Clinical diagnostic criteria for dementia associated with Parkinson's disease

TY - JOUR

T1 - Clinical diagnostic criteria for dementia associated with Parkinson's disease

AU - Emre, M

AU - Aarsland, D

AU - Brown, R

AU - Bum, D J

AU - Duyckaerts, C

AU - Mizuno, Y

AU - Broe, G A

AU - Cummings, J

AU - Dickson, D W

AU - Gauthier, S

AU - Goldman, J

AU - Goetz, C

AU - Korczyn, A

AU - Lees, A

AU - Levy, R

AU - Litvan, I

AU - McKeith, I

AU - Olanow, W

AU - Poewe, W

AU - Quinn, N

AU - Sampaio, C

AU - Tolosa, E

AU - Dubois, B

PY - 2007/9/15

Y1 - 2007/9/15

N2 - Dementia has been increasingly more recognized to be a common feature in patients with Parkinson's disease (PD), especially in old age. Specific criteria for the clinical diagnosis of dementia associated with PD (PD-D), however, have been lacking. A Task Force, organized by the Movement Disorder Study, was charged with the development of clinical diagnostic criteria for PD-D. The Task Force members were assigned to sub-committees and performed a systematic review of the literature, based on pre-defined selection criteria, in order to identify the epidemiological, clinical, auxillary, and pathological features of PD-D. Clinical diagnostic criteria were then developed based on these findings and group consensus. The incidence of dementia in PD is increased up to six times, point-prevelance is close to 30%, older age and akinetic-rigid form are associated with higher risk. PD-D is characterized by impairment in attention, memory, executive and visuo-spatial functions, behavioral symptoms such as affective changes, hallucinations, and apathy are frequent. There are no specific ancillary investigations for the diagnosis; the main pathological correlate is Lewy body-type degeneration in cerebral cortex and limbic structures. Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed. (C) 2007 Movement Disorder Society

AB - Dementia has been increasingly more recognized to be a common feature in patients with Parkinson's disease (PD), especially in old age. Specific criteria for the clinical diagnosis of dementia associated with PD (PD-D), however, have been lacking. A Task Force, organized by the Movement Disorder Study, was charged with the development of clinical diagnostic criteria for PD-D. The Task Force members were assigned to sub-committees and performed a systematic review of the literature, based on pre-defined selection criteria, in order to identify the epidemiological, clinical, auxillary, and pathological features of PD-D. Clinical diagnostic criteria were then developed based on these findings and group consensus. The incidence of dementia in PD is increased up to six times, point-prevelance is close to 30%, older age and akinetic-rigid form are associated with higher risk. PD-D is characterized by impairment in attention, memory, executive and visuo-spatial functions, behavioral symptoms such as affective changes, hallucinations, and apathy are frequent. There are no specific ancillary investigations for the diagnosis; the main pathological correlate is Lewy body-type degeneration in cerebral cortex and limbic structures. Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed. (C) 2007 Movement Disorder Society

U2 - 10.1002/mds.21507

DO - 10.1002/mds.21507

M3 - Literature review

VL - 22

SP - 1689

EP - 1707

JO - Movement Disorders

JF - Movement Disorders

IS - 12

ER -