TY - JOUR
T1 - Circadian rhythms in ischaemic heart disease
T2 - key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart
AU - Lecour, Sandrine
AU - Du Pré, Bastiaan C.
AU - Bøtker, Hans Erik
AU - Brundel, Bianca J.J.M.
AU - Daiber, Andreas
AU - Davidson, Sean M.
AU - Ferdinandy, Peter
AU - Girao, Henrique
AU - Gollmann-Tepeköylü, Can
AU - Gyöngyösi, Mariann
AU - Hausenloy, Derek J.
AU - Madonna, Rosalinda
AU - Marber, Michael
AU - Perrino, Cinzia
AU - Pesce, Maurizio
AU - Schulz, Rainer
AU - Sluijter, Joost P.G.
AU - Steffens, Sabine
AU - Van Linthout, Sophie
AU - Young, Martin E.
AU - Van Laake, Linda W.
N1 - Publisher Copyright:
© 2021 Published on behalf of the European Society of Cardiology. All rights reserved.
PY - 2022/9/10
Y1 - 2022/9/10
N2 - Circadian rhythms are internal regulatory processes controlled by molecular clocks present in essentially every mammalian organ that temporally regulate major physiological functions. In the cardiovascular system, the circadian clock governs heart rate, blood pressure, cardiac metabolism, contractility, and coagulation. Recent experimental and clinical studies highlight the possible importance of circadian rhythms in the pathophysiology, outcome, or treatment success of cardiovascular disease, including ischaemic heart disease. Disturbances in circadian rhythms are associated with increased cardiovascular risk and worsen outcome. Therefore, it is important to consider circadian rhythms as a key research parameter to better understand cardiac physiology/pathology, and to improve the chances of translation and efficacy of cardiac therapies, including those for ischaemic heart disease. The aim of this Position Paper by the European Society of Cardiology Working Group Cellular Biology of the Heart is to highlight key aspects of circadian rhythms to consider for improvement of preclinical and translational studies related to ischaemic heart disease and cardioprotection. Applying these considerations to future studies may increase the potential for better translation of new treatments into successful clinical outcomes.
AB - Circadian rhythms are internal regulatory processes controlled by molecular clocks present in essentially every mammalian organ that temporally regulate major physiological functions. In the cardiovascular system, the circadian clock governs heart rate, blood pressure, cardiac metabolism, contractility, and coagulation. Recent experimental and clinical studies highlight the possible importance of circadian rhythms in the pathophysiology, outcome, or treatment success of cardiovascular disease, including ischaemic heart disease. Disturbances in circadian rhythms are associated with increased cardiovascular risk and worsen outcome. Therefore, it is important to consider circadian rhythms as a key research parameter to better understand cardiac physiology/pathology, and to improve the chances of translation and efficacy of cardiac therapies, including those for ischaemic heart disease. The aim of this Position Paper by the European Society of Cardiology Working Group Cellular Biology of the Heart is to highlight key aspects of circadian rhythms to consider for improvement of preclinical and translational studies related to ischaemic heart disease and cardioprotection. Applying these considerations to future studies may increase the potential for better translation of new treatments into successful clinical outcomes.
KW - Cardioprotection
KW - Circadian rhythm
KW - Ischaemic heart disease
KW - Translational research
UR - http://www.scopus.com/inward/record.url?scp=85125961305&partnerID=8YFLogxK
U2 - 10.1093/cvr/cvab293
DO - 10.1093/cvr/cvab293
M3 - Article
C2 - 34505881
AN - SCOPUS:85125961305
SN - 0008-6363
VL - 118
SP - 2566
EP - 2581
JO - Cardiovascular Research
JF - Cardiovascular Research
IS - 12
ER -
