Circadian changes of type II adenylyl cyclase mRNA in the rat suprachiasmatic nuclei

F R Cagampang, F A Antoni, S M Smith, H D Piggins, C W Coen

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10 Citations (Scopus)


Circadian functions of the suprachiasmatic nuclei (SCN) are influenced by cyclic AMP (cAMP). Adenylyl cyclase type II (AC-II) is a cAMP-generating enzyme which, in the context of activation by Gsalpha, is further stimulated by protein kinase C or G protein betagamma subunits. Using in situ hybridization we have found a biphasic variation in AC-II mRNA within the rat SCN during the light-dark cycle (peaks at Zeitgeber time 6 and 18) and also in constant darkness (peaks at circadian time 2 and 14). The cingulate cortex showed no such variation. These findings suggest that circadian changes in AC-II expression may be pertinent to the rhythmic functions of the SCN.
Original languageEnglish
Pages (from-to)279-82
Number of pages4
JournalBrain Research Bulletin
Issue number1-2
Publication statusPublished - 9 Nov 1998


  • Adenylate Cyclase
  • Animals
  • Autoradiography
  • Circadian Rhythm
  • DNA, Complementary
  • Histocytochemistry
  • In Situ Hybridization
  • Male
  • RNA, Messenger
  • Rats
  • Rats, Wistar
  • Suprachiasmatic Nucleus


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