Clinical outcomes in relapsed oropharyngeal cancer after definitive (chemo)radiotherapy

Francesca De Felice; Thomas Bird; Andriana Michaelidou; Jean-Pierre Jeannon; Ricard Simo; Richard Oakley; Andrew Lyons; Alastair Fry; Luke Cascarini; Arora Asit; Selvam Thavaraj; Miguel Reis Ferreira; Imran Petkar; Anthony Kong; Mary Lei; Teresa Guerrero Urbano

doi:10.1111/odi.13985

Clinical outcomes in relapsed oropharyngeal cancer after definitive (chemo)radiotherapy

Francesca De Felice, Thomas Bird, Andriana Michaelidou, Jean-Pierre Jeannon, Ricard Simo, Richard Oakley, Andrew Lyons, Alastair Fry, Luke Cascarini, Arora Asit, Selvam Thavaraj, Miguel Reis Ferreira, Imran Petkar, Anthony Kong, Mary Lei, Teresa Guerrero Urbano

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Objectives: To report clinical outcomes of relapsed oropharyngeal squamous cell carcinoma (OPSCC) after definitive intensity-modulated (chemo)radiotherapy [(C)RT]. Materials and methods: Data for all relapsed patients treated for OPSCC with definitive (C)RT between 2010 and 2016 were collected. Primary end-point was post-failure survival (PFS). Results: Overall, 273 OPSCC patients completed definitive (C)RT. Of these, 42 cases (n = 26 human papilloma virus (HPV)-negative; n = 16 HPV-positive) had relapsed (n = 23 persistent disease; n = 19 recurrent disease) and were included in the final analysis. Two-year PFS for the entire population was 30.6%; 20.5% for HPV-negative and 43.8% for HPV-positive patients. Salvage curative surgery was associated with a significantly higher 2 years PFS rate (56.2%) compared with palliative treatment (22.9%) and best supportive care (0%) (p < 0.001). A positive trend in 2 years PFS was recorded in the early complete response cases (49.5%) versus patients who did not achieve a complete response within 3 months of the end of (C)RT (23.0%) (p = 0.11). Conclusion: A higher PFS rate is achieved when relapsed OPSCC cases are treated with salvage curative intent. HPV-positive disease and early complete response within 3 months from the end of (C)RT may be related to better PFS.

Original language	English
Journal	Oral Diseases
DOIs	https://doi.org/10.1111/odi.13985
Publication status	E-pub ahead of print - 27 Aug 2021

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10.1111/odi.13985

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De Felice, F., Bird, T., Michaelidou, A., Jeannon, J.-P., Simo, R., Oakley, R., Lyons, A., Fry, A., Cascarini, L., Asit, A., Thavaraj, S., Reis Ferreira, M., Petkar, I., Kong, A., Lei, M., & Guerrero Urbano, T. (2021). Clinical outcomes in relapsed oropharyngeal cancer after definitive (chemo)radiotherapy. Oral Diseases. Advance online publication. https://doi.org/10.1111/odi.13985

@article{36f7b6b243cc492e80cc630f2cd795b9,

title = "Clinical outcomes in relapsed oropharyngeal cancer after definitive (chemo)radiotherapy",

abstract = "Objectives: To report clinical outcomes of relapsed oropharyngeal squamous cell carcinoma (OPSCC) after definitive intensity-modulated (chemo)radiotherapy [(C)RT]. Materials and methods: Data for all relapsed patients treated for OPSCC with definitive (C)RT between 2010 and 2016 were collected. Primary end-point was post-failure survival (PFS). Results: Overall, 273 OPSCC patients completed definitive (C)RT. Of these, 42 cases (n = 26 human papilloma virus (HPV)-negative; n = 16 HPV-positive) had relapsed (n = 23 persistent disease; n = 19 recurrent disease) and were included in the final analysis. Two-year PFS for the entire population was 30.6%; 20.5% for HPV-negative and 43.8% for HPV-positive patients. Salvage curative surgery was associated with a significantly higher 2 years PFS rate (56.2%) compared with palliative treatment (22.9%) and best supportive care (0%) (p < 0.001). A positive trend in 2 years PFS was recorded in the early complete response cases (49.5%) versus patients who did not achieve a complete response within 3 months of the end of (C)RT (23.0%) (p = 0.11). Conclusion: A higher PFS rate is achieved when relapsed OPSCC cases are treated with salvage curative intent. HPV-positive disease and early complete response within 3 months from the end of (C)RT may be related to better PFS.",

author = "{De Felice}, Francesca and Thomas Bird and Andriana Michaelidou and Jean-Pierre Jeannon and Ricard Simo and Richard Oakley and Andrew Lyons and Alastair Fry and Luke Cascarini and Arora Asit and Selvam Thavaraj and {Reis Ferreira}, Miguel and Imran Petkar and Anthony Kong and Mary Lei and {Guerrero Urbano}, Teresa",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2021",

month = aug,

day = "27",

doi = "10.1111/odi.13985",

language = "English",

journal = "Oral Diseases",

issn = "1354-523X",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Clinical outcomes in relapsed oropharyngeal cancer after definitive (chemo)radiotherapy

AU - De Felice, Francesca

AU - Bird, Thomas

AU - Michaelidou, Andriana

AU - Jeannon, Jean-Pierre

AU - Simo, Ricard

AU - Oakley, Richard

AU - Lyons, Andrew

AU - Fry, Alastair

AU - Cascarini, Luke

AU - Asit, Arora

AU - Thavaraj, Selvam

AU - Reis Ferreira, Miguel

AU - Petkar, Imran

AU - Kong, Anthony

AU - Lei, Mary

AU - Guerrero Urbano, Teresa

PY - 2021/8/27

Y1 - 2021/8/27

N2 - Objectives: To report clinical outcomes of relapsed oropharyngeal squamous cell carcinoma (OPSCC) after definitive intensity-modulated (chemo)radiotherapy [(C)RT]. Materials and methods: Data for all relapsed patients treated for OPSCC with definitive (C)RT between 2010 and 2016 were collected. Primary end-point was post-failure survival (PFS). Results: Overall, 273 OPSCC patients completed definitive (C)RT. Of these, 42 cases (n = 26 human papilloma virus (HPV)-negative; n = 16 HPV-positive) had relapsed (n = 23 persistent disease; n = 19 recurrent disease) and were included in the final analysis. Two-year PFS for the entire population was 30.6%; 20.5% for HPV-negative and 43.8% for HPV-positive patients. Salvage curative surgery was associated with a significantly higher 2 years PFS rate (56.2%) compared with palliative treatment (22.9%) and best supportive care (0%) (p < 0.001). A positive trend in 2 years PFS was recorded in the early complete response cases (49.5%) versus patients who did not achieve a complete response within 3 months of the end of (C)RT (23.0%) (p = 0.11). Conclusion: A higher PFS rate is achieved when relapsed OPSCC cases are treated with salvage curative intent. HPV-positive disease and early complete response within 3 months from the end of (C)RT may be related to better PFS.

AB - Objectives: To report clinical outcomes of relapsed oropharyngeal squamous cell carcinoma (OPSCC) after definitive intensity-modulated (chemo)radiotherapy [(C)RT]. Materials and methods: Data for all relapsed patients treated for OPSCC with definitive (C)RT between 2010 and 2016 were collected. Primary end-point was post-failure survival (PFS). Results: Overall, 273 OPSCC patients completed definitive (C)RT. Of these, 42 cases (n = 26 human papilloma virus (HPV)-negative; n = 16 HPV-positive) had relapsed (n = 23 persistent disease; n = 19 recurrent disease) and were included in the final analysis. Two-year PFS for the entire population was 30.6%; 20.5% for HPV-negative and 43.8% for HPV-positive patients. Salvage curative surgery was associated with a significantly higher 2 years PFS rate (56.2%) compared with palliative treatment (22.9%) and best supportive care (0%) (p < 0.001). A positive trend in 2 years PFS was recorded in the early complete response cases (49.5%) versus patients who did not achieve a complete response within 3 months of the end of (C)RT (23.0%) (p = 0.11). Conclusion: A higher PFS rate is achieved when relapsed OPSCC cases are treated with salvage curative intent. HPV-positive disease and early complete response within 3 months from the end of (C)RT may be related to better PFS.

UR - http://www.scopus.com/inward/record.url?scp=85113554044&partnerID=8YFLogxK

U2 - 10.1111/odi.13985

DO - 10.1111/odi.13985

M3 - Article

C2 - 34338394

SN - 1354-523X

JO - Oral Diseases

JF - Oral Diseases

ER -

Clinical outcomes in relapsed oropharyngeal cancer after definitive (chemo)radiotherapy

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