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Clinical-Trials Of The Prototype Rutherford-Appleton-Laboratory MWPC Positron Camera At The Royal-Marsden-Hospital

Research output: Contribution to journalArticlepeer-review

M. A. Flower, R. J. Ott, S. Webb, M. O. Leach, P. K. Marsden, R. Clack, O. Khan, V. Batty, V. R. McCready, J. E. Bateman

Original languageEnglish
Pages (from-to)350-353
Number of pages4
JournalNuclear Instruments & Methods In Physics Research Section A, Accelerators, Spectrometers, Detectors And Associated Equipment
Issue number2
Published10 Jun 1988

Bibliographical note

M1 - 2 Times Cited: 7

King's Authors


Two clinical trials of the prototype RAL multiwire proportional chamber (MWPC) positron camera were carried out prior to the development of a clinical system with large-area detectors. During the first clinical trial, the patient studies included skeletal imaging using 18F, imaging of brain glucose metabolism using 18F FDG, bone marrow imaging using 52Fe citrate and thyroid imaging with Na124I. Longitudinal tomograms were produced from the limited-angle data acquisition from the static detectors. During the second clinical trial, transaxial, coronal and sagittal images were produced from the multiview data acquisition. A more detailed thyroid study was performed in which the volume of the functioning thyroid tissue was obtained from the 3D PET image and this volume was used in estimating the radiation dose achieved during radioiodine therapy of patients with thyrotoxicosis. Despite the small field of view of the prototype camera, and the use of smaller than usual amounts of activity administered, the PET images were in most cases comparable with, and in a few cases visually better than, the equivalent planar view using a state-of-the-art gamma camera with a large field of view and routine radiopharmaceuticals.

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