TY - JOUR
T1 - Clinical significance of incidental finding of focal activity in the breast on 18F-FDG PET/CT scan
AU - Sinha, Richa
AU - Suaris, Tamara
AU - O'Doherty, James
AU - Szyszko, Teresa
PY - 2014/10/9
Y1 - 2014/10/9
N2 - Aim
To determine the clinical significance of incidental hypermetabolic foci in the breast in patients who have undergone PET/CT for non breast malignancies.
Materials and Methods
We retrospectively reviewed the reports of 3000 PET/CT studies performed in women from January 2010 to April 2013. In those patients where incidental breast uptake was reported, the PET/CT was visually re-assessed and semiquantative analysis was performed by measuring the standardised uptake value (SUVmax) of the lesion as well as the liver (background). A ratio of lesion/liver SUVmax was then calculated.
Results
Incidental breast uptake was noted in n=32, hence 1%. Histology was available for n=17. 11/17 (65%) were found to be malignant with a mean SUV max of 5.1 and 6/17 (35%) were benign with a mean SUVmax of 1.8. This represents a statistically significant difference on unpaired t test (p <0.01.) The SUVmax/liver ratio in the benign lesions was 0.77 and for malignant lesions was 1.85 (p <0.01 . If a SUV cutoff of 2.3 is used, then all malignant lesions are detected
ConclusionIncidental hypermetabolic foci have a low incidence of 1%. However, 65% of these have malignant aetiology. Foci with a SUV>2.3 require follow up as are likely to represent occult malignancy.
AB - Aim
To determine the clinical significance of incidental hypermetabolic foci in the breast in patients who have undergone PET/CT for non breast malignancies.
Materials and Methods
We retrospectively reviewed the reports of 3000 PET/CT studies performed in women from January 2010 to April 2013. In those patients where incidental breast uptake was reported, the PET/CT was visually re-assessed and semiquantative analysis was performed by measuring the standardised uptake value (SUVmax) of the lesion as well as the liver (background). A ratio of lesion/liver SUVmax was then calculated.
Results
Incidental breast uptake was noted in n=32, hence 1%. Histology was available for n=17. 11/17 (65%) were found to be malignant with a mean SUV max of 5.1 and 6/17 (35%) were benign with a mean SUVmax of 1.8. This represents a statistically significant difference on unpaired t test (p <0.01.) The SUVmax/liver ratio in the benign lesions was 0.77 and for malignant lesions was 1.85 (p <0.01 . If a SUV cutoff of 2.3 is used, then all malignant lesions are detected
ConclusionIncidental hypermetabolic foci have a low incidence of 1%. However, 65% of these have malignant aetiology. Foci with a SUV>2.3 require follow up as are likely to represent occult malignancy.
U2 - 10.1007/s00259-014-2901-9
DO - 10.1007/s00259-014-2901-9
M3 - Meeting abstract
SN - 1619-7070
VL - 41
SP - S466
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
IS - Suppl 2
M1 - P375
ER -