Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia: Preliminary Report

Jerome R. Lechien; Justin Michel; Thomas Radulesco; Carlos M. Chiesa-Estomba; Luigi A. Vaira; Giacomo De Riu; Leigh Sowerby; Claire Hopkins; Sven Saussez

doi:10.1002/lary.28993

Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia: Preliminary Report

Jerome R. Lechien^*, Justin Michel, Thomas Radulesco, Carlos M. Chiesa-Estomba, Luigi A. Vaira, Giacomo De Riu, Leigh Sowerby, Claire Hopkins, Sven Saussez

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Objectives/Hypothesis: To investigate clinical and radiological features of olfactory clefts of patients with mild coronavirus disease 2019 (COVID-19). Study Design: Prospective non controlled study. Methods: Sixteen COVID-19 patients were recruited. The epidemiological and clinical data were extracted. Nasal complaints were assessed through the 22-item Sino-Nasal Outcome Test. Patients underwent psychophysical olfactory testing, olfactory cleft examination, and computed tomography (CT) scans. Results: Sixteen anosmic patients were included. The mean Sniffin' Sticks score was 4.6 ± 1.7. The majority of patients had no endoscopical abnormality, with a mean olfactory cleft endoscopy score of 0.6 ± 0.9. The olfactory clefts were opacified in three patients on the CT scan. The mean radiological olfactory cleft score was 0.7 ± 0.8. There were no significant correlations between clinical, radiological, and psychophysical olfactory testing. Conclusions: The olfactory cleft of anosmic COVID-19 patients is free regarding endoscopic examination and imaging. The anosmia etiology is not related to edema of the olfactory cleft. Level of Evidence: 4 Laryngoscope, 130:2526–2531, 2020.

Original language	English
Pages (from-to)	2526-2531
Number of pages	6
Journal	Laryngoscope
Volume	130
Issue number	11
DOIs	https://doi.org/10.1002/lary.28993
Publication status	Published - 1 Nov 2020

Keywords

anosmia
computed tomography scan
coronavirus
COVID-19
evaluation
imaging
olfaction
olfactory
smell
taste

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title = "Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia: Preliminary Report",

abstract = "Objectives/Hypothesis: To investigate clinical and radiological features of olfactory clefts of patients with mild coronavirus disease 2019 (COVID-19). Study Design: Prospective non controlled study. Methods: Sixteen COVID-19 patients were recruited. The epidemiological and clinical data were extracted. Nasal complaints were assessed through the 22-item Sino-Nasal Outcome Test. Patients underwent psychophysical olfactory testing, olfactory cleft examination, and computed tomography (CT) scans. Results: Sixteen anosmic patients were included. The mean Sniffin' Sticks score was 4.6 ± 1.7. The majority of patients had no endoscopical abnormality, with a mean olfactory cleft endoscopy score of 0.6 ± 0.9. The olfactory clefts were opacified in three patients on the CT scan. The mean radiological olfactory cleft score was 0.7 ± 0.8. There were no significant correlations between clinical, radiological, and psychophysical olfactory testing. Conclusions: The olfactory cleft of anosmic COVID-19 patients is free regarding endoscopic examination and imaging. The anosmia etiology is not related to edema of the olfactory cleft. Level of Evidence: 4 Laryngoscope, 130:2526–2531, 2020.",

keywords = "anosmia, computed tomography scan, coronavirus, COVID-19, evaluation, imaging, olfaction, olfactory, smell, taste",

author = "Lechien, {Jerome R.} and Justin Michel and Thomas Radulesco and Chiesa-Estomba, {Carlos M.} and Vaira, {Luigi A.} and {De Riu}, Giacomo and Leigh Sowerby and Claire Hopkins and Sven Saussez",

year = "2020",

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doi = "10.1002/lary.28993",

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T1 - Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia

T2 - Preliminary Report

AU - Lechien, Jerome R.

AU - Michel, Justin

AU - Radulesco, Thomas

AU - Chiesa-Estomba, Carlos M.

AU - Vaira, Luigi A.

AU - De Riu, Giacomo

AU - Sowerby, Leigh

AU - Hopkins, Claire

AU - Saussez, Sven

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Objectives/Hypothesis: To investigate clinical and radiological features of olfactory clefts of patients with mild coronavirus disease 2019 (COVID-19). Study Design: Prospective non controlled study. Methods: Sixteen COVID-19 patients were recruited. The epidemiological and clinical data were extracted. Nasal complaints were assessed through the 22-item Sino-Nasal Outcome Test. Patients underwent psychophysical olfactory testing, olfactory cleft examination, and computed tomography (CT) scans. Results: Sixteen anosmic patients were included. The mean Sniffin' Sticks score was 4.6 ± 1.7. The majority of patients had no endoscopical abnormality, with a mean olfactory cleft endoscopy score of 0.6 ± 0.9. The olfactory clefts were opacified in three patients on the CT scan. The mean radiological olfactory cleft score was 0.7 ± 0.8. There were no significant correlations between clinical, radiological, and psychophysical olfactory testing. Conclusions: The olfactory cleft of anosmic COVID-19 patients is free regarding endoscopic examination and imaging. The anosmia etiology is not related to edema of the olfactory cleft. Level of Evidence: 4 Laryngoscope, 130:2526–2531, 2020.

AB - Objectives/Hypothesis: To investigate clinical and radiological features of olfactory clefts of patients with mild coronavirus disease 2019 (COVID-19). Study Design: Prospective non controlled study. Methods: Sixteen COVID-19 patients were recruited. The epidemiological and clinical data were extracted. Nasal complaints were assessed through the 22-item Sino-Nasal Outcome Test. Patients underwent psychophysical olfactory testing, olfactory cleft examination, and computed tomography (CT) scans. Results: Sixteen anosmic patients were included. The mean Sniffin' Sticks score was 4.6 ± 1.7. The majority of patients had no endoscopical abnormality, with a mean olfactory cleft endoscopy score of 0.6 ± 0.9. The olfactory clefts were opacified in three patients on the CT scan. The mean radiological olfactory cleft score was 0.7 ± 0.8. There were no significant correlations between clinical, radiological, and psychophysical olfactory testing. Conclusions: The olfactory cleft of anosmic COVID-19 patients is free regarding endoscopic examination and imaging. The anosmia etiology is not related to edema of the olfactory cleft. Level of Evidence: 4 Laryngoscope, 130:2526–2531, 2020.

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KW - evaluation

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KW - taste

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ER -

Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia: Preliminary Report

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