Clinical Diagnostic Biomarkers from the Personalization of Computational Models of Cardiac Physiology

TY - JOUR

T1 - Clinical Diagnostic Biomarkers from the Personalization of Computational Models of Cardiac Physiology

AU - Lamata, Pablo

AU - Cookson, Andrew

AU - Smith, Ni

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Computational modelling of the heart is rapidly advancing to the point of clinical utility. However, the difficulty of parameterizing and validating models from clinical data indicates that the routine application of truly predictive models remains a significant challenge. We argue there is significant value in an intermediate step towards prediction. This step is the use of biophysically based models to extract clinically useful information from existing patient data. Specifically in this paper we review methodologies for applying modelling frameworks for this goal in the areas of quantifying cardiac anatomy, estimating myocardial stiffness and optimizing measurements of coronary perfusion. Using these indicative examples of the general overarching approach, we finally discuss the value, ongoing challenges and future potential for applying biophysically based modelling in the clinical context.

AB - Computational modelling of the heart is rapidly advancing to the point of clinical utility. However, the difficulty of parameterizing and validating models from clinical data indicates that the routine application of truly predictive models remains a significant challenge. We argue there is significant value in an intermediate step towards prediction. This step is the use of biophysically based models to extract clinically useful information from existing patient data. Specifically in this paper we review methodologies for applying modelling frameworks for this goal in the areas of quantifying cardiac anatomy, estimating myocardial stiffness and optimizing measurements of coronary perfusion. Using these indicative examples of the general overarching approach, we finally discuss the value, ongoing challenges and future potential for applying biophysically based modelling in the clinical context.

KW - Anatomy

KW - Cardiac computational models

KW - Clinical biomarker

KW - Coronary flow

KW - Myocardial stiffness

U2 - 10.1007/s10439-015-1439-8

DO - 10.1007/s10439-015-1439-8

M3 - Article

SN - 0090-6964

VL - 44

SP - 46

EP - 57

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

ER -