Circulating glucuronic acid predicts healthspan and longevity in humans and mice

Andrew Ho; Jonah Sinick; Tõnu Esko; Krista Fischer; Cristina Menni; Jonas Zierer; Maria Matey-Hernandez; Kristen Fortney; Eric K. Morgen

doi:10.18632/aging.102281

Circulating glucuronic acid predicts healthspan and longevity in humans and mice

Andrew Ho, Jonah Sinick, Tõnu Esko, Krista Fischer, Cristina Menni, Jonas Zierer, Maria Matey-Hernandez, Kristen Fortney^*, Eric K. Morgen

^*Corresponding author for this work

Twin Research & Genetic Epidemiology

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We find that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries with 4-20 years of follow-up (HR=1.44, p=2.9×10^-6 in the discovery cohort; HR=1.13, p=0.032 and HR=1.25, p=0.017, respectively in the replication cohorts), as well as in a longitudinal study of genetically heterogenous mice (HR=1.29, p=0.018). Additionally, we find that glucuronic acid levels increase with age and predict future healthspan-related outcomes. Together, these results demonstrate glucuronic acid as a robust biomarker of longevity and healthspan.

Original language	English
Pages (from-to)	7694-7706
Number of pages	13
Journal	Aging
Volume	11
Issue number	18
DOIs	https://doi.org/10.18632/aging.102281
Publication status	Published - 1 Jan 2019

Keywords

Aging
Glucuronate
Glucuronic acid
Lifespan
Mortality

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title = "Circulating glucuronic acid predicts healthspan and longevity in humans and mice",

abstract = "Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We find that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries with 4-20 years of follow-up (HR=1.44, p=2.9×10-6 in the discovery cohort; HR=1.13, p=0.032 and HR=1.25, p=0.017, respectively in the replication cohorts), as well as in a longitudinal study of genetically heterogenous mice (HR=1.29, p=0.018). Additionally, we find that glucuronic acid levels increase with age and predict future healthspan-related outcomes. Together, these results demonstrate glucuronic acid as a robust biomarker of longevity and healthspan.",

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AU - Ho, Andrew

AU - Sinick, Jonah

AU - Esko, Tõnu

AU - Fischer, Krista

AU - Menni, Cristina

AU - Zierer, Jonas

AU - Matey-Hernandez, Maria

AU - Fortney, Kristen

AU - Morgen, Eric K.

PY - 2019/1/1

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N2 - Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We find that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries with 4-20 years of follow-up (HR=1.44, p=2.9×10-6 in the discovery cohort; HR=1.13, p=0.032 and HR=1.25, p=0.017, respectively in the replication cohorts), as well as in a longitudinal study of genetically heterogenous mice (HR=1.29, p=0.018). Additionally, we find that glucuronic acid levels increase with age and predict future healthspan-related outcomes. Together, these results demonstrate glucuronic acid as a robust biomarker of longevity and healthspan.

AB - Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We find that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries with 4-20 years of follow-up (HR=1.44, p=2.9×10-6 in the discovery cohort; HR=1.13, p=0.032 and HR=1.25, p=0.017, respectively in the replication cohorts), as well as in a longitudinal study of genetically heterogenous mice (HR=1.29, p=0.018). Additionally, we find that glucuronic acid levels increase with age and predict future healthspan-related outcomes. Together, these results demonstrate glucuronic acid as a robust biomarker of longevity and healthspan.

KW - Aging

KW - Glucuronate

KW - Glucuronic acid

KW - Lifespan

KW - Mortality

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Circulating glucuronic acid predicts healthspan and longevity in humans and mice

Abstract

Keywords

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