Clinical interventions for treatment non-adherence in psychosis: meta-analysis

M Nose, C Barbui, R Gray, M Tansella

Research output: Contribution to journalLiterature reviewpeer-review

146 Citations (Scopus)


Background Studies investigating the efficacy of clinical interventions for reducing treatment non-adherence have generated contrasting findings, and treatment non-adherence remains common in clinical practice. Aims To systematically review whether there are effective clinical interventions that community psychiatric services can implement to reduce non-adherence. Method Systematic review and meta-regression analysis of randomised controlled trials (RCTs) and controlled clinical trials (CCTs) were used to assess the efficacy of interventions to enhance adherence. Results We reviewed 24 studies, more than half of which were RCTs. In 14 studies the experimental intervention was an educational programme. Five studies evaluated pre-discharge educational sessions, three studies explored the benefit of psychotherapeutic interventions and two studies looked at the effect of telephone prompts. The overall estimate of the efficacy of these interventions produced an odds ratio of 2.59 (95% Cl 2.21-3.03) for dichotomous outcomes, and a stanclardised mean difference of 0.36 (95% Cl 0.06-0.66) for continuous outcomes. Conclusions Community psychiatric services can potentially use effective clinical interventions, backed by scientific evidence, for reducing patient non-adherence. Declaration of interest None.
Original languageEnglish
Pages (from-to)197 - 206
Number of pages10
JournalBritish Journal of Psychiatry
Issue numberSEPT.
Publication statusPublished - 1 Sept 2003


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