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Clinical PET With A Large Area Multiwire Proportional Chamber PET Camera

Research output: Contribution to journalArticlepeer-review

R. J. Ott, P. K. Marsden, M. A. Flower, S. Webb, S. Cherry, V. R. McCready, J. E. Bateman

Original languageEnglish
Pages (from-to)436-442
Number of pages7
JournalNuclear Instruments & Methods In Physics Research Section A, Accelerators, Spectrometers, Detectors And Associated Equipment
Issue number2
Published10 Jun 1988

Bibliographical note

M1 - 2 Times Cited: 28

King's Authors


A large-area multiwire proportional chamber positron camera (MUP-PET) is under evaluation for clinical nuclear medicine use remote from a medical cyclotron. A preliminary physical evaluation shows that the detector has a sensitivity 5–10 times that of a conventional gamma camera but one tenth that of a multicrystal, multiring PET system. The spatial resolution is 6 mm throughout an imaging volume 40 cm diameter by 20 cm axially. The electronic readout presently limits the data acquisition rates to ∼ 2–3 kcps. The system has potential to acquire data at 50 kcps with a further increase in sensitivity of 5–10 and an improved resolution of 3 mm. The camera is under evaluation for clinical use in oncological studies using radiopharmaceuticals labelled with 68Ga from an in-house generator plus longer-lived radionuclides (18F, 124I, 55Co, 68Ga) from off-site cyclotrons. In particular quantitative measurements of dosimetry in both chemotherapy and radiotherapy will be an important part of the work.

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