Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study

Roberto Sansone; Ana Rodriguez-Mateos; Jan Heuel; David Falk; Dominik Schuler; Rabea Wagstaff; Gunter G C Kuhnle; Jeremy P E Spencer; Hagen Schroeter; Marc W Merx; Malte Kelm; Christian Heiss; FLAVIOLA Consortium, European Union 7th Framework Program

doi:10.1017/S0007114515002822

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study

Roberto Sansone, Ana Rodriguez-Mateos, Jan Heuel, David Falk, Dominik Schuler, Rabea Wagstaff, Gunter G C Kuhnle, Jeremy P E Spencer, Hagen Schroeter, Marc W Merx, Malte Kelm, Christian Heiss, FLAVIOLA Consortium, European Union 7th Framework Program

Research output: Contribution to journal › Article › peer-review

131 Citations (Scopus)

Abstract

Cocoa flavanol (CF) intake improves endothelial function in patients with cardiovascular risk factors and disease. We investigated the effects of CF on surrogate markers of cardiovascular health in low risk, healthy, middle-aged individuals without history, signs or symptoms of CVD. In a 1-month, open-label, one-armed pilot study, bi-daily ingestion of 450 mg of CF led to a time-dependent increase in endothelial function (measured as flow-mediated vasodilation (FMD)) that plateaued after 2 weeks. Subsequently, in a randomised, controlled, double-masked, parallel-group dietary intervention trial (Clinicaltrials.gov: NCT01799005), 100 healthy, middle-aged (35-60 years) men and women consumed either the CF-containing drink (450 mg) or a nutrient-matched CF-free control bi-daily for 1 month. The primary end point was FMD. Secondary end points included plasma lipids and blood pressure, thus enabling the calculation of Framingham Risk Scores and pulse wave velocity. At 1 month, CF increased FMD over control by 1·2 % (95 % CI 1·0, 1·4 %). CF decreased systolic and diastolic blood pressure by 4·4 mmHg (95 % CI 7·9, 0·9 mmHg) and 3·9 mmHg (95 % CI 6·7, 0·9 mmHg), pulse wave velocity by 0·4 m/s (95 % CI 0·8, 0·04 m/s), total cholesterol by 0·20 mmol/l (95 % CI 0·39, 0·01 mmol/l) and LDL-cholesterol by 0·17 mmol/l (95 % CI 0·32, 0·02 mmol/l), whereas HDL-cholesterol increased by 0·10 mmol/l (95 % CI 0·04, 0·17 mmol/l). By applying the Framingham Risk Score, CF predicted a significant lowering of 10-year risk for CHD, myocardial infarction, CVD, death from CHD and CVD. In healthy individuals, regular CF intake improved accredited cardiovascular surrogates of cardiovascular risk, demonstrating that dietary flavanols have the potential to maintain cardiovascular health even in low-risk subjects.

Original language	English
Pages (from-to)	1246-55
Number of pages	10
Journal	British Journal of Nutrition
Volume	114
Issue number	8
DOIs	https://doi.org/10.1017/S0007114515002822
Publication status	Published - 28 Oct 2015

Keywords

Adult
Biomarkers
Blood Pressure
Body Mass Index
Cacao
Cardiovascular Diseases
Cholesterol, HDL
Cholesterol, LDL
Double-Blind Method
Endothelium, Vascular
Female
Flavonols
Healthy Volunteers
Humans
Male
Middle Aged
Pilot Projects
Pulse Wave Analysis
Risk Factors
Treatment Outcome
Vasodilation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S0007114515002822

Cite this

Sansone, R., Rodriguez-Mateos, A., Heuel, J., Falk, D., Schuler, D., Wagstaff, R., Kuhnle, G. G. C., Spencer, J. P. E., Schroeter, H., Merx, M. W., Kelm, M., Heiss, C., & FLAVIOLA Consortium, European Union 7th Framework Program (2015). Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. British Journal of Nutrition, 114(8), 1246-55. https://doi.org/10.1017/S0007114515002822

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title = "Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study",

abstract = "Cocoa flavanol (CF) intake improves endothelial function in patients with cardiovascular risk factors and disease. We investigated the effects of CF on surrogate markers of cardiovascular health in low risk, healthy, middle-aged individuals without history, signs or symptoms of CVD. In a 1-month, open-label, one-armed pilot study, bi-daily ingestion of 450 mg of CF led to a time-dependent increase in endothelial function (measured as flow-mediated vasodilation (FMD)) that plateaued after 2 weeks. Subsequently, in a randomised, controlled, double-masked, parallel-group dietary intervention trial (Clinicaltrials.gov: NCT01799005), 100 healthy, middle-aged (35-60 years) men and women consumed either the CF-containing drink (450 mg) or a nutrient-matched CF-free control bi-daily for 1 month. The primary end point was FMD. Secondary end points included plasma lipids and blood pressure, thus enabling the calculation of Framingham Risk Scores and pulse wave velocity. At 1 month, CF increased FMD over control by 1·2 % (95 % CI 1·0, 1·4 %). CF decreased systolic and diastolic blood pressure by 4·4 mmHg (95 % CI 7·9, 0·9 mmHg) and 3·9 mmHg (95 % CI 6·7, 0·9 mmHg), pulse wave velocity by 0·4 m/s (95 % CI 0·8, 0·04 m/s), total cholesterol by 0·20 mmol/l (95 % CI 0·39, 0·01 mmol/l) and LDL-cholesterol by 0·17 mmol/l (95 % CI 0·32, 0·02 mmol/l), whereas HDL-cholesterol increased by 0·10 mmol/l (95 % CI 0·04, 0·17 mmol/l). By applying the Framingham Risk Score, CF predicted a significant lowering of 10-year risk for CHD, myocardial infarction, CVD, death from CHD and CVD. In healthy individuals, regular CF intake improved accredited cardiovascular surrogates of cardiovascular risk, demonstrating that dietary flavanols have the potential to maintain cardiovascular health even in low-risk subjects.",

keywords = "Adult, Biomarkers, Blood Pressure, Body Mass Index, Cacao, Cardiovascular Diseases, Cholesterol, HDL, Cholesterol, LDL, Double-Blind Method, Endothelium, Vascular, Female, Flavonols, Healthy Volunteers, Humans, Male, Middle Aged, Pilot Projects, Pulse Wave Analysis, Risk Factors, Treatment Outcome, Vasodilation",

author = "Roberto Sansone and Ana Rodriguez-Mateos and Jan Heuel and David Falk and Dominik Schuler and Rabea Wagstaff and Kuhnle, {Gunter G C} and Spencer, {Jeremy P E} and Hagen Schroeter and Merx, {Marc W} and Malte Kelm and Christian Heiss and {FLAVIOLA Consortium, European Union 7th Framework Program}",

year = "2015",

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doi = "10.1017/S0007114515002822",

language = "English",

volume = "114",

pages = "1246--55",

journal = "British Journal of Nutrition",

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publisher = "Cambridge University Press",

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Sansone, R, Rodriguez-Mateos, A, Heuel, J, Falk, D, Schuler, D, Wagstaff, R, Kuhnle, GGC , Spencer, JPE , Schroeter, H, Merx, MW, Kelm, M, Heiss, C & FLAVIOLA Consortium, European Union 7th Framework Program 2015, 'Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study', British Journal of Nutrition, vol. 114, no. 8, pp. 1246-55. https://doi.org/10.1017/S0007114515002822

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. / Sansone, Roberto; Rodriguez-Mateos, Ana; Heuel, Jan et al.
In: British Journal of Nutrition, Vol. 114, No. 8, 28.10.2015, p. 1246-55.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women

T2 - a randomised, controlled, double-masked trial: the Flaviola Health Study

AU - Sansone, Roberto

AU - Rodriguez-Mateos, Ana

AU - Heuel, Jan

AU - Falk, David

AU - Schuler, Dominik

AU - Wagstaff, Rabea

AU - Kuhnle, Gunter G C

AU - Spencer, Jeremy P E

AU - Schroeter, Hagen

AU - Merx, Marc W

AU - Kelm, Malte

AU - Heiss, Christian

AU - FLAVIOLA Consortium, European Union 7th Framework Program

PY - 2015/10/28

Y1 - 2015/10/28

N2 - Cocoa flavanol (CF) intake improves endothelial function in patients with cardiovascular risk factors and disease. We investigated the effects of CF on surrogate markers of cardiovascular health in low risk, healthy, middle-aged individuals without history, signs or symptoms of CVD. In a 1-month, open-label, one-armed pilot study, bi-daily ingestion of 450 mg of CF led to a time-dependent increase in endothelial function (measured as flow-mediated vasodilation (FMD)) that plateaued after 2 weeks. Subsequently, in a randomised, controlled, double-masked, parallel-group dietary intervention trial (Clinicaltrials.gov: NCT01799005), 100 healthy, middle-aged (35-60 years) men and women consumed either the CF-containing drink (450 mg) or a nutrient-matched CF-free control bi-daily for 1 month. The primary end point was FMD. Secondary end points included plasma lipids and blood pressure, thus enabling the calculation of Framingham Risk Scores and pulse wave velocity. At 1 month, CF increased FMD over control by 1·2 % (95 % CI 1·0, 1·4 %). CF decreased systolic and diastolic blood pressure by 4·4 mmHg (95 % CI 7·9, 0·9 mmHg) and 3·9 mmHg (95 % CI 6·7, 0·9 mmHg), pulse wave velocity by 0·4 m/s (95 % CI 0·8, 0·04 m/s), total cholesterol by 0·20 mmol/l (95 % CI 0·39, 0·01 mmol/l) and LDL-cholesterol by 0·17 mmol/l (95 % CI 0·32, 0·02 mmol/l), whereas HDL-cholesterol increased by 0·10 mmol/l (95 % CI 0·04, 0·17 mmol/l). By applying the Framingham Risk Score, CF predicted a significant lowering of 10-year risk for CHD, myocardial infarction, CVD, death from CHD and CVD. In healthy individuals, regular CF intake improved accredited cardiovascular surrogates of cardiovascular risk, demonstrating that dietary flavanols have the potential to maintain cardiovascular health even in low-risk subjects.

AB - Cocoa flavanol (CF) intake improves endothelial function in patients with cardiovascular risk factors and disease. We investigated the effects of CF on surrogate markers of cardiovascular health in low risk, healthy, middle-aged individuals without history, signs or symptoms of CVD. In a 1-month, open-label, one-armed pilot study, bi-daily ingestion of 450 mg of CF led to a time-dependent increase in endothelial function (measured as flow-mediated vasodilation (FMD)) that plateaued after 2 weeks. Subsequently, in a randomised, controlled, double-masked, parallel-group dietary intervention trial (Clinicaltrials.gov: NCT01799005), 100 healthy, middle-aged (35-60 years) men and women consumed either the CF-containing drink (450 mg) or a nutrient-matched CF-free control bi-daily for 1 month. The primary end point was FMD. Secondary end points included plasma lipids and blood pressure, thus enabling the calculation of Framingham Risk Scores and pulse wave velocity. At 1 month, CF increased FMD over control by 1·2 % (95 % CI 1·0, 1·4 %). CF decreased systolic and diastolic blood pressure by 4·4 mmHg (95 % CI 7·9, 0·9 mmHg) and 3·9 mmHg (95 % CI 6·7, 0·9 mmHg), pulse wave velocity by 0·4 m/s (95 % CI 0·8, 0·04 m/s), total cholesterol by 0·20 mmol/l (95 % CI 0·39, 0·01 mmol/l) and LDL-cholesterol by 0·17 mmol/l (95 % CI 0·32, 0·02 mmol/l), whereas HDL-cholesterol increased by 0·10 mmol/l (95 % CI 0·04, 0·17 mmol/l). By applying the Framingham Risk Score, CF predicted a significant lowering of 10-year risk for CHD, myocardial infarction, CVD, death from CHD and CVD. In healthy individuals, regular CF intake improved accredited cardiovascular surrogates of cardiovascular risk, demonstrating that dietary flavanols have the potential to maintain cardiovascular health even in low-risk subjects.

KW - Adult

KW - Biomarkers

KW - Blood Pressure

KW - Body Mass Index

KW - Cacao

KW - Cardiovascular Diseases

KW - Cholesterol, HDL

KW - Cholesterol, LDL

KW - Double-Blind Method

KW - Endothelium, Vascular

KW - Female

KW - Flavonols

KW - Healthy Volunteers

KW - Humans

KW - Male

KW - Middle Aged

KW - Pilot Projects

KW - Pulse Wave Analysis

KW - Risk Factors

KW - Treatment Outcome

KW - Vasodilation

U2 - 10.1017/S0007114515002822

DO - 10.1017/S0007114515002822

M3 - Article

C2 - 26348767

SN - 0007-1145

VL - 114

SP - 1246

EP - 1255

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 8

ER -

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study

Abstract

Keywords

UN SDGs

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