Classification and biology of tumour associated stromal cells

Lizzia Raffaghello*, Francesco Dazzi

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)


    Stroma is a fundamental component of the tumour microenvironment whereby it supports malignant cell growth and spreading. It consists of different entities including cells of the immune system, vascular structures and fibroblasts. Much attention has recently been paid to fibroblasts since there is compelling evidence that they orchestrate the recruitment of and educate other cells to promote cancer growth. This review proposes to discuss in detail the nomenclature, origin, and biological functions of the different stromal cells residing in tumours.

    Original languageEnglish
    Pages (from-to)175-182
    Number of pages8
    JournalImmunology Letters
    Issue number2
    Early online date2 Jul 2015
    Publication statusPublished - 1 Dec 2015


    • Cancer associated fibroblasts
    • Fibrocytes
    • Mesenchymal stem cells
    • Tumor stroma


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