Cingulate-precuneus interactions: A new locus of dysfunction in adult attention-deficit/hyperactivity disorder

F X Castellanos; D S Margulies; C Kelly; L Q Uddin; M Ghaffari; A Kirsch; D Shaw; Z Shehzad; A Di Martino; B Biswal; E J S Sonuga-Barke; J Rotrosen; L A Adler; M P Milham

doi:10.1016/j.biopsych.2007.06.025

Cingulate-precuneus interactions: A new locus of dysfunction in adult attention-deficit/hyperactivity disorder

F X Castellanos, D S Margulies, C Kelly, L Q Uddin, M Ghaffari, A Kirsch, D Shaw, Z Shehzad, A Di Martino, B Biswal, E J S Sonuga-Barke, J Rotrosen, L A Adler, M P Milham

Centre for Host Microbiome Interactions

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Abstract

Background: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. Methods: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age-and sex-matched healthy volunteers. Results: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered atx = 8, y = 7,z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p

Original language	English
Pages (from-to)	332 - 337
Number of pages	6
Journal	Biological psychiatry
Volume	63
Issue number	3
DOIs	https://doi.org/10.1016/j.biopsych.2007.06.025
Publication status	Published - 1 Feb 2008

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Castellanos, F. X., Margulies, D. S., Kelly, C., Uddin, L. Q., Ghaffari, M., Kirsch, A., Shaw, D., Shehzad, Z., Di Martino, A., Biswal, B., Sonuga-Barke, E. J. S., Rotrosen, J., Adler, L. A., & Milham, M. P. (2008). Cingulate-precuneus interactions: A new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biological psychiatry, 63(3), 332 - 337. https://doi.org/10.1016/j.biopsych.2007.06.025

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title = "Cingulate-precuneus interactions: A new locus of dysfunction in adult attention-deficit/hyperactivity disorder",

abstract = "Background: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed {"}default-mode{"} network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. Methods: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age-and sex-matched healthy volunteers. Results: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered atx = 8, y = 7,z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p ",

author = "Castellanos, {F X} and Margulies, {D S} and C Kelly and Uddin, {L Q} and M Ghaffari and A Kirsch and D Shaw and Z Shehzad and {Di Martino}, A and B Biswal and Sonuga-Barke, {E J S} and J Rotrosen and Adler, {L A} and Milham, {M P}",

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Castellanos, FX, Margulies, DS, Kelly, C, Uddin, LQ, Ghaffari, M, Kirsch, A, Shaw, D, Shehzad, Z, Di Martino, A, Biswal, B, Sonuga-Barke, EJS, Rotrosen, J, Adler, LA & Milham, MP 2008, 'Cingulate-precuneus interactions: A new locus of dysfunction in adult attention-deficit/hyperactivity disorder', Biological psychiatry, vol. 63, no. 3, pp. 332 - 337. https://doi.org/10.1016/j.biopsych.2007.06.025

TY - JOUR

T1 - Cingulate-precuneus interactions: A new locus of dysfunction in adult attention-deficit/hyperactivity disorder

AU - Castellanos, F X

AU - Margulies, D S

AU - Kelly, C

AU - Uddin, L Q

AU - Ghaffari, M

AU - Kirsch, A

AU - Shaw, D

AU - Shehzad, Z

AU - Di Martino, A

AU - Biswal, B

AU - Sonuga-Barke, E J S

AU - Rotrosen, J

AU - Adler, L A

AU - Milham, M P

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Background: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. Methods: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age-and sex-matched healthy volunteers. Results: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered atx = 8, y = 7,z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p

AB - Background: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. Methods: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age-and sex-matched healthy volunteers. Results: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered atx = 8, y = 7,z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p

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DO - 10.1016/j.biopsych.2007.06.025

M3 - Article

SN - 1873-2402

VL - 63

SP - 332

EP - 337

JO - Biological psychiatry

JF - Biological psychiatry

IS - 3

ER -

Cingulate-precuneus interactions: A new locus of dysfunction in adult attention-deficit/hyperactivity disorder

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