Clinically driven design of multi-scale cancer models: the ContraCancrum project paradigm

K Marias; Dionysia Dionysiou; V Sakkalis; N Graf; R M Bohle; P V Coveney; S Wan; A Folarin; P Büchler; M Reyes; G Clapworthy; E Liu; J Sabczynski; T Bily; A Roniotis; M Tsiknakis; E Kolokotroni; S Giatili; C Veith; E Messe; H Stenzhorn; Yoo-Jin Kim; S Zasada; A N Haidar; Caroline May; S Bauer; T Wang; Y Zhao; M Karasek; R Grewer; A Franz; G Stamatakos

doi:10.1098/rsfs.2010.0037

Clinically driven design of multi-scale cancer models: the ContraCancrum project paradigm

K Marias, Dionysia Dionysiou, V Sakkalis, N Graf, R M Bohle, P V Coveney, S Wan, A Folarin, P Büchler, M Reyes, G Clapworthy, E Liu, J Sabczynski, T Bily, A Roniotis, M Tsiknakis, E Kolokotroni, S Giatili, C Veith, E MesseH Stenzhorn, Yoo-Jin Kim, S Zasada, A N Haidar, Caroline May, S Bauer, T Wang, Y Zhao, M Karasek, R Grewer, A Franz, G Stamatakos

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Abstract

The challenge of modelling cancer presents a major opportunity to improve our ability to reduce mortality from malignant neoplasms, improve treatments and meet the demands associated with the individualization of care needs. This is the central motivation behind the ContraCancrum project. By developing integrated multi-scale cancer models, ContraCancrum is expected to contribute to the advancement of in silico oncology through the optimization of cancer treatment in the patient-individualized context by simulating the response to various therapeutic regimens. The aim of the present paper is to describe a novel paradigm for designing clinically driven multi-scale cancer modelling by bringing together basic science and information technology modules. In addition, the integration of the multi-scale tumour modelling components has led to novel concepts of personalized clinical decision support in the context of predictive oncology, as is also discussed in the paper. Since clinical adaptation is an inelastic prerequisite, a long-term clinical adaptation procedure of the models has been initiated for two tumour types, namely non-small cell lung cancer and glioblastoma multiforme; its current status is briefly summarized.

Original language	English
Pages (from-to)	450-461
Number of pages	12
Journal	Interface Focus
Volume	1
Issue number	3
DOIs	https://doi.org/10.1098/rsfs.2010.0037
Publication status	Published - 6 Jun 2011

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Marias, K., Dionysiou, D., Sakkalis, V., Graf, N., Bohle, R. M., Coveney, P. V., Wan, S., Folarin, A., Büchler, P., Reyes, M., Clapworthy, G., Liu, E., Sabczynski, J., Bily, T., Roniotis, A., Tsiknakis, M., Kolokotroni, E., Giatili, S., Veith, C., ... Stamatakos, G. (2011). Clinically driven design of multi-scale cancer models: the ContraCancrum project paradigm. Interface Focus, 1(3), 450-461. https://doi.org/10.1098/rsfs.2010.0037

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title = "Clinically driven design of multi-scale cancer models: the ContraCancrum project paradigm",

abstract = "The challenge of modelling cancer presents a major opportunity to improve our ability to reduce mortality from malignant neoplasms, improve treatments and meet the demands associated with the individualization of care needs. This is the central motivation behind the ContraCancrum project. By developing integrated multi-scale cancer models, ContraCancrum is expected to contribute to the advancement of in silico oncology through the optimization of cancer treatment in the patient-individualized context by simulating the response to various therapeutic regimens. The aim of the present paper is to describe a novel paradigm for designing clinically driven multi-scale cancer modelling by bringing together basic science and information technology modules. In addition, the integration of the multi-scale tumour modelling components has led to novel concepts of personalized clinical decision support in the context of predictive oncology, as is also discussed in the paper. Since clinical adaptation is an inelastic prerequisite, a long-term clinical adaptation procedure of the models has been initiated for two tumour types, namely non-small cell lung cancer and glioblastoma multiforme; its current status is briefly summarized.",

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year = "2011",

month = jun,

day = "6",

doi = "10.1098/rsfs.2010.0037",

language = "English",

volume = "1",

pages = "450--461",

journal = "Interface Focus",

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Marias, K, Dionysiou, D, Sakkalis, V, Graf, N, Bohle, RM, Coveney, PV, Wan, S, Folarin, A, Büchler, P, Reyes, M, Clapworthy, G, Liu, E, Sabczynski, J, Bily, T, Roniotis, A, Tsiknakis, M, Kolokotroni, E, Giatili, S, Veith, C, Messe, E, Stenzhorn, H, Kim, Y-J, Zasada, S, Haidar, AN, May, C, Bauer, S, Wang, T, Zhao, Y, Karasek, M, Grewer, R, Franz, A & Stamatakos, G 2011, 'Clinically driven design of multi-scale cancer models: the ContraCancrum project paradigm', Interface Focus, vol. 1, no. 3, pp. 450-461. https://doi.org/10.1098/rsfs.2010.0037

TY - JOUR

T1 - Clinically driven design of multi-scale cancer models

T2 - the ContraCancrum project paradigm

AU - Marias, K

AU - Dionysiou, Dionysia

AU - Sakkalis, V

AU - Graf, N

AU - Bohle, R M

AU - Coveney, P V

AU - Wan, S

AU - Folarin, A

AU - Büchler, P

AU - Reyes, M

AU - Clapworthy, G

AU - Liu, E

AU - Sabczynski, J

AU - Bily, T

AU - Roniotis, A

AU - Tsiknakis, M

AU - Kolokotroni, E

AU - Giatili, S

AU - Veith, C

AU - Messe, E

AU - Stenzhorn, H

AU - Kim, Yoo-Jin

AU - Zasada, S

AU - Haidar, A N

AU - May, Caroline

AU - Bauer, S

AU - Wang, T

AU - Zhao, Y

AU - Karasek, M

AU - Grewer, R

AU - Franz, A

AU - Stamatakos, G

PY - 2011/6/6

Y1 - 2011/6/6

N2 - The challenge of modelling cancer presents a major opportunity to improve our ability to reduce mortality from malignant neoplasms, improve treatments and meet the demands associated with the individualization of care needs. This is the central motivation behind the ContraCancrum project. By developing integrated multi-scale cancer models, ContraCancrum is expected to contribute to the advancement of in silico oncology through the optimization of cancer treatment in the patient-individualized context by simulating the response to various therapeutic regimens. The aim of the present paper is to describe a novel paradigm for designing clinically driven multi-scale cancer modelling by bringing together basic science and information technology modules. In addition, the integration of the multi-scale tumour modelling components has led to novel concepts of personalized clinical decision support in the context of predictive oncology, as is also discussed in the paper. Since clinical adaptation is an inelastic prerequisite, a long-term clinical adaptation procedure of the models has been initiated for two tumour types, namely non-small cell lung cancer and glioblastoma multiforme; its current status is briefly summarized.

AB - The challenge of modelling cancer presents a major opportunity to improve our ability to reduce mortality from malignant neoplasms, improve treatments and meet the demands associated with the individualization of care needs. This is the central motivation behind the ContraCancrum project. By developing integrated multi-scale cancer models, ContraCancrum is expected to contribute to the advancement of in silico oncology through the optimization of cancer treatment in the patient-individualized context by simulating the response to various therapeutic regimens. The aim of the present paper is to describe a novel paradigm for designing clinically driven multi-scale cancer modelling by bringing together basic science and information technology modules. In addition, the integration of the multi-scale tumour modelling components has led to novel concepts of personalized clinical decision support in the context of predictive oncology, as is also discussed in the paper. Since clinical adaptation is an inelastic prerequisite, a long-term clinical adaptation procedure of the models has been initiated for two tumour types, namely non-small cell lung cancer and glioblastoma multiforme; its current status is briefly summarized.

U2 - 10.1098/rsfs.2010.0037

DO - 10.1098/rsfs.2010.0037

M3 - Article

C2 - 22670213

SN - 2042-8898

VL - 1

SP - 450

EP - 461

JO - Interface Focus

JF - Interface Focus

IS - 3

ER -

Clinically driven design of multi-scale cancer models: the ContraCancrum project paradigm

Abstract

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