Chronic Pain: Emerging Evidence for the Involvement of Epigenetics

Franziska Denk; Stephen B McMahon

doi:10.1016/j.neuron.2012.01.012

Chronic Pain: Emerging Evidence for the Involvement of Epigenetics

Franziska Denk, Stephen B McMahon

Research output: Contribution to journal › Article › peer-review

210 Citations (Scopus)

Abstract

Epigenetic processes, such as histone modifications and DNA methylation, have been associated with many neural functions including synaptic plasticity, learning, and memory. Here, we critically examine emerging evidence linking epigenetic mechanisms to the development or maintenance of chronic pain states. Although in its infancy, research in this area potentially unifies several pathophysiological processes underpinning abnormal pain processing and opens up a different avenue for the development of novel analgesics.

Original language	English
Pages (from-to)	435-44
Number of pages	10
Journal	Neuron
Volume	73
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2012.01.012
Publication status	Published - 9 Feb 2012

Keywords

Afferent Pathways
Chronic Pain
Epigenesis, Genetic
Epigenomics
Humans
Models, Biological

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Chronic Pain: Emerging Evidence for the Involvement of Epigenetics

Abstract

Keywords

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