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Clinical use of tolerogenic dendritic cells-harmonization approach in european collaborative effort

Research output: Contribution to journalArticle

Anja Ten Brinke, Catharien M U Hilkens, Nathalie Cools, Edward K. Geissler, James A. Hutchinson, Giovanna Lombardi, Phillip Lord, Birgit Sawitzki, Piotr Trzonkowski, S. Marieke Van Ham, Eva M. Martinez-Caceres

Original languageEnglish
Article number471719
JournalMEDIATORS OF INFLAMMATION
Volume2015
DOIs
Accepted/In press6 Dec 2015
Published2015

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  • 471719

    471719.pdf, 1.38 MB, application/pdf

    Uploaded date:18 Mar 2016

    Version:Final published version

    Licence:CC BY

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Abstract

The number of patients with autoimmune diseases and severe allergies and recipients of transplants increases worldwide. Currently, these patients require lifelong administration of immunomodulatory drugs. Often, these drugs are expensive and show immediate or late-occurring severe side effects. Treatment would be greatly improved by targeting the cause of autoimmunity, that is, loss of tolerance to self-antigens. Accumulating knowledge on immune mechanisms has led to the development of tolerogenic dendritic cells (tolDC), with the specific objective to restrain unwanted immune reactions in the long term. The first clinical trials with tolDC have recently been conducted and more tolDC trials are underway. Although the safety trials have been encouraging, many questions relating to tolDC, for example, cell-manufacturing protocols, administration route, amount and frequency, or mechanism of action, remain to be answered. Aiming to join efforts in translating tolDC and other tolerogenic cellular products (e.g., Tregs and macrophages) to the clinic, a European COST (European Cooperation in Science and Technology) network has been initiated - A FACTT (action to focus and accelerate cell-based tolerance-inducing therapies). A FACTT aims to minimize overlap and maximize comparison of tolDC approaches through establishment of minimum information models and consensus monitoring parameters, ensuring that progress will be in an efficient, safe, and cost-effective way.

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