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Clinical Applications for Diffusion MRI and Tractography of Cranial Nerves Within the Posterior Fossa: A Systematic Review

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Clinical Applications for Diffusion MRI and Tractography of Cranial Nerves Within the Posterior Fossa: A Systematic Review. / Shapey, Jonathan; Vos, Sjoerd B.; Vercauteren, Tom; Bradford, Robert; Saeed, Shakeel R.; Bisdas, Sotirios; Ourselin, Sebastien.

In: Frontiers in Neuroscience, Vol. 13, No. FEB, 23, 07.02.2019.

Research output: Contribution to journalReview article

Harvard

Shapey, J, Vos, SB, Vercauteren, T, Bradford, R, Saeed, SR, Bisdas, S & Ourselin, S 2019, 'Clinical Applications for Diffusion MRI and Tractography of Cranial Nerves Within the Posterior Fossa: A Systematic Review', Frontiers in Neuroscience, vol. 13, no. FEB, 23. https://doi.org/10.3389/fnins.2019.00023

APA

Shapey, J., Vos, S. B., Vercauteren, T., Bradford, R., Saeed, S. R., Bisdas, S., & Ourselin, S. (2019). Clinical Applications for Diffusion MRI and Tractography of Cranial Nerves Within the Posterior Fossa: A Systematic Review. Frontiers in Neuroscience, 13(FEB), [23]. https://doi.org/10.3389/fnins.2019.00023

Vancouver

Shapey J, Vos SB, Vercauteren T, Bradford R, Saeed SR, Bisdas S et al. Clinical Applications for Diffusion MRI and Tractography of Cranial Nerves Within the Posterior Fossa: A Systematic Review. Frontiers in Neuroscience. 2019 Feb 7;13(FEB). 23. https://doi.org/10.3389/fnins.2019.00023

Author

Shapey, Jonathan ; Vos, Sjoerd B. ; Vercauteren, Tom ; Bradford, Robert ; Saeed, Shakeel R. ; Bisdas, Sotirios ; Ourselin, Sebastien. / Clinical Applications for Diffusion MRI and Tractography of Cranial Nerves Within the Posterior Fossa: A Systematic Review. In: Frontiers in Neuroscience. 2019 ; Vol. 13, No. FEB.

Bibtex Download

@article{435805682b75499c92aacd03635d0cf1,
title = "Clinical Applications for Diffusion MRI and Tractography of Cranial Nerves Within the Posterior Fossa: A Systematic Review",
abstract = "Objective: This paper presents a systematic review of diffusion MRI (dMRI) and tractography of cranial nerves within the posterior fossa. We assess the effectiveness of the diffusion imaging methods used and examine their clinical applications.Methods: The Pubmed, Web of Science and EMBASE databases were searched from January 1st 1997 to December 11th 2017 to identify relevant publications. Any study reporting the use of diffusion imaging and/or tractography in patients with confirmed cranial nerve pathology was eligible for selection. Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS) tool.Results: We included 41 studies comprising 16 studies of patients with trigeminal neuralgia (TN), 22 studies of patients with a posterior fossa tumor and three studies of patients with other pathologies. Most acquisition protocols used single-shot echo planar imaging (88%) with a single b-value of 1,000 s/mm2 (78%) but there was significant variation in the number of gradient directions, in-plane resolution, and slice thickness between studies. dMRI of the trigeminal nerve generated interpretable data in all cases. Analysis of diffusivity measurements found significantly lower fractional anisotropy (FA) values within the root entry zone of nerves affected by TN and FA values were significantly lower in patients with multiple sclerosis. Diffusivity values within the trigeminal nerve correlate with the effectiveness of surgical treatment and there is some evidence that pre-operative measurements may be predictive of treatment outcome. Fiber tractography was performed in 30 studies (73%). Most studies evaluating fiber tractography involved patients with a vestibular schwannoma (82%) and focused on generating tractography of the facial nerve to assist with surgical planning. Deterministic tractography using diffusion tensor imaging was performed in 93% of cases but the reported success rate and accuracy of generating fiber tracts from the acquired diffusion data varied considerably.Conclusions: dMRI has the potential to inform our understanding of the microstructural changes that occur within the cranial nerves in various pathologies. Cranial nerve tractography is a promising technique but new avenues of using dMRI should be explored to optimize and improve its reliability.",
keywords = "Brain tumors, Cranial nerves, Diffusion MRI (dMRI), MRI-magnetic resonance imaging, Tractography, Trigeminal neuralgia (TN)",
author = "Jonathan Shapey and Vos, {Sjoerd B.} and Tom Vercauteren and Robert Bradford and Saeed, {Shakeel R.} and Sotirios Bisdas and Sebastien Ourselin",
year = "2019",
month = feb,
day = "7",
doi = "10.3389/fnins.2019.00023",
language = "English",
volume = "13",
journal = "Frontiers in Neuroscience",
issn = "1662-453X",
publisher = "Frontiers Media S.A.",
number = "FEB",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Clinical Applications for Diffusion MRI and Tractography of Cranial Nerves Within the Posterior Fossa: A Systematic Review

AU - Shapey, Jonathan

AU - Vos, Sjoerd B.

AU - Vercauteren, Tom

AU - Bradford, Robert

AU - Saeed, Shakeel R.

AU - Bisdas, Sotirios

AU - Ourselin, Sebastien

PY - 2019/2/7

Y1 - 2019/2/7

N2 - Objective: This paper presents a systematic review of diffusion MRI (dMRI) and tractography of cranial nerves within the posterior fossa. We assess the effectiveness of the diffusion imaging methods used and examine their clinical applications.Methods: The Pubmed, Web of Science and EMBASE databases were searched from January 1st 1997 to December 11th 2017 to identify relevant publications. Any study reporting the use of diffusion imaging and/or tractography in patients with confirmed cranial nerve pathology was eligible for selection. Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS) tool.Results: We included 41 studies comprising 16 studies of patients with trigeminal neuralgia (TN), 22 studies of patients with a posterior fossa tumor and three studies of patients with other pathologies. Most acquisition protocols used single-shot echo planar imaging (88%) with a single b-value of 1,000 s/mm2 (78%) but there was significant variation in the number of gradient directions, in-plane resolution, and slice thickness between studies. dMRI of the trigeminal nerve generated interpretable data in all cases. Analysis of diffusivity measurements found significantly lower fractional anisotropy (FA) values within the root entry zone of nerves affected by TN and FA values were significantly lower in patients with multiple sclerosis. Diffusivity values within the trigeminal nerve correlate with the effectiveness of surgical treatment and there is some evidence that pre-operative measurements may be predictive of treatment outcome. Fiber tractography was performed in 30 studies (73%). Most studies evaluating fiber tractography involved patients with a vestibular schwannoma (82%) and focused on generating tractography of the facial nerve to assist with surgical planning. Deterministic tractography using diffusion tensor imaging was performed in 93% of cases but the reported success rate and accuracy of generating fiber tracts from the acquired diffusion data varied considerably.Conclusions: dMRI has the potential to inform our understanding of the microstructural changes that occur within the cranial nerves in various pathologies. Cranial nerve tractography is a promising technique but new avenues of using dMRI should be explored to optimize and improve its reliability.

AB - Objective: This paper presents a systematic review of diffusion MRI (dMRI) and tractography of cranial nerves within the posterior fossa. We assess the effectiveness of the diffusion imaging methods used and examine their clinical applications.Methods: The Pubmed, Web of Science and EMBASE databases were searched from January 1st 1997 to December 11th 2017 to identify relevant publications. Any study reporting the use of diffusion imaging and/or tractography in patients with confirmed cranial nerve pathology was eligible for selection. Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS) tool.Results: We included 41 studies comprising 16 studies of patients with trigeminal neuralgia (TN), 22 studies of patients with a posterior fossa tumor and three studies of patients with other pathologies. Most acquisition protocols used single-shot echo planar imaging (88%) with a single b-value of 1,000 s/mm2 (78%) but there was significant variation in the number of gradient directions, in-plane resolution, and slice thickness between studies. dMRI of the trigeminal nerve generated interpretable data in all cases. Analysis of diffusivity measurements found significantly lower fractional anisotropy (FA) values within the root entry zone of nerves affected by TN and FA values were significantly lower in patients with multiple sclerosis. Diffusivity values within the trigeminal nerve correlate with the effectiveness of surgical treatment and there is some evidence that pre-operative measurements may be predictive of treatment outcome. Fiber tractography was performed in 30 studies (73%). Most studies evaluating fiber tractography involved patients with a vestibular schwannoma (82%) and focused on generating tractography of the facial nerve to assist with surgical planning. Deterministic tractography using diffusion tensor imaging was performed in 93% of cases but the reported success rate and accuracy of generating fiber tracts from the acquired diffusion data varied considerably.Conclusions: dMRI has the potential to inform our understanding of the microstructural changes that occur within the cranial nerves in various pathologies. Cranial nerve tractography is a promising technique but new avenues of using dMRI should be explored to optimize and improve its reliability.

KW - Brain tumors

KW - Cranial nerves

KW - Diffusion MRI (dMRI)

KW - MRI-magnetic resonance imaging

KW - Tractography

KW - Trigeminal neuralgia (TN)

UR - http://www.scopus.com/inward/record.url?scp=85065850473&partnerID=8YFLogxK

U2 - 10.3389/fnins.2019.00023

DO - 10.3389/fnins.2019.00023

M3 - Review article

VL - 13

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-453X

IS - FEB

M1 - 23

ER -

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