Closed-loop oxygen system in late preterm/term, ventilated infants with different severities of respiratory disease

Ourania Kaltsogianni, Theodore Dassios, Christopher Harris, Allan Jenkinson, Rebecca Ann Lee, Masashiro Sugino, Anne Greenough*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Aim: To evaluate closed-loop automated oxygen control (CLAC) in ventilated infants >33 weeks of gestation with different respiratory disease severities. Methods: Infants were studied on two consecutive days for 6 h each day. They were randomised to receive standard care or standard care with CLAC (Oxygenie) first. Analyses were performed of the results of infants with or without an FiO2 ≥ 0.3 and infants with congenital diaphragmatic hernia (CDH). Results: Thirty-one infants with a median (IQR) gestational age of 37.9 (37.1–38.9) weeks were studied at a median postmenstrual age (IQR) of 38.9 (37.4–39.8) weeks. In infants with an FiO2 ≥ 0.3 (n = 8), CLAC increased the time spent in target oxygen range (92–96%) by 61.6% (p = 0.018), whereas in infants with an FiO2 < 0.3, the time in target was increased by 3.8% (p = 0.019). During CLAC, only infants with an FiO2 ≥ 0.3 spent less time in hyperoxemia (SpO2 > 96%) (p = 0.012) and hyperoxemic episodes were shorter (p = 0.012). In both groups, CLAC reduced the duration of desaturations (SpO2 < 92%, p < 0.001). In CDH infants, CLAC increased the time spent in target oxygen range by 34% (p = 0.036) and the median duration of desaturations was reduced (p = 0.028). Conclusion: CLAC may be more useful in infants with more severe respiratory distress.

Original languageEnglish
Pages (from-to)1185-1189
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Volume112
Issue number6
DOIs
Publication statusPublished - Jun 2023

Keywords

  • closed-loop automated oxygen delivery
  • congenital diaphragmatic hernia
  • term infant

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