Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia: Preliminary Report

Jerome R. Lechien*, Justin Michel, Thomas Radulesco, Carlos M. Chiesa-Estomba, Luigi A. Vaira, Giacomo De Riu, Leigh Sowerby, Claire Hopkins, Sven Saussez

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    42 Citations (Scopus)


    Objectives/Hypothesis: To investigate clinical and radiological features of olfactory clefts of patients with mild coronavirus disease 2019 (COVID-19). Study Design: Prospective non controlled study. Methods: Sixteen COVID-19 patients were recruited. The epidemiological and clinical data were extracted. Nasal complaints were assessed through the 22-item Sino-Nasal Outcome Test. Patients underwent psychophysical olfactory testing, olfactory cleft examination, and computed tomography (CT) scans. Results: Sixteen anosmic patients were included. The mean Sniffin' Sticks score was 4.6 ± 1.7. The majority of patients had no endoscopical abnormality, with a mean olfactory cleft endoscopy score of 0.6 ± 0.9. The olfactory clefts were opacified in three patients on the CT scan. The mean radiological olfactory cleft score was 0.7 ± 0.8. There were no significant correlations between clinical, radiological, and psychophysical olfactory testing. Conclusions: The olfactory cleft of anosmic COVID-19 patients is free regarding endoscopic examination and imaging. The anosmia etiology is not related to edema of the olfactory cleft. Level of Evidence: 4 Laryngoscope, 130:2526–2531, 2020.

    Original languageEnglish
    Pages (from-to)2526-2531
    Number of pages6
    Issue number11
    Publication statusPublished - 1 Nov 2020


    • anosmia
    • computed tomography scan
    • coronavirus
    • COVID-19
    • evaluation
    • imaging
    • olfaction
    • olfactory
    • smell
    • taste


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