Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers

Oliver Gale-Grant; Andrew Chew; Shona Falconer; Lucas França; Sunniva Fenn-Moltu; Laila Hadaya; Nicholas  Harper; Judit Ciarrusta Monzon; Tony Charman; Declan Murphy; Tomoki Arichi; Grainne McAlonan; Chiara Nosarti; David Edwards; Dafnis Batalle

doi:10.1038/s41598-024-58907-w

Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers

Oliver Gale-Grant, Andrew Chew, Shona Falconer, Lucas França, Sunniva Fenn-Moltu, Laila Hadaya, Nicholas Harper, Judit Ciarrusta Monzon, Tony Charman, Declan Murphy, Tomoki Arichi, Grainne McAlonan, Chiara Nosarti, David Edwards, Dafnis Batalle

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Abstract

Identifying factors linked to autism traits in the general population may improve our understanding of the mechanisms underlying divergent neurodevelopment. In this study we assess whether factors increasing the likelihood of childhood autism are related to early autistic trait emergence, or if other exposures are more important. We used data from 536 toddlers from London (UK), collected at birth (gestational age at birth, sex, maternal body mass index, age, parental education, parental language, parental history of neurodevelopmental conditions) and at 18 months (parents cohabiting, measures of socio-economic deprivation, measures of maternal parenting style, and a measure of maternal depression). Autism traits were assessed using the Quantitative Checklist for Autism in Toddlers (Q-CHAT) at 18 months. A multivariable model explained 20% of Q-CHAT variance, with four individually significant variables (two measures of parenting style and two measures of socio-economic deprivation). In order to address variable collinearity we used principal component analysis, finding that a component which was positively correlated with Q-CHAT was also correlated to measures of parenting style and socio-economic deprivation. Our results show that parenting style and socio-economic deprivation correlate with the emergence of autism traits at age 18 months as measured with the Q-CHAT in a community sample.

Original language	English
Article number	8393
Journal	Scientific Reports
Volume	14
Issue number	1
Early online date	10 Apr 2024
DOIs	https://doi.org/10.1038/s41598-024-58907-w
Publication status	Published - Dec 2024

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2024_04_GaleGrantEtAl_AcceptedAccepted author manuscript, 523 KBLicence: CC BY
2024_02_GaleGrant_ScientificReportsFinal published version, 1.08 MBLicence: CC BY

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Gale-Grant, O., Chew, A., Falconer, S., França, L., Fenn-Moltu, S., Hadaya, L., Harper, N., Ciarrusta Monzon, J., Charman, T., Murphy, D., Arichi, T., McAlonan, G., Nosarti, C., Edwards, D., & Batalle, D. (2024). Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers. Scientific Reports, 14(1), Article 8393. https://doi.org/10.1038/s41598-024-58907-w

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title = "Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers",

abstract = "Identifying factors linked to autism traits in the general population may improve our understanding of the mechanisms underlying divergent neurodevelopment. In this study we assess whether factors increasing the likelihood of childhood autism are related to early autistic trait emergence, or if other exposures are more important. We used data from 536 toddlers from London (UK), collected at birth (gestational age at birth, sex, maternal body mass index, age, parental education, parental language, parental history of neurodevelopmental conditions) and at 18 months (parents cohabiting, measures of socio-economic deprivation, measures of maternal parenting style, and a measure of maternal depression). Autism traits were assessed using the Quantitative Checklist for Autism in Toddlers (Q-CHAT) at 18 months. A multivariable model explained 20% of Q-CHAT variance, with four individually significant variables (two measures of parenting style and two measures of socio-economic deprivation). In order to address variable collinearity we used principal component analysis, finding that a component which was positively correlated with Q-CHAT was also correlated to measures of parenting style and socio-economic deprivation. Our results show that parenting style and socio-economic deprivation correlate with the emergence of autism traits at age 18 months as measured with the Q-CHAT in a community sample.",

author = "Oliver Gale-Grant and Andrew Chew and Shona Falconer and Lucas Fran{\c c}a and Sunniva Fenn-Moltu and Laila Hadaya and Nicholas Harper and {Ciarrusta Monzon}, Judit and Tony Charman and Declan Murphy and Tomoki Arichi and Grainne McAlonan and Chiara Nosarti and David Edwards and Dafnis Batalle",

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Gale-Grant, O , Chew, A , Falconer, S , França, L , Fenn-Moltu, S , Hadaya, L, Harper, N, Ciarrusta Monzon, J , Charman, T , Murphy, D , Arichi, T , McAlonan, G , Nosarti, C , Edwards, D & Batalle, D 2024, 'Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers', Scientific Reports, vol. 14, no. 1, 8393. https://doi.org/10.1038/s41598-024-58907-w

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T1 - Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers

AU - Gale-Grant, Oliver

AU - Chew, Andrew

AU - Falconer, Shona

AU - França, Lucas

AU - Fenn-Moltu, Sunniva

AU - Hadaya, Laila

AU - Harper, Nicholas

AU - Ciarrusta Monzon, Judit

AU - Charman, Tony

AU - Murphy, Declan

AU - Arichi, Tomoki

AU - McAlonan, Grainne

AU - Nosarti, Chiara

AU - Edwards, David

AU - Batalle, Dafnis

PY - 2024/12

Y1 - 2024/12

N2 - Identifying factors linked to autism traits in the general population may improve our understanding of the mechanisms underlying divergent neurodevelopment. In this study we assess whether factors increasing the likelihood of childhood autism are related to early autistic trait emergence, or if other exposures are more important. We used data from 536 toddlers from London (UK), collected at birth (gestational age at birth, sex, maternal body mass index, age, parental education, parental language, parental history of neurodevelopmental conditions) and at 18 months (parents cohabiting, measures of socio-economic deprivation, measures of maternal parenting style, and a measure of maternal depression). Autism traits were assessed using the Quantitative Checklist for Autism in Toddlers (Q-CHAT) at 18 months. A multivariable model explained 20% of Q-CHAT variance, with four individually significant variables (two measures of parenting style and two measures of socio-economic deprivation). In order to address variable collinearity we used principal component analysis, finding that a component which was positively correlated with Q-CHAT was also correlated to measures of parenting style and socio-economic deprivation. Our results show that parenting style and socio-economic deprivation correlate with the emergence of autism traits at age 18 months as measured with the Q-CHAT in a community sample.

AB - Identifying factors linked to autism traits in the general population may improve our understanding of the mechanisms underlying divergent neurodevelopment. In this study we assess whether factors increasing the likelihood of childhood autism are related to early autistic trait emergence, or if other exposures are more important. We used data from 536 toddlers from London (UK), collected at birth (gestational age at birth, sex, maternal body mass index, age, parental education, parental language, parental history of neurodevelopmental conditions) and at 18 months (parents cohabiting, measures of socio-economic deprivation, measures of maternal parenting style, and a measure of maternal depression). Autism traits were assessed using the Quantitative Checklist for Autism in Toddlers (Q-CHAT) at 18 months. A multivariable model explained 20% of Q-CHAT variance, with four individually significant variables (two measures of parenting style and two measures of socio-economic deprivation). In order to address variable collinearity we used principal component analysis, finding that a component which was positively correlated with Q-CHAT was also correlated to measures of parenting style and socio-economic deprivation. Our results show that parenting style and socio-economic deprivation correlate with the emergence of autism traits at age 18 months as measured with the Q-CHAT in a community sample.

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VL - 14

JO - Scientific Reports

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ER -

Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers

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