Clinical significance of incidental finding of focal activity in the breast on 18F-FDG PET/CT scan

Richa Sinha, Tamara Suaris, James O'Doherty, Teresa Szyszko

Research output: Contribution to journalMeeting abstractpeer-review

Abstract

Aim To determine the clinical significance of incidental hypermetabolic foci in the breast in patients who have undergone PET/CT for non breast malignancies. Materials and Methods We retrospectively reviewed the reports of 3000 PET/CT studies performed in women from January 2010 to April 2013. In those patients where incidental breast uptake was reported, the PET/CT was visually re-assessed and semiquantative analysis was performed by measuring the standardised uptake value (SUVmax) of the lesion as well as the liver (background). A ratio of lesion/liver SUVmax was then calculated. Results Incidental breast uptake was noted in n=32, hence 1%. Histology was available for n=17. 11/17 (65%) were found to be malignant with a mean SUV max of 5.1 and 6/17 (35%) were benign with a mean SUVmax of 1.8. This represents a statistically significant difference on unpaired t test (p <0.01.) The SUVmax/liver ratio in the benign lesions was 0.77 and for malignant lesions was 1.85 (p <0.01 . If a SUV cutoff of 2.3 is used, then all malignant lesions are detected ConclusionIncidental hypermetabolic foci have a low incidence of 1%. However, 65% of these have malignant aetiology. Foci with a SUV>2.3 require follow up as are likely to represent occult malignancy.
Original languageEnglish
Article numberP375
Pages (from-to)S466
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume41
Issue numberSuppl 2
DOIs
Publication statusPublished - 9 Oct 2014

Fingerprint

Dive into the research topics of 'Clinical significance of incidental finding of focal activity in the breast on 18F-FDG PET/CT scan'. Together they form a unique fingerprint.

Cite this