Classification and biology of tumour associated stromal cells

TY - JOUR

T1 - Classification and biology of tumour associated stromal cells

AU - Raffaghello, Lizzia

AU - Dazzi, Francesco

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Stroma is a fundamental component of the tumour microenvironment whereby it supports malignant cell growth and spreading. It consists of different entities including cells of the immune system, vascular structures and fibroblasts. Much attention has recently been paid to fibroblasts since there is compelling evidence that they orchestrate the recruitment of and educate other cells to promote cancer growth. This review proposes to discuss in detail the nomenclature, origin, and biological functions of the different stromal cells residing in tumours.

AB - Stroma is a fundamental component of the tumour microenvironment whereby it supports malignant cell growth and spreading. It consists of different entities including cells of the immune system, vascular structures and fibroblasts. Much attention has recently been paid to fibroblasts since there is compelling evidence that they orchestrate the recruitment of and educate other cells to promote cancer growth. This review proposes to discuss in detail the nomenclature, origin, and biological functions of the different stromal cells residing in tumours.

KW - Cancer associated fibroblasts

KW - Fibrocytes

KW - Mesenchymal stem cells

KW - Tumor stroma

UR - http://www.scopus.com/inward/record.url?scp=84949624886&partnerID=8YFLogxK

U2 - 10.1016/j.imlet.2015.06.016

DO - 10.1016/j.imlet.2015.06.016

M3 - Article

AN - SCOPUS:84949624886

SN - 0165-2478

VL - 168

SP - 175

EP - 182

JO - Immunology Letters

JF - Immunology Letters

IS - 2

ER -