Circadian changes in long noncoding RNAs in the pineal gland

Steven L. Coon; Peter J. Munson; Praveen F. Cherukuri; David Sugden; Martin F. Rath; Morten Moller; Samuel J. H. Clokie; Cong Fu; Mary E. Olanich; Zoila Rangel; Thomas Werner; James C. Mullikin; David C. Klein; NISC Comparative Sequencing Progra

doi:10.1073/pnas.1207748109

Circadian changes in long noncoding RNAs in the pineal gland

Steven L. Coon, Peter J. Munson, Praveen F. Cherukuri, David Sugden, Martin F. Rath, Morten Moller, Samuel J. H. Clokie, Cong Fu, Mary E. Olanich, Zoila Rangel, Thomas Werner, James C. Mullikin, David C. Klein, NISC Comparative Sequencing Progra

Women & Children's Health

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.

Original language	English
Pages (from-to)	13319-13324
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	109
Issue number	33
Early online date	3 Aug 2012
DOIs	https://doi.org/10.1073/pnas.1207748109
Publication status	Published - 14 Aug 2012

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Coon, S. L., Munson, P. J., Cherukuri, P. F., Sugden, D., Rath, M. F., Moller, M., Clokie, S. J. H., Fu, C., Olanich, M. E., Rangel, Z., Werner, T., Mullikin, J. C., Klein, D. C., & NISC Comparative Sequencing Progra (2012). Circadian changes in long noncoding RNAs in the pineal gland. Proceedings of the National Academy of Sciences of the United States of America, 109(33), 13319-13324. https://doi.org/10.1073/pnas.1207748109

@article{3f1382d1f98f4974b7f8d00b3a04f936,

title = "Circadian changes in long noncoding RNAs in the pineal gland",

abstract = "Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.",

author = "Coon, {Steven L.} and Munson, {Peter J.} and Cherukuri, {Praveen F.} and David Sugden and Rath, {Martin F.} and Morten Moller and Clokie, {Samuel J. H.} and Cong Fu and Olanich, {Mary E.} and Zoila Rangel and Thomas Werner and Mullikin, {James C.} and Klein, {David C.} and {NISC Comparative Sequencing Progra}",

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doi = "10.1073/pnas.1207748109",

language = "English",

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Coon, SL, Munson, PJ, Cherukuri, PF, Sugden, D, Rath, MF, Moller, M, Clokie, SJH, Fu, C, Olanich, ME, Rangel, Z, Werner, T, Mullikin, JC, Klein, DC & NISC Comparative Sequencing Progra 2012, 'Circadian changes in long noncoding RNAs in the pineal gland', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 33, pp. 13319-13324. https://doi.org/10.1073/pnas.1207748109

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T1 - Circadian changes in long noncoding RNAs in the pineal gland

AU - Coon, Steven L.

AU - Munson, Peter J.

AU - Cherukuri, Praveen F.

AU - Sugden, David

AU - Rath, Martin F.

AU - Moller, Morten

AU - Clokie, Samuel J. H.

AU - Fu, Cong

AU - Olanich, Mary E.

AU - Rangel, Zoila

AU - Werner, Thomas

AU - Mullikin, James C.

AU - Klein, David C.

AU - NISC Comparative Sequencing Progra

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N2 - Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.

AB - Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.

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DO - 10.1073/pnas.1207748109

M3 - Article

SN - 0027-8424

VL - 109

SP - 13319

EP - 13324

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 33

ER -

Circadian changes in long noncoding RNAs in the pineal gland

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