Cilia-mediated hedgehog signaling controls form and function in the mammalian larynx

Jacqueline M. Tabler; Maggie M. Rigney; Gordon J. Berman; Swetha Gopalakrishnan; Eglantine Heude; Hadeel Adel Al-Lami; Basil Z. Yannakoudiadkis; Rebecca D. Fitch; Christopher Carter; Steven Vokes; Karen J. Liu; Shahragim Tajbakhsh; S. E Roian Egnor; John B. Wallingford

doi:10.7554/eLife.19153

Cilia-mediated hedgehog signaling controls form and function in the mammalian larynx

Jacqueline M. Tabler, Maggie M. Rigney, Gordon J. Berman, Swetha Gopalakrishnan, Eglantine Heude, Hadeel Adel Al-Lami, Basil Z. Yannakoudiadkis, Rebecca D. Fitch, Christopher Carter, Steven Vokes, Karen J. Liu, Shahragim Tajbakhsh, S. E Roian Egnor, John B. Wallingford^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Acoustic communication is fundamental to social interactions among animals, including humans. In fact, deficits in voice impair the quality of life for a large and diverse population of patients. Understanding the molecular genetic mechanisms of development and function in the vocal apparatus is thus an important challenge with relevance both to the basic biology of animal communication and to biomedicine. However, surprisingly little is known about the developmental biology of the mammalian larynx. Here, we used genetic fate mapping to chart the embryological origins of the tissues in the mouse larynx, and we describe the developmental etiology of laryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling. In addition, we show that mild laryngeal defects correlate with changes in the acoustic structure of vocalizations. Together, these data provide key new insights into the molecular genetics of form and function in the mammalian vocal apparatus.

Original language	English
Article number	e19153
Number of pages	26
Journal	eLife
Volume	6
DOIs	https://doi.org/10.7554/eLife.19153
Publication status	Published - 13 Feb 2017

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Cilia-mediated Hedgehog signaling_TABLER_Published13February2017_GOLD VoR (CC-BY)Final published version, 12.1 MBLicence: CC BY

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Tabler, J. M., Rigney, M. M., Berman, G. J., Gopalakrishnan, S., Heude, E., Al-Lami, H. A., Yannakoudiadkis, B. Z., Fitch, R. D., Carter, C., Vokes, S., Liu, K. J., Tajbakhsh, S., Egnor, S. E. R., & Wallingford, J. B. (2017). Cilia-mediated hedgehog signaling controls form and function in the mammalian larynx. eLife, 6, Article e19153. https://doi.org/10.7554/eLife.19153

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title = "Cilia-mediated hedgehog signaling controls form and function in the mammalian larynx",

abstract = "Acoustic communication is fundamental to social interactions among animals, including humans. In fact, deficits in voice impair the quality of life for a large and diverse population of patients. Understanding the molecular genetic mechanisms of development and function in the vocal apparatus is thus an important challenge with relevance both to the basic biology of animal communication and to biomedicine. However, surprisingly little is known about the developmental biology of the mammalian larynx. Here, we used genetic fate mapping to chart the embryological origins of the tissues in the mouse larynx, and we describe the developmental etiology of laryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling. In addition, we show that mild laryngeal defects correlate with changes in the acoustic structure of vocalizations. Together, these data provide key new insights into the molecular genetics of form and function in the mammalian vocal apparatus.",

author = "Tabler, {Jacqueline M.} and Rigney, {Maggie M.} and Berman, {Gordon J.} and Swetha Gopalakrishnan and Eglantine Heude and Al-Lami, {Hadeel Adel} and Yannakoudiadkis, {Basil Z.} and Fitch, {Rebecca D.} and Christopher Carter and Steven Vokes and Liu, {Karen J.} and Shahragim Tajbakhsh and Egnor, {S. E Roian} and Wallingford, {John B.}",

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AU - Tabler, Jacqueline M.

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AU - Berman, Gordon J.

AU - Gopalakrishnan, Swetha

AU - Heude, Eglantine

AU - Al-Lami, Hadeel Adel

AU - Yannakoudiadkis, Basil Z.

AU - Fitch, Rebecca D.

AU - Carter, Christopher

AU - Vokes, Steven

AU - Liu, Karen J.

AU - Tajbakhsh, Shahragim

AU - Egnor, S. E Roian

AU - Wallingford, John B.

PY - 2017/2/13

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N2 - Acoustic communication is fundamental to social interactions among animals, including humans. In fact, deficits in voice impair the quality of life for a large and diverse population of patients. Understanding the molecular genetic mechanisms of development and function in the vocal apparatus is thus an important challenge with relevance both to the basic biology of animal communication and to biomedicine. However, surprisingly little is known about the developmental biology of the mammalian larynx. Here, we used genetic fate mapping to chart the embryological origins of the tissues in the mouse larynx, and we describe the developmental etiology of laryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling. In addition, we show that mild laryngeal defects correlate with changes in the acoustic structure of vocalizations. Together, these data provide key new insights into the molecular genetics of form and function in the mammalian vocal apparatus.

AB - Acoustic communication is fundamental to social interactions among animals, including humans. In fact, deficits in voice impair the quality of life for a large and diverse population of patients. Understanding the molecular genetic mechanisms of development and function in the vocal apparatus is thus an important challenge with relevance both to the basic biology of animal communication and to biomedicine. However, surprisingly little is known about the developmental biology of the mammalian larynx. Here, we used genetic fate mapping to chart the embryological origins of the tissues in the mouse larynx, and we describe the developmental etiology of laryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling. In addition, we show that mild laryngeal defects correlate with changes in the acoustic structure of vocalizations. Together, these data provide key new insights into the molecular genetics of form and function in the mammalian vocal apparatus.

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SN - 2050-084X

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JO - eLife

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ER -

Cilia-mediated hedgehog signaling controls form and function in the mammalian larynx

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