Clinical and Translational Significance of Basophils in Patients with Cancer

Jitesh Chauhan; Chara Stavraka; Melanie Grandits; Lais Cristina Gusmao Ferreira; Debra Josephs; Katie Elizabeth Lacy; James Spicer; Heather Bax; Sophia N Karagiannis

doi:10.3390/cells11030438

Clinical and Translational Significance of Basophils in Patients with Cancer

Jitesh Chauhan, Chara Stavraka, Melanie Grandits, Lais Cristina Gusmao Ferreira, Debra Josephs, Katie Elizabeth Lacy, James Spicer, Heather Bax, Sophia N Karagiannis

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Abstract

Despite comprising a very small proportion of circulating blood leukocytes, basophils are potent immune effector cells. The high-affinity receptor for IgE (FcɛRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as histamine, granzyme B, and cytokines are stored in dense cytoplasmic granules, ready to be secreted in response to a range of immune stimuli. Basophils play key roles in eliciting potent effector functions in allergic diseases and type 1 hypersensitivity. Beyond allergies, basophils can be recruited to tissues in chronic and auto-immune inflammation, and in response to parasitic, bacterial, and viral infections. While their activation states and functions can be influenced by Th2-biased inflammatory signals, which are also known features of several tumor types, basophils have received little attention in cancer. Here, we discuss the presence and functional significance of basophils in the circulation of cancer patients and in the tumor microenvironment (TME). Interrogating publicly available datasets, we conduct gene expression analyses to explore basophil signatures and associations with clinical outcomes in several cancers. Furthermore, we assess how basophils can be harnessed to predict hypersensi-tivity to cancer treatments and to monitor the desensitization of patients to oncology drugs, using assays such as the basophil activation test (BAT).

Original language	English
Article number	438
Number of pages	20
Journal	Cells
Volume	11
Issue number	3
Early online date	27 Jan 2022
DOIs	https://doi.org/10.3390/cells11030438
Publication status	Published - 27 Jan 2022

Keywords

Allergooncology
Anaphylaxis
Basophil
Basophil activation test (BAT)
Cancer
Gene expression
IgE
Immunotherapy
Survival
Type I hypersensitivity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cells11030438

Chauhan et al cells-1522193 2022Accepted author manuscript, 1.29 MBLicence: CC BY

Cite this

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title = "Clinical and Translational Significance of Basophils in Patients with Cancer",

abstract = "Despite comprising a very small proportion of circulating blood leukocytes, basophils are potent immune effector cells. The high-affinity receptor for IgE (FcɛRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as histamine, granzyme B, and cytokines are stored in dense cytoplasmic granules, ready to be secreted in response to a range of immune stimuli. Basophils play key roles in eliciting potent effector functions in allergic diseases and type 1 hypersensitivity. Beyond allergies, basophils can be recruited to tissues in chronic and auto-immune inflammation, and in response to parasitic, bacterial, and viral infections. While their activation states and functions can be influenced by Th2-biased inflammatory signals, which are also known features of several tumor types, basophils have received little attention in cancer. Here, we discuss the presence and functional significance of basophils in the circulation of cancer patients and in the tumor microenvironment (TME). Interrogating publicly available datasets, we conduct gene expression analyses to explore basophil signatures and associations with clinical outcomes in several cancers. Furthermore, we assess how basophils can be harnessed to predict hypersensi-tivity to cancer treatments and to monitor the desensitization of patients to oncology drugs, using assays such as the basophil activation test (BAT).",

keywords = "Allergooncology, Anaphylaxis, Basophil, Basophil activation test (BAT), Cancer, Gene expression, IgE, Immunotherapy, Survival, Type I hypersensitivity",

author = "Jitesh Chauhan and Chara Stavraka and Melanie Grandits and {Gusmao Ferreira}, {Lais Cristina} and Debra Josephs and Lacy, {Katie Elizabeth} and James Spicer and Heather Bax and Karagiannis, {Sophia N}",

note = "Funding Information: The authors acknowledge support by Cancer Research UK (C30122/A11527; C30122/A15774); the Guy?s and St Thomas? Foundation Trust Charity Melanoma Special Fund (SPF573); CR UK//NIHR in England/DoH for Scotland, Wales and Northern Ireland Experimental Cancer Medicine Centre (C10355/A15587); Cancer Research UK King?s Health Partners Centre at King?s College London (C604/A25135); Breast Cancer Now (147; KCL-BCN-Q3); and the Medical Research Council (MR/L023091/1). The research was supported by the National Institute for Health Research Biomedical Research Centre based at Guy?s and St Thomas? NHS Foundation Trust and King?s College London (IS-BRC-1215-20006). The authors are solely responsible for the study design, data collection, analysis, decision to publish, and preparation of the manuscript. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/cells11030438",

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AU - Chauhan, Jitesh

AU - Stavraka, Chara

AU - Grandits, Melanie

AU - Gusmao Ferreira, Lais Cristina

AU - Josephs, Debra

AU - Lacy, Katie Elizabeth

AU - Spicer, James

AU - Bax, Heather

AU - Karagiannis, Sophia N

N1 - Funding Information: The authors acknowledge support by Cancer Research UK (C30122/A11527; C30122/A15774); the Guy?s and St Thomas? Foundation Trust Charity Melanoma Special Fund (SPF573); CR UK//NIHR in England/DoH for Scotland, Wales and Northern Ireland Experimental Cancer Medicine Centre (C10355/A15587); Cancer Research UK King?s Health Partners Centre at King?s College London (C604/A25135); Breast Cancer Now (147; KCL-BCN-Q3); and the Medical Research Council (MR/L023091/1). The research was supported by the National Institute for Health Research Biomedical Research Centre based at Guy?s and St Thomas? NHS Foundation Trust and King?s College London (IS-BRC-1215-20006). The authors are solely responsible for the study design, data collection, analysis, decision to publish, and preparation of the manuscript. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/1/27

Y1 - 2022/1/27

N2 - Despite comprising a very small proportion of circulating blood leukocytes, basophils are potent immune effector cells. The high-affinity receptor for IgE (FcɛRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as histamine, granzyme B, and cytokines are stored in dense cytoplasmic granules, ready to be secreted in response to a range of immune stimuli. Basophils play key roles in eliciting potent effector functions in allergic diseases and type 1 hypersensitivity. Beyond allergies, basophils can be recruited to tissues in chronic and auto-immune inflammation, and in response to parasitic, bacterial, and viral infections. While their activation states and functions can be influenced by Th2-biased inflammatory signals, which are also known features of several tumor types, basophils have received little attention in cancer. Here, we discuss the presence and functional significance of basophils in the circulation of cancer patients and in the tumor microenvironment (TME). Interrogating publicly available datasets, we conduct gene expression analyses to explore basophil signatures and associations with clinical outcomes in several cancers. Furthermore, we assess how basophils can be harnessed to predict hypersensi-tivity to cancer treatments and to monitor the desensitization of patients to oncology drugs, using assays such as the basophil activation test (BAT).

AB - Despite comprising a very small proportion of circulating blood leukocytes, basophils are potent immune effector cells. The high-affinity receptor for IgE (FcɛRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as histamine, granzyme B, and cytokines are stored in dense cytoplasmic granules, ready to be secreted in response to a range of immune stimuli. Basophils play key roles in eliciting potent effector functions in allergic diseases and type 1 hypersensitivity. Beyond allergies, basophils can be recruited to tissues in chronic and auto-immune inflammation, and in response to parasitic, bacterial, and viral infections. While their activation states and functions can be influenced by Th2-biased inflammatory signals, which are also known features of several tumor types, basophils have received little attention in cancer. Here, we discuss the presence and functional significance of basophils in the circulation of cancer patients and in the tumor microenvironment (TME). Interrogating publicly available datasets, we conduct gene expression analyses to explore basophil signatures and associations with clinical outcomes in several cancers. Furthermore, we assess how basophils can be harnessed to predict hypersensi-tivity to cancer treatments and to monitor the desensitization of patients to oncology drugs, using assays such as the basophil activation test (BAT).

KW - Allergooncology

KW - Anaphylaxis

KW - Basophil

KW - Basophil activation test (BAT)

KW - Cancer

KW - Gene expression

KW - IgE

KW - Immunotherapy

KW - Survival

KW - Type I hypersensitivity

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U2 - 10.3390/cells11030438

DO - 10.3390/cells11030438

M3 - Article

C2 - 35159247

AN - SCOPUS:85123366430

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 3

M1 - 438

ER -

Clinical and Translational Significance of Basophils in Patients with Cancer

Abstract

Keywords

UN SDGs

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