Clinical efficacy of galvanic skin response biofeedback training in reducing seizures in adult epilepsy: a preliminary randomized controlled study

Y Nagai, L H Goldstein, P B C Fenwick, M R Trimble

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)

Abstract

We investigated the effect of galvanic skin response (GSR) biofeedback training on seizure frequency in patients with treatment-resistant epilepsy. Eighteen patients with drug-refractory epilepsy were randomly assigned either to an active GSR biofeedback group (n = 10) or to a sham control biofeedback group (n = 8). Biofeedback training significantly reduced seizure frequency in the active biofeedback group (P = 0.017), but not the control group (P > 0.10). This was manifest as a significant between-group difference in seizure reduction (P = 0.01). Furthermore, there was a correlation between degree of improvement in biofeedback performance and reduction of seizure frequency (p = 0.736, P = 0.001), confirming that the effect of biofeedback treatment was related to physiological change. Our findings highlight the potential therapeutic value of GSR biofeedback in reducing seizure frequency in patients with drug-resistant epilepsy. (C) 2004 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)216 - 223
Number of pages8
JournalEpilepsy & Behavior
Volume5
Issue number2
DOIs
Publication statusPublished - Apr 2004

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