Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy

Mark Anderson; Jeffery Gersch; Ka Cheung Luk; George Dawson; Ivana Carey; Kosh Agarwal; Pir Shah; Geoffrey Dusheiko; Daryl Lau; Gavin Cloherty

doi:10.1093/cid/ciaa1015

Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy

Mark Anderson, Jeffery Gersch, Ka Cheung Luk, George Dawson, Ivana Carey, Kosh Agarwal, Pir Shah, Geoffrey Dusheiko, Daryl Lau, Gavin Cloherty

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. These results clarify the major identity of circulating HBV RNA species.

Original language	English
Pages (from-to)	2029-2031
Number of pages	3
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	72
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciaa1015
Publication status	Published - 1 Jun 2021

Keywords

hepatitis B virus
pregenomic RNA
quantitative polymerase chain reaction
viral diagnostic assay

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/cid/ciaa1015

Cite this

Anderson, M., Gersch, J., Luk, K. C., Dawson, G., Carey, I., Agarwal, K., Shah, P., Dusheiko, G., Lau, D., & Cloherty, G. (2021). Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 72(11), 2029-2031. https://doi.org/10.1093/cid/ciaa1015

@article{9ad2b599d6c946409bb8a9a00cab5dc3,

title = "Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy",

abstract = "Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. These results clarify the major identity of circulating HBV RNA species.",

keywords = "hepatitis B virus, pregenomic RNA, quantitative polymerase chain reaction, viral diagnostic assay",

author = "Mark Anderson and Jeffery Gersch and Luk, {Ka Cheung} and George Dawson and Ivana Carey and Kosh Agarwal and Pir Shah and Geoffrey Dusheiko and Daryl Lau and Gavin Cloherty",

note = "Funding Information: This work was supported by Abbott Diagnostics Division Research and Development funding. Publisher Copyright: {\textcopyright} 2020 The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jun,

day = "1",

doi = "10.1093/cid/ciaa1015",

language = "English",

volume = "72",

pages = "2029--2031",

journal = "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",

issn = "1058-4838",

publisher = "Oxford University Press (OUP)",

number = "11",

}

Anderson, M, Gersch, J, Luk, KC, Dawson, G, Carey, I , Agarwal, K, Shah, P, Dusheiko, G, Lau, D & Cloherty, G 2021, 'Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 72, no. 11, pp. 2029-2031. https://doi.org/10.1093/cid/ciaa1015

Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy. / Anderson, Mark; Gersch, Jeffery; Luk, Ka Cheung et al.
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 72, No. 11, 01.06.2021, p. 2029-2031.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy

AU - Anderson, Mark

AU - Gersch, Jeffery

AU - Luk, Ka Cheung

AU - Dawson, George

AU - Carey, Ivana

AU - Agarwal, Kosh

AU - Shah, Pir

AU - Dusheiko, Geoffrey

AU - Lau, Daryl

AU - Cloherty, Gavin

N1 - Funding Information: This work was supported by Abbott Diagnostics Division Research and Development funding. Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. These results clarify the major identity of circulating HBV RNA species.

AB - Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. These results clarify the major identity of circulating HBV RNA species.

KW - hepatitis B virus

KW - pregenomic RNA

KW - quantitative polymerase chain reaction

KW - viral diagnostic assay

UR - http://www.scopus.com/inward/record.url?scp=85106413537&partnerID=8YFLogxK

U2 - 10.1093/cid/ciaa1015

DO - 10.1093/cid/ciaa1015

M3 - Article

C2 - 32687164

AN - SCOPUS:85106413537

SN - 1058-4838

VL - 72

SP - 2029

EP - 2031

JO - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

IS - 11

ER -

Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this