Clinical and functional outcomes at 7-year follow-up of children presenting putative antecedents of schizophrenia at age 9-12 years

Alexis Cullen; Ruth E. Roberts; Helen Fisher; Kristin R. Laurens

doi:10.1038/s41537-024-00507-8

Clinical and functional outcomes at 7-year follow-up of children presenting putative antecedents of schizophrenia at age 9-12 years

Alexis Cullen, Ruth E. Roberts, Helen Fisher, Kristin R. Laurens

University College London, UK; Anna Freud National Centre for Children and Families; The Kantor Centre of Excellence, London, UK.

Research output: Contribution to journal › Article › peer-review

19 Downloads (Pure)

Abstract

Identification of youth presenting early risk factors for psychosis may facilitate preventive intervention. Through school-based screening, we recruited 112 children aged 9-12 years who presented multiple putative antecedents of schizophrenia (ASz), a family history of schizophrenia (FHx), or neither of these risk factors (typically-developing; TD). Clinical and functional outcomes were assessed at age 17-21 years (N=93). Compared to the TD group, the ASz group had higher total Prodromal Questionnaire (PQ) scores (β=10.59, 95% CI=3.76, 17.42) and total psychopathology scores (β= 6.13, 95% CI: 1.03, 11.23), were more likely to score above-threshold on the PQ positive symptoms scale (OR=4.00, 95% CI=1.08, 14.83), and had lower scores on the Social and Occupational Functioning Scale (β=-9.43, 95% CI=-15.08, -3.77) at follow-up. The FHx and TD groups did not differ on any outcome. Findings suggest that population screening for putative antecedents of schizophrenia may identify children who would benefit from preventative intervention.

Original language	English
Article number	83
Journal	Schizophrenia
Volume	10
Issue number	1
Early online date	30 Sept 2024
DOIs	https://doi.org/10.1038/s41537-024-00507-8
Publication status	Published - Dec 2024

Access to Document

10.1038/s41537-024-00507-8Licence: CC BY

Cullen_CHADS_Prodrome_AAM_06SEP2024Accepted author manuscript, 343 KBLicence: CC BY

Cite this

@article{dc9b0edbaed94b3d8205e13574ea00d8,

title = "Clinical and functional outcomes at 7-year follow-up of children presenting putative antecedents of schizophrenia at age 9-12 years",

abstract = "Identification of youth presenting early risk factors for psychosis may facilitate preventive intervention. Through school-based screening, we recruited 112 children aged 9-12 years who presented multiple putative antecedents of schizophrenia (ASz), a family history of schizophrenia (FHx), or neither of these risk factors (typically-developing; TD). Clinical and functional outcomes were assessed at age 17-21 years (N=93). Compared to the TD group, the ASz group had higher total Prodromal Questionnaire (PQ) scores (β=10.59, 95% CI=3.76, 17.42) and total psychopathology scores (β= 6.13, 95% CI: 1.03, 11.23), were more likely to score above-threshold on the PQ positive symptoms scale (OR=4.00, 95% CI=1.08, 14.83), and had lower scores on the Social and Occupational Functioning Scale (β=-9.43, 95% CI=-15.08, -3.77) at follow-up. The FHx and TD groups did not differ on any outcome. Findings suggest that population screening for putative antecedents of schizophrenia may identify children who would benefit from preventative intervention.",

author = "Alexis Cullen and Roberts, {Ruth E.} and Helen Fisher and Laurens, {Kristin R.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41537-024-00507-8",

language = "English",

volume = "10",

journal = "Schizophrenia",

issn = "2754-6993",

publisher = "Nature Research",

number = "1",

}

TY - JOUR

T1 - Clinical and functional outcomes at 7-year follow-up of children presenting putative antecedents of schizophrenia at age 9-12 years

AU - Cullen, Alexis

AU - Roberts, Ruth E.

AU - Fisher, Helen

AU - Laurens, Kristin R.

PY - 2024/12

Y1 - 2024/12

N2 - Identification of youth presenting early risk factors for psychosis may facilitate preventive intervention. Through school-based screening, we recruited 112 children aged 9-12 years who presented multiple putative antecedents of schizophrenia (ASz), a family history of schizophrenia (FHx), or neither of these risk factors (typically-developing; TD). Clinical and functional outcomes were assessed at age 17-21 years (N=93). Compared to the TD group, the ASz group had higher total Prodromal Questionnaire (PQ) scores (β=10.59, 95% CI=3.76, 17.42) and total psychopathology scores (β= 6.13, 95% CI: 1.03, 11.23), were more likely to score above-threshold on the PQ positive symptoms scale (OR=4.00, 95% CI=1.08, 14.83), and had lower scores on the Social and Occupational Functioning Scale (β=-9.43, 95% CI=-15.08, -3.77) at follow-up. The FHx and TD groups did not differ on any outcome. Findings suggest that population screening for putative antecedents of schizophrenia may identify children who would benefit from preventative intervention.

AB - Identification of youth presenting early risk factors for psychosis may facilitate preventive intervention. Through school-based screening, we recruited 112 children aged 9-12 years who presented multiple putative antecedents of schizophrenia (ASz), a family history of schizophrenia (FHx), or neither of these risk factors (typically-developing; TD). Clinical and functional outcomes were assessed at age 17-21 years (N=93). Compared to the TD group, the ASz group had higher total Prodromal Questionnaire (PQ) scores (β=10.59, 95% CI=3.76, 17.42) and total psychopathology scores (β= 6.13, 95% CI: 1.03, 11.23), were more likely to score above-threshold on the PQ positive symptoms scale (OR=4.00, 95% CI=1.08, 14.83), and had lower scores on the Social and Occupational Functioning Scale (β=-9.43, 95% CI=-15.08, -3.77) at follow-up. The FHx and TD groups did not differ on any outcome. Findings suggest that population screening for putative antecedents of schizophrenia may identify children who would benefit from preventative intervention.

UR - http://www.scopus.com/inward/record.url?scp=85205732854&partnerID=8YFLogxK

U2 - 10.1038/s41537-024-00507-8

DO - 10.1038/s41537-024-00507-8

M3 - Article

SN - 2754-6993

VL - 10

JO - Schizophrenia

JF - Schizophrenia

IS - 1

M1 - 83

ER -

Clinical and functional outcomes at 7-year follow-up of children presenting putative antecedents of schizophrenia at age 9-12 years

Abstract

Access to Document

Other files and links

Fingerprint

Cite this