Clinical utilization of Chimeric Antigen Receptors T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) – an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT)

Ankit J. Kansagra; Noelle V. Frey; Merav Bar; Theodore W. Laetsch; Paul A. Carpenter; Bipin N. Savani; Helen E. Heslop; Catherine M. Bollard; Krishna V. Komanduri; Dennis A. Gastineau; Christian Chabannon; Miguel A. Perales; Michael Hudecek; Mahmoud Aljurf; Leslie Andritsos; John A. Barrett; Veronika Bachanova; Chiara Bonini; Armin Ghobadi; Saar I. Gill; Joshua Hill; Saad Kenderian; Partow Kebriaei; Arnon Nagler; David Maloney; Hien D. Liu; Nirali N. Shah; Mohamed A. Kharfan-Dabaja; Elizabeth J Shpall; Ghulam J. Mufti; Laura Johnston; Elad Jacoby; Ali Bazarbachi; John F. DiPersio; Steven Z. Pavletic; David L. Porter; Stephan A Grupp; Michel Sadelain; Mark R. Litzow; Mohamad Mohty; Shahrukh K. Hashmi

doi:10.1016/j.bbmt.2018.12.068

Clinical utilization of Chimeric Antigen Receptors T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) – an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT)

Ankit J. Kansagra, Noelle V. Frey, Merav Bar, Theodore W. Laetsch, Paul A. Carpenter, Bipin N. Savani, Helen E. Heslop, Catherine M. Bollard, Krishna V. Komanduri, Dennis A. Gastineau, Christian Chabannon, Miguel A. Perales, Michael Hudecek, Mahmoud Aljurf, Leslie Andritsos, John A. Barrett, Veronika Bachanova, Chiara Bonini, Armin Ghobadi, Saar I. GillJoshua Hill, Saad Kenderian, Partow Kebriaei, Arnon Nagler, David Maloney, Hien D. Liu, Nirali N. Shah, Mohamed A. Kharfan-Dabaja, Elizabeth J Shpall, Ghulam J. Mufti, Laura Johnston, Elad Jacoby, Ali Bazarbachi, John F. DiPersio, Steven Z. Pavletic, David L. Porter, Stephan A Grupp, Michel Sadelain, Mark R. Litzow, Mohamad Mohty, Shahrukh K. Hashmi

Research output: Contribution to journal › Article › peer-review

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Abstract

On August 30, 2017, the U.S. Food and Drug Administration (US-FDA) approved tisagenlecleucel (KYMRIAH, Novartis, Basel, Switzerland), a synthetic bioimmune product of anti-CD19 chimeric antigen receptor - T cells (CAR-T), for the treatment of children and young adults with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). With this new era of personalized cancer immunotherapy, multiple challenges are present ranging from implementation of a CAR-T program to safe delivery of the drug, long-term toxicity monitoring and disease assessments. To address these issues, experts representing the American Society for Blood and Marrow Transplant (ASBMT), the European Group for Blood and Marrow Transplantation (EBMT), the International Society of Cell and Gene Therapy (ISCT), and the Foundation for the Accreditation of Cellular Therapy (FACT), formed a global CAR-T task force to identify and address key questions pertinent for hematologists and transplant physicians regarding the clinical use of anti CD19 CAR-T therapy in patients with B-ALL. This article presents an initial roadmap for navigating common clinical practice scenarios that will become more prevalent now that the first commercially available CAR-T product for B-ALL has been approved.

Original language	English
Journal	BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Early online date	18 Dec 2018
DOIs	https://doi.org/10.1016/j.bbmt.2018.12.068
Publication status	E-pub ahead of print - 18 Dec 2018

Keywords

Chimeric antigen receptor
T-cell
Leukemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Kansagra, A. J., Frey, N. V., Bar, M., Laetsch, T. W., Carpenter, P. A., Savani, B. N., Heslop, H. E., Bollard, C. M., Komanduri, K. V., Gastineau, D. A., Chabannon, C., Perales, M. A., Hudecek, M., Aljurf, M., Andritsos, L., Barrett, J. A., Bachanova, V., Bonini, C., Ghobadi, A., ... Hashmi, S. K. (2018). Clinical utilization of Chimeric Antigen Receptors T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) – an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT). BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. Advance online publication. https://doi.org/10.1016/j.bbmt.2018.12.068

Kansagra, Ankit J. ; Frey, Noelle V. ; Bar, Merav et al. / Clinical utilization of Chimeric Antigen Receptors T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) – an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT). In: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. 2018.

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title = "Clinical utilization of Chimeric Antigen Receptors T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) – an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT)",

abstract = "On August 30, 2017, the U.S. Food and Drug Administration (US-FDA) approved tisagenlecleucel (KYMRIAH, Novartis, Basel, Switzerland), a synthetic bioimmune product of anti-CD19 chimeric antigen receptor - T cells (CAR-T), for the treatment of children and young adults with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). With this new era of personalized cancer immunotherapy, multiple challenges are present ranging from implementation of a CAR-T program to safe delivery of the drug, long-term toxicity monitoring and disease assessments. To address these issues, experts representing the American Society for Blood and Marrow Transplant (ASBMT), the European Group for Blood and Marrow Transplantation (EBMT), the International Society of Cell and Gene Therapy (ISCT), and the Foundation for the Accreditation of Cellular Therapy (FACT), formed a global CAR-T task force to identify and address key questions pertinent for hematologists and transplant physicians regarding the clinical use of anti CD19 CAR-T therapy in patients with B-ALL. This article presents an initial roadmap for navigating common clinical practice scenarios that will become more prevalent now that the first commercially available CAR-T product for B-ALL has been approved.",

keywords = "Chimeric antigen receptor, T-cell, Leukemia",

author = "Kansagra, {Ankit J.} and Frey, {Noelle V.} and Merav Bar and Laetsch, {Theodore W.} and Carpenter, {Paul A.} and Savani, {Bipin N.} and Heslop, {Helen E.} and Bollard, {Catherine M.} and Komanduri, {Krishna V.} and Gastineau, {Dennis A.} and Christian Chabannon and Perales, {Miguel A.} and Michael Hudecek and Mahmoud Aljurf and Leslie Andritsos and Barrett, {John A.} and Veronika Bachanova and Chiara Bonini and Armin Ghobadi and Gill, {Saar I.} and Joshua Hill and Saad Kenderian and Partow Kebriaei and Arnon Nagler and David Maloney and Liu, {Hien D.} and Shah, {Nirali N.} and Kharfan-Dabaja, {Mohamed A.} and Shpall, {Elizabeth J} and Mufti, {Ghulam J.} and Laura Johnston and Elad Jacoby and Ali Bazarbachi and DiPersio, {John F.} and Pavletic, {Steven Z.} and Porter, {David L.} and Grupp, {Stephan A} and Michel Sadelain and Litzow, {Mark R.} and Mohamad Mohty and Hashmi, {Shahrukh K.}",

year = "2018",

month = dec,

day = "18",

doi = "10.1016/j.bbmt.2018.12.068",

language = "English",

journal = "BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION",

issn = "1083-8791",

publisher = "Elsevier Inc.",

}

Kansagra, AJ, Frey, NV, Bar, M, Laetsch, TW, Carpenter, PA, Savani, BN, Heslop, HE, Bollard, CM, Komanduri, KV, Gastineau, DA, Chabannon, C, Perales, MA, Hudecek, M, Aljurf, M, Andritsos, L, Barrett, JA, Bachanova, V, Bonini, C, Ghobadi, A, Gill, SI, Hill, J, Kenderian, S, Kebriaei, P, Nagler, A, Maloney, D, Liu, HD, Shah, NN, Kharfan-Dabaja, MA, Shpall, EJ, Mufti, GJ, Johnston, L, Jacoby, E, Bazarbachi, A, DiPersio, JF, Pavletic, SZ, Porter, DL, Grupp, SA, Sadelain, M, Litzow, MR, Mohty, M & Hashmi, SK 2018, 'Clinical utilization of Chimeric Antigen Receptors T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) – an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT)', BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. https://doi.org/10.1016/j.bbmt.2018.12.068

Clinical utilization of Chimeric Antigen Receptors T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) – an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT). / Kansagra, Ankit J.; Frey, Noelle V.; Bar, Merav et al.
In: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 18.12.2018.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clinical utilization of Chimeric Antigen Receptors T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) – an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT)

AU - Kansagra, Ankit J.

AU - Frey, Noelle V.

AU - Bar, Merav

AU - Laetsch, Theodore W.

AU - Carpenter, Paul A.

AU - Savani, Bipin N.

AU - Heslop, Helen E.

AU - Bollard, Catherine M.

AU - Komanduri, Krishna V.

AU - Gastineau, Dennis A.

AU - Chabannon, Christian

AU - Perales, Miguel A.

AU - Hudecek, Michael

AU - Aljurf, Mahmoud

AU - Andritsos, Leslie

AU - Barrett, John A.

AU - Bachanova, Veronika

AU - Bonini, Chiara

AU - Ghobadi, Armin

AU - Gill, Saar I.

AU - Hill, Joshua

AU - Kenderian, Saad

AU - Kebriaei, Partow

AU - Nagler, Arnon

AU - Maloney, David

AU - Liu, Hien D.

AU - Shah, Nirali N.

AU - Kharfan-Dabaja, Mohamed A.

AU - Shpall, Elizabeth J

AU - Mufti, Ghulam J.

AU - Johnston, Laura

AU - Jacoby, Elad

AU - Bazarbachi, Ali

AU - DiPersio, John F.

AU - Pavletic, Steven Z.

AU - Porter, David L.

AU - Grupp, Stephan A

AU - Sadelain, Michel

AU - Litzow, Mark R.

AU - Mohty, Mohamad

AU - Hashmi, Shahrukh K.

PY - 2018/12/18

Y1 - 2018/12/18

N2 - On August 30, 2017, the U.S. Food and Drug Administration (US-FDA) approved tisagenlecleucel (KYMRIAH, Novartis, Basel, Switzerland), a synthetic bioimmune product of anti-CD19 chimeric antigen receptor - T cells (CAR-T), for the treatment of children and young adults with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). With this new era of personalized cancer immunotherapy, multiple challenges are present ranging from implementation of a CAR-T program to safe delivery of the drug, long-term toxicity monitoring and disease assessments. To address these issues, experts representing the American Society for Blood and Marrow Transplant (ASBMT), the European Group for Blood and Marrow Transplantation (EBMT), the International Society of Cell and Gene Therapy (ISCT), and the Foundation for the Accreditation of Cellular Therapy (FACT), formed a global CAR-T task force to identify and address key questions pertinent for hematologists and transplant physicians regarding the clinical use of anti CD19 CAR-T therapy in patients with B-ALL. This article presents an initial roadmap for navigating common clinical practice scenarios that will become more prevalent now that the first commercially available CAR-T product for B-ALL has been approved.

AB - On August 30, 2017, the U.S. Food and Drug Administration (US-FDA) approved tisagenlecleucel (KYMRIAH, Novartis, Basel, Switzerland), a synthetic bioimmune product of anti-CD19 chimeric antigen receptor - T cells (CAR-T), for the treatment of children and young adults with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). With this new era of personalized cancer immunotherapy, multiple challenges are present ranging from implementation of a CAR-T program to safe delivery of the drug, long-term toxicity monitoring and disease assessments. To address these issues, experts representing the American Society for Blood and Marrow Transplant (ASBMT), the European Group for Blood and Marrow Transplantation (EBMT), the International Society of Cell and Gene Therapy (ISCT), and the Foundation for the Accreditation of Cellular Therapy (FACT), formed a global CAR-T task force to identify and address key questions pertinent for hematologists and transplant physicians regarding the clinical use of anti CD19 CAR-T therapy in patients with B-ALL. This article presents an initial roadmap for navigating common clinical practice scenarios that will become more prevalent now that the first commercially available CAR-T product for B-ALL has been approved.

KW - Chimeric antigen receptor

KW - T-cell

KW - Leukemia

U2 - 10.1016/j.bbmt.2018.12.068

DO - 10.1016/j.bbmt.2018.12.068

M3 - Article

SN - 1083-8791

JO - BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

JF - BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

ER -

Kansagra AJ, Frey NV, Bar M, Laetsch TW, Carpenter PA, Savani BN et al. Clinical utilization of Chimeric Antigen Receptors T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) – an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT). BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. 2018 Dec 18. Epub 2018 Dec 18. doi: 10.1016/j.bbmt.2018.12.068