrm.2014.6

Vancouver

Harries TH, Seed PT, Jones S, White P, Schofield P. Chronic obstructive pulmonary disease hospital admissions and drugs-unexpected positive associations: a retrospective general practice cohort study. npj Primary Care Respiratory Medicine. 2014;24. 14006. https://doi.org/10.1038/npjpcrm.2014.6

Author

Harries, Timothy H ; Seed, Paul T ; Jones, Simon ; White, Patrick ; Schofield, Peter. / Chronic obstructive pulmonary disease hospital admissions and drugs-unexpected positive associations : a retrospective general practice cohort study. In: npj Primary Care Respiratory Medicine. 2014 ; Vol. 24.

Bibtex Download

@article{d4c351afbf8241ae91c4f68499ba42e9,
title = "Chronic obstructive pulmonary disease hospital admissions and drugs-unexpected positive associations: a retrospective general practice cohort study",
abstract = "Background: Increased prescribing of inhaled long-acting anti-muscarinic (LAMA) and combined inhaled long-acting β2-agonist and corticosteroid (LABA+ICS) drugs for the treatment of chronic obstructive pulmonary disease (COPD) has led to hopes of reduced hospital admissions from this disease.Aims: To investigate the impact of rising primary care prescribing of LAMA and LABA+ICS drugs on COPD admissions.Methods: This retrospective cohort study of general practice COPD admission and prescribing data between 2007 and 2010 comprised a representative group of 806 English general practices (population 5,264,506). Outcome measures were practice rates of COPD patient admissions and prescription costs of LAMA and LABA+ICS. General practice characteristics were based on the UK quality and outcomes framework.Results: Rates of COPD admissions remained stable from 2001 to 2010. Practice-prescribing volumes of LAMA per practice patient and LABA+ICS per practice patient increased by 61 and 26{\%}, respectively, between 2007 and 2010. Correlation between costs of LAMA and those of LABA+ICS increased year on year, and was the highest in 2010 (Pearson's r=0.68; 95{\%} confidence interval (CI) 0.64 to 0.72). Practice COPD admission rates were positively predicted by practice-prescribing volumes of LAMA (2010: B=1.23, 95{\%} CI 0.61 to 1.85) and of LABA+ICS (2010: B=0.32, 95{\%} CI 0.12 to 0.52) when controlling for practice list size, COPD prevalence and deprivation.Conclusion: The increase in the prescribing of LAMA and LABA+ICS inhalers was not associated with the predicted fall in hospital admission rates for COPD patients. The positive correlation between high practice COPD prescribing and high practice COPD admissions was not explained.",
author = "Harries, {Timothy H} and Seed, {Paul T} and Simon Jones and Patrick White and Peter Schofield",
year = "2014",
doi = "10.1038/npjpcrm.2014.6",
language = "English",
volume = "24",
journal = "npj Primary Care Respiratory Medicine",
issn = "2055-1010",
publisher = "Nature Publishing Group",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Chronic obstructive pulmonary disease hospital admissions and drugs-unexpected positive associations

T2 - a retrospective general practice cohort study

AU - Harries, Timothy H

AU - Seed, Paul T

AU - Jones, Simon

AU - White, Patrick

AU - Schofield, Peter

PY - 2014

Y1 - 2014

N2 - Background: Increased prescribing of inhaled long-acting anti-muscarinic (LAMA) and combined inhaled long-acting β2-agonist and corticosteroid (LABA+ICS) drugs for the treatment of chronic obstructive pulmonary disease (COPD) has led to hopes of reduced hospital admissions from this disease.Aims: To investigate the impact of rising primary care prescribing of LAMA and LABA+ICS drugs on COPD admissions.Methods: This retrospective cohort study of general practice COPD admission and prescribing data between 2007 and 2010 comprised a representative group of 806 English general practices (population 5,264,506). Outcome measures were practice rates of COPD patient admissions and prescription costs of LAMA and LABA+ICS. General practice characteristics were based on the UK quality and outcomes framework.Results: Rates of COPD admissions remained stable from 2001 to 2010. Practice-prescribing volumes of LAMA per practice patient and LABA+ICS per practice patient increased by 61 and 26%, respectively, between 2007 and 2010. Correlation between costs of LAMA and those of LABA+ICS increased year on year, and was the highest in 2010 (Pearson's r=0.68; 95% confidence interval (CI) 0.64 to 0.72). Practice COPD admission rates were positively predicted by practice-prescribing volumes of LAMA (2010: B=1.23, 95% CI 0.61 to 1.85) and of LABA+ICS (2010: B=0.32, 95% CI 0.12 to 0.52) when controlling for practice list size, COPD prevalence and deprivation.Conclusion: The increase in the prescribing of LAMA and LABA+ICS inhalers was not associated with the predicted fall in hospital admission rates for COPD patients. The positive correlation between high practice COPD prescribing and high practice COPD admissions was not explained.

AB - Background: Increased prescribing of inhaled long-acting anti-muscarinic (LAMA) and combined inhaled long-acting β2-agonist and corticosteroid (LABA+ICS) drugs for the treatment of chronic obstructive pulmonary disease (COPD) has led to hopes of reduced hospital admissions from this disease.Aims: To investigate the impact of rising primary care prescribing of LAMA and LABA+ICS drugs on COPD admissions.Methods: This retrospective cohort study of general practice COPD admission and prescribing data between 2007 and 2010 comprised a representative group of 806 English general practices (population 5,264,506). Outcome measures were practice rates of COPD patient admissions and prescription costs of LAMA and LABA+ICS. General practice characteristics were based on the UK quality and outcomes framework.Results: Rates of COPD admissions remained stable from 2001 to 2010. Practice-prescribing volumes of LAMA per practice patient and LABA+ICS per practice patient increased by 61 and 26%, respectively, between 2007 and 2010. Correlation between costs of LAMA and those of LABA+ICS increased year on year, and was the highest in 2010 (Pearson's r=0.68; 95% confidence interval (CI) 0.64 to 0.72). Practice COPD admission rates were positively predicted by practice-prescribing volumes of LAMA (2010: B=1.23, 95% CI 0.61 to 1.85) and of LABA+ICS (2010: B=0.32, 95% CI 0.12 to 0.52) when controlling for practice list size, COPD prevalence and deprivation.Conclusion: The increase in the prescribing of LAMA and LABA+ICS inhalers was not associated with the predicted fall in hospital admission rates for COPD patients. The positive correlation between high practice COPD prescribing and high practice COPD admissions was not explained.

U2 - 10.1038/npjpcrm.2014.6

DO - 10.1038/npjpcrm.2014.6

M3 - Article

C2 - 24842126

VL - 24

JO - npj Primary Care Respiratory Medicine

JF - npj Primary Care Respiratory Medicine

SN - 2055-1010

M1 - 14006

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454