Clinical significance of hypoxia in nasopharyngeal carcinoma with a focus on existing and novel hypoxia molecular imaging

Connie Yip*, Gary Cook, Joseph Wee, Kam Weng Fong, Terence Tan, Vicky Goh

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
366 Downloads (Pure)

Abstract

Locally advanced nasopharyngeal carcinoma (NPC) is still associated with significant locoregional failure and poor overall survival (OS) after chemoradiation. The maximal therapeutic effect of conventional chemotherapy combined with radiation may have been reached and there is a clinical need to identify additional adverse prognostic factors that could be targeted therapeutically. Hypoxia, a known prognostic factor in head and neck cancers is an attractive target in NPC with various treatment strategies available such as hypoxic cell sensitisers/cytotoxins and increasing intratumoral oxygen delivery, to overcome the poorer outcomes associated with this phenotype. Thus, we aim to review the clinical significance of hypoxia as well as the current and future of molecular hypoxia imaging in NPC.

Original languageEnglish
Article number24
JournalChinese Clinical Oncology
Volume5
Issue number2
DOIs
Publication statusPublished - 1 Apr 2016

Keywords

  • Hypoxia
  • Magnetic resonance imaging (MRI)
  • Nasopharyngeal carcinoma (NPC)
  • Positron emission tomography (PET)
  • Single photon emission computed tomography (SPECT)

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