Clinically Significant Peripancreatic Fluid Collections After Simultaneous Pancreas-Kidney Transplantation

Rajinder Pal Singh; Georgios Vrakas; Samiha Hayek; Sara Hayek; Sadia Anam; Mariam Aqueel; Jonathon Olsburgh; Francis Calder; Nizam Mamode; Chris Callaghan; Nicos Kessaris; James Pattison; Rachel Hilton; Geoff Koffman; John D. Taylor; Martin Drage

doi:10.1097/TP.0b013e318289c978

Clinically Significant Peripancreatic Fluid Collections After Simultaneous Pancreas-Kidney Transplantation

Rajinder Pal Singh^*, Georgios Vrakas, Samiha Hayek, Sara Hayek, Sadia Anam, Mariam Aqueel, Jonathon Olsburgh, Francis Calder, Nizam Mamode, Chris Callaghan, Nicos Kessaris, James Pattison, Rachel Hilton, Geoff Koffman, John D. Taylor, Martin Drage

^*Corresponding author for this work

GSTT Guy's and St Thomas' NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background. Peripancreatic fluid collections (PPFC) are a serious complication after simultaneous pancreas-kidney transplantation (SPKTx).

Methods. Retrospective study for all 223 SPKTx performed from December 8, 1996, to October 10, 2011, to evaluate the risk factors (RF) and impact of PPFCs on outcomes was conducted.

Results. Clinically significant PPFCs were seen in 36 (16%) cases, all within 3 months after transplantation. Radiologic drainage resolved 2 (6%) cases, and 34 required laparotomy (mean [SD], 4 [7]). Compared with the non-PPFC group (n=186), the PPFC group had similar patient and total kidney graft survivals but significantly lower total pancreas survival (68% vs. 85%) and greater incidence of infections (75% vs. 46%, all P30 and pancreas cold ischemia time greater than 12 hr.

Conclusions. PPFCs are associated with significant reduction in pancreas allograft survival and impact resource use. Donor age >30 years is a significant RF for their development. PPFCs associated with pancreatic fistula carry a greater risk for pancreas graft loss.

Original language	English
Pages (from-to)	1263-1269
Number of pages	7
Journal	Transplantation
Volume	95
Issue number	10
DOIs	https://doi.org/10.1097/TP.0b013e318289c978
Publication status	Published - 27 May 2013

Keywords

Pancreas
Transplantation
Complications
RISK-FACTORS
SURGICAL COMPLICATIONS
MULTIVARIATE-ANALYSIS
GRAFT PANCREATITIS
CARDIAC DEATH
DONATION
OUTCOMES
THROMBOSIS
RECIPIENTS
IMPACT

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10.1097/TP.0b013e318289c978

Cite this

Singh, R. P., Vrakas, G., Hayek, S., Hayek, S., Anam, S., Aqueel, M., Olsburgh, J., Calder, F., Mamode, N., Callaghan, C., Kessaris, N., Pattison, J., Hilton, R., Koffman, G., Taylor, J. D., & Drage, M. (2013). Clinically Significant Peripancreatic Fluid Collections After Simultaneous Pancreas-Kidney Transplantation. Transplantation, 95(10), 1263-1269. https://doi.org/10.1097/TP.0b013e318289c978

@article{89e70ef3b3a4414996842ff26d978ee0,

title = "Clinically Significant Peripancreatic Fluid Collections After Simultaneous Pancreas-Kidney Transplantation",

abstract = "Background. Peripancreatic fluid collections (PPFC) are a serious complication after simultaneous pancreas-kidney transplantation (SPKTx).Methods. Retrospective study for all 223 SPKTx performed from December 8, 1996, to October 10, 2011, to evaluate the risk factors (RF) and impact of PPFCs on outcomes was conducted.Results. Clinically significant PPFCs were seen in 36 (16%) cases, all within 3 months after transplantation. Radiologic drainage resolved 2 (6%) cases, and 34 required laparotomy (mean [SD], 4 [7]). Compared with the non-PPFC group (n=186), the PPFC group had similar patient and total kidney graft survivals but significantly lower total pancreas survival (68% vs. 85%) and greater incidence of infections (75% vs. 46%, all P30 and pancreas cold ischemia time greater than 12 hr.Conclusions. PPFCs are associated with significant reduction in pancreas allograft survival and impact resource use. Donor age >30 years is a significant RF for their development. PPFCs associated with pancreatic fistula carry a greater risk for pancreas graft loss.",

keywords = "Pancreas, Transplantation, Complications, RISK-FACTORS, SURGICAL COMPLICATIONS, MULTIVARIATE-ANALYSIS, GRAFT PANCREATITIS, CARDIAC DEATH, DONATION, OUTCOMES, THROMBOSIS, RECIPIENTS, IMPACT",

author = "Singh, {Rajinder Pal} and Georgios Vrakas and Samiha Hayek and Sara Hayek and Sadia Anam and Mariam Aqueel and Jonathon Olsburgh and Francis Calder and Nizam Mamode and Chris Callaghan and Nicos Kessaris and James Pattison and Rachel Hilton and Geoff Koffman and Taylor, {John D.} and Martin Drage",

year = "2013",

month = may,

day = "27",

doi = "10.1097/TP.0b013e318289c978",

language = "English",

volume = "95",

pages = "1263--1269",

journal = "Transplantation",

issn = "0041-1337",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

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Singh, RP, Vrakas, G, Hayek, S, Hayek, S, Anam, S, Aqueel, M, Olsburgh, J , Calder, F , Mamode, N , Callaghan, C , Kessaris, N , Pattison, J , Hilton, R , Koffman, G, Taylor, JD & Drage, M 2013, 'Clinically Significant Peripancreatic Fluid Collections After Simultaneous Pancreas-Kidney Transplantation', Transplantation, vol. 95, no. 10, pp. 1263-1269. https://doi.org/10.1097/TP.0b013e318289c978

TY - JOUR

T1 - Clinically Significant Peripancreatic Fluid Collections After Simultaneous Pancreas-Kidney Transplantation

AU - Singh, Rajinder Pal

AU - Vrakas, Georgios

AU - Hayek, Samiha

AU - Hayek, Sara

AU - Anam, Sadia

AU - Aqueel, Mariam

AU - Olsburgh, Jonathon

AU - Calder, Francis

AU - Mamode, Nizam

AU - Callaghan, Chris

AU - Kessaris, Nicos

AU - Pattison, James

AU - Hilton, Rachel

AU - Koffman, Geoff

AU - Taylor, John D.

AU - Drage, Martin

PY - 2013/5/27

Y1 - 2013/5/27

N2 - Background. Peripancreatic fluid collections (PPFC) are a serious complication after simultaneous pancreas-kidney transplantation (SPKTx).Methods. Retrospective study for all 223 SPKTx performed from December 8, 1996, to October 10, 2011, to evaluate the risk factors (RF) and impact of PPFCs on outcomes was conducted.Results. Clinically significant PPFCs were seen in 36 (16%) cases, all within 3 months after transplantation. Radiologic drainage resolved 2 (6%) cases, and 34 required laparotomy (mean [SD], 4 [7]). Compared with the non-PPFC group (n=186), the PPFC group had similar patient and total kidney graft survivals but significantly lower total pancreas survival (68% vs. 85%) and greater incidence of infections (75% vs. 46%, all P30 and pancreas cold ischemia time greater than 12 hr.Conclusions. PPFCs are associated with significant reduction in pancreas allograft survival and impact resource use. Donor age >30 years is a significant RF for their development. PPFCs associated with pancreatic fistula carry a greater risk for pancreas graft loss.

AB - Background. Peripancreatic fluid collections (PPFC) are a serious complication after simultaneous pancreas-kidney transplantation (SPKTx).Methods. Retrospective study for all 223 SPKTx performed from December 8, 1996, to October 10, 2011, to evaluate the risk factors (RF) and impact of PPFCs on outcomes was conducted.Results. Clinically significant PPFCs were seen in 36 (16%) cases, all within 3 months after transplantation. Radiologic drainage resolved 2 (6%) cases, and 34 required laparotomy (mean [SD], 4 [7]). Compared with the non-PPFC group (n=186), the PPFC group had similar patient and total kidney graft survivals but significantly lower total pancreas survival (68% vs. 85%) and greater incidence of infections (75% vs. 46%, all P30 and pancreas cold ischemia time greater than 12 hr.Conclusions. PPFCs are associated with significant reduction in pancreas allograft survival and impact resource use. Donor age >30 years is a significant RF for their development. PPFCs associated with pancreatic fistula carry a greater risk for pancreas graft loss.

KW - Pancreas

KW - Transplantation

KW - Complications

KW - RISK-FACTORS

KW - SURGICAL COMPLICATIONS

KW - MULTIVARIATE-ANALYSIS

KW - GRAFT PANCREATITIS

KW - CARDIAC DEATH

KW - DONATION

KW - OUTCOMES

KW - THROMBOSIS

KW - RECIPIENTS

KW - IMPACT

U2 - 10.1097/TP.0b013e318289c978

DO - 10.1097/TP.0b013e318289c978

M3 - Article

SN - 0041-1337

VL - 95

SP - 1263

EP - 1269

JO - Transplantation

JF - Transplantation

IS - 10

ER -

Clinically Significant Peripancreatic Fluid Collections After Simultaneous Pancreas-Kidney Transplantation

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Keywords

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