Clinical presentation and initial management of Black men and White men with prostate cancer in the United Kingdom: the PROCESS cohort study

S. Evans, C. Metcalfe, B. Patel, F. Ibrahim, K. Anson, F. Chinegwundoh, C. Corbishley, D. Gillatt, R. Kirby, Gordon Muir, V. Nargund, Rick Popert, P. Wilson, R. Persad, Y. Ben-Shlomo*, PROC Study Grp

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    BACKGROUND: In the United States, Black men have a higher risk of prostate cancer and worse survival than do White men, but it is unclear whether this is because of differences in diagnosis and management. We re-examined these differences in the United Kingdom, where health care is free and unlikely to vary by socioeconomic status.

    METHODS: This study is a population-based retrospective cohort study of men diagnosed with prostate cancer with data on ethnicity, prognostic factors, and clinical care. A Delphi panel considered the appropriateness of investigations and treatments received.

    RESULTS: At diagnosis, Black men had similar clinical stage and Gleason scores but higher age-adjusted prostate-specific antigen levels (geometric mean ratio 1.41, 95% confidence interval (95% CI): 1.15-1.73). Black men underwent more investigations and were more likely to undergo radical treatment, although this was largely explained by their younger age. Even after age adjustment, Black men were more likely to undergo a bone scan (odds ratio 1.37, 95% CI: 1.05-1.80). The Delphi analysis did not suggest differential management by ethnicity.

    CONCLUSIONS: This UK-based study comparing Black men with White men found no evidence of differences in disease characteristics at the time of prostate cancer diagnosis, nor of under-investigation or under-treatment in Black men. British Journal of Cancer (2010) 102, 249-254. doi:10.1038/sj.bjc.6605461 www.bjcancer.com Published online 24 November 2009 (C) 2010 Cancer Research UK

    Original languageEnglish
    Pages (from-to)249-254
    Number of pages6
    JournalBJC: British Journal of Cancer
    Volume102
    Issue number2
    DOIs
    Publication statusPublished - 19 Jan 2010

    Keywords

    • clinical management
    • diagnosis
    • epidemiology
    • ethnicity
    • prostate cancer
    • DIAGNOSIS
    • RACE/ETHNICITY
    • RECEIPT

    Fingerprint

    Dive into the research topics of 'Clinical presentation and initial management of Black men and White men with prostate cancer in the United Kingdom: the PROCESS cohort study'. Together they form a unique fingerprint.

    Cite this