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Clinical Trials on Management of Pain in Parkinson’s Disease

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Azman Aris, Katarina Rukavina, Raquel Taddei, Alexandra Rizos, Anna Sauerbier, K. Ray Chaudhuri

Original languageEnglish
Title of host publicationNeuromethods
PublisherHumana Press Inc
Pages293-321
Number of pages29
DOIs
Published1 Jan 2021

Publication series

NameNeuromethods
Volume160
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

King's Authors

Abstract

Pain is highly prevalent in Parkinson’s disease (PD). It is one of the most common nonmotor symptoms of PD, and it may precede motor symptoms by several years. There are various types of pain described in PD, reflecting its heterogeneity and multifactorial origin. Pain in PD has been reported to differ between gender, early and advanced stages of PD, motor and nonmotor subtypes, and to fluctuate during on and off states. For the management of pain, it is crucial to separate PD-related pain from pain of other origins. Pain has a negative impact on the overall quality of life in PD patients. Early recognition and holistic assessment of pain are therefore important for personalized medicine delivery. When conducting a clinical trial in pain, study methodology and design need to be tailored to the multifaceted features of PD pain. The used assessment tools ideally have to be specific and sensitive to these features. In this book chapter, we discuss and outline the evaluation of PD-related pain, review PD general and specific pain assessment tools, and discuss relevant clinical trials addressing treatment of pain in PD.

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