Clinically Significant Peripancreatic Fluid Collections After Simultaneous Pancreas-Kidney Transplantation

Rajinder Pal Singh*, Georgios Vrakas, Samiha Hayek, Sara Hayek, Sadia Anam, Mariam Aqueel, Jonathon Olsburgh, Francis Calder, Nizam Mamode, Chris Callaghan, Nicos Kessaris, James Pattison, Rachel Hilton, Geoff Koffman, John D. Taylor, Martin Drage

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)

    Abstract

    Background. Peripancreatic fluid collections (PPFC) are a serious complication after simultaneous pancreas-kidney transplantation (SPKTx).

    Methods. Retrospective study for all 223 SPKTx performed from December 8, 1996, to October 10, 2011, to evaluate the risk factors (RF) and impact of PPFCs on outcomes was conducted.

    Results. Clinically significant PPFCs were seen in 36 (16%) cases, all within 3 months after transplantation. Radiologic drainage resolved 2 (6%) cases, and 34 required laparotomy (mean [SD], 4 [7]). Compared with the non-PPFC group (n=186), the PPFC group had similar patient and total kidney graft survivals but significantly lower total pancreas survival (68% vs. 85%) and greater incidence of infections (75% vs. 46%, all P30 and pancreas cold ischemia time greater than 12 hr.

    Conclusions. PPFCs are associated with significant reduction in pancreas allograft survival and impact resource use. Donor age >30 years is a significant RF for their development. PPFCs associated with pancreatic fistula carry a greater risk for pancreas graft loss.

    Original languageEnglish
    Pages (from-to)1263-1269
    Number of pages7
    JournalTransplantation
    Volume95
    Issue number10
    DOIs
    Publication statusPublished - 27 May 2013

    Keywords

    • Pancreas
    • Transplantation
    • Complications
    • RISK-FACTORS
    • SURGICAL COMPLICATIONS
    • MULTIVARIATE-ANALYSIS
    • GRAFT PANCREATITIS
    • CARDIAC DEATH
    • DONATION
    • OUTCOMES
    • THROMBOSIS
    • RECIPIENTS
    • IMPACT

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