Clinical trial to compare efficacy and side-effects of injection of posterior sub-Tenon triamcinolone versus orbital floor methylprednisolone in the management of posterior uveitis

Paolo Ferrante, Andrew Ramsey, Catey Bunce, Susan Lightman

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83 Citations (Scopus)

Abstract

AIM: To compare the efficacy and side-effects of posterior sub-Tenon injection of triamcinolone acetonide (Kenalog) with orbital floor injection of methylpredisolone acetate (Depomedrone) in the management of posterior uveitis.

METHODS: Non-randomized comparative prospective clinical study. Sixty-four eyes from 60 consecutive patients with non-infectious posterior uveitis requiring treatment were allocated on an alternate 1:1 basis to receive either orbital floor methylprednisolone or sub-Tenon triamcinolone using standard procedures and assessed at 6 and 12 weeks.

RESULTS: After five eyes of five patients who had received the same treatment bilaterally were excluded from the statistical analysis, 14 out of 29 eyes treated with orbital floor methylprednisolone and 10 out of the 30 eyes given sub-Tenon triamcinolone improved at 6 weeks. There was no statistically significant difference in the improvement rate between the two groups. However, two patients given triamcinolone had prolonged upper lid ptosis, which required surgery, and another two developed markedly raised intraocular pressure, neither of which occurred in the methylprednisolone-treated group.

CONCLUSIONS: Although the two drugs and routes compared were of similar efficacy, lid ptosis occurred in the triamcinolone-treated but not the methylprednisolone group. This should be borne in mind when choosing the preferred route of delivery of periocular corticosteroid in the treatment of posterior uveitis.

Original languageEnglish
Pages (from-to)563-8
Number of pages6
JournalCLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Volume32
Issue number6
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Blepharoptosis
  • Connective Tissue
  • Drug Administration Routes
  • Glucocorticoids
  • Humans
  • Injections
  • Intraocular Pressure
  • Methylprednisolone
  • Orbit
  • Prospective Studies
  • Safety
  • Treatment Outcome
  • Triamcinolone Acetonide
  • Uveitis, Posterior
  • Visual Acuity
  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Journal Article

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