Circulating glucuronic acid predicts healthspan and longevity in humans and mice

Andrew Ho, Jonah Sinick, Tõnu Esko, Krista Fischer, Cristina Menni, Jonas Zierer, Maria Matey-Hernandez, Kristen Fortney*, Eric K. Morgen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We find that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries with 4-20 years of follow-up (HR=1.44, p=2.9×10-6 in the discovery cohort; HR=1.13, p=0.032 and HR=1.25, p=0.017, respectively in the replication cohorts), as well as in a longitudinal study of genetically heterogenous mice (HR=1.29, p=0.018). Additionally, we find that glucuronic acid levels increase with age and predict future healthspan-related outcomes. Together, these results demonstrate glucuronic acid as a robust biomarker of longevity and healthspan.

Original languageEnglish
Pages (from-to)7694-7706
Number of pages13
JournalAging
Volume11
Issue number18
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Aging
  • Glucuronate
  • Glucuronic acid
  • Lifespan
  • Mortality

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