Clinical Assessment of MR-Assisted PET Image Reconstruction Algorithms for Low-Dose Brain PET Imaging

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

3 Citations (Scopus)

Abstract

This work aims to evaluate the impact of lowering PET dose on image quality and diagnostic confidence of PET images reconstructed by filtered back-projection (FBP), standard maximum-likelihood expectation-maximization (MLEM) and advanced MR-assisted methods such as kernel EM (KEM) and maximum a posteriori EM (MAPEM). List-mode FDG PET data from 5 patients were thinned into count levels of 50% down to just 1% of the full data. The impact of post-reconstruction smoothing on clinical rating of standard-dose PET images was also evaluated. An adaptive post-reconstruction smoothing was devised for each reconstruction and dose level. For 50% dose reduction, all methods maintained the same overall image quality as full-dose ones. For dose levels <25%, image quality deteriorated for FBP and MLEM, while KEM and MAPEM permitted this limit to be further reduced down to 5-10% of the standard dose, corresponding to injected activities of 10-20 MBq. Post-reconstruction smoothing levels up to about 8 mm did not notably affect the diagnostic task of assessing broadly varying FDG uptake patterns in the brain, thereby indicating a dose level lower than the standard one could be administered. In conclusion, these preliminary results suggest that current MR-assisted methods may allow notably reduced injected doses for PET-MR, at least down to 10%, for clinical tasks requiring broad pattern recognition, such as used in assessment of dementia.

Original languageEnglish
Title of host publication2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728141640
DOIs
Publication statusPublished - Oct 2019
Event2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019 - Manchester, United Kingdom
Duration: 26 Oct 20192 Nov 2019

Publication series

Name2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019

Conference

Conference2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
Country/TerritoryUnited Kingdom
CityManchester
Period26/10/20192/11/2019

Fingerprint

Dive into the research topics of 'Clinical Assessment of MR-Assisted PET Image Reconstruction Algorithms for Low-Dose Brain PET Imaging'. Together they form a unique fingerprint.

Cite this