Clone competition as a mechanism to reduce tumor formation

Amelia Acha-Sagredo; Ilaria Malanchi; Francesca D Ciccarelli

doi:10.1016/j.devcel.2021.12.003

Clone competition as a mechanism to reduce tumor formation

Comprehensive Cancer Centre

Cancer Systems Biology Laboratory
The Francis Crick Institute, London, UK. [email protected].
School of Cancer & Pharmaceutical Sciences
King's College London

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.

Original language	English
Pages (from-to)	3307-3308
Number of pages	2
Journal	Developmental Cell
Volume	56
Issue number	24
DOIs	https://doi.org/10.1016/j.devcel.2021.12.003
Publication status	Published - 20 Dec 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/j.devcel.2021.12.003

Cite this

@article{682720a8ae4d4d6aa3c06e13dd9e16d2,

title = "Clone competition as a mechanism to reduce tumor formation",

abstract = "With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.",

author = "Amelia Acha-Sagredo and Ilaria Malanchi and Ciccarelli, \{Francesca D\}",

year = "2021",

month = dec,

day = "20",

doi = "10.1016/j.devcel.2021.12.003",

language = "English",

volume = "56",

pages = "3307--3308",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "24",

}

TY - JOUR

T1 - Clone competition as a mechanism to reduce tumor formation

AU - Acha-Sagredo, Amelia

AU - Malanchi, Ilaria

AU - Ciccarelli, Francesca D

PY - 2021/12/20

Y1 - 2021/12/20

N2 - With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.

AB - With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.

U2 - 10.1016/j.devcel.2021.12.003

DO - 10.1016/j.devcel.2021.12.003

M3 - Article

C2 - 34932947

SN - 1534-5807

VL - 56

SP - 3307

EP - 3308

JO - Developmental Cell

JF - Developmental Cell

IS - 24

ER -

Clone competition as a mechanism to reduce tumor formation

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this