TY - JOUR
T1 - Cognition, hallucination severity and hallucination-specific insight in neurodegenerative disorders and eye disease
AU - Montagnese, Marcella
AU - Vignando, Miriam
AU - Collerton, Daniel
AU - Ffytche, Dominic
AU - Mosimann, Urs Peter
AU - Taylor, John-Paul
AU - daSilva Morgan, Katrina
AU - Urwyler, Prabitha
PY - 2021/8/2
Y1 - 2021/8/2
N2 - Introduction: Hallucinations occur across neurodegenerative disorders, with increasing severity, poorer cognition and impaired hallucination-specific insight associated with worse outcomes and faster disease progression. It remains unclear how changes in cognition, temporal aspects of hallucinations, hallucination-specific insight and distress relate to each other. Methods: Extant samples of patients experiencing visual hallucinations were included in the analyses: Parkinson’s Disease (n = 103), Parkinson’s Disease Dementia (n = 41), Dementia with Lewy Bodies (n = 27) and Eye Disease (n = 113). We explored the relationship between factors of interest with Spearman’s correlations and random-effect linear models. Results: Spearman’s correlation analyses at the whole-group level showed that higher hallucination-specific insight was related to higher MMSE score (r
s = 0.39, p < 0.001) and less severe hallucinations (r
s = −0.28, p <.01). Linear mixed-models controlling for diagnostic group showed that insight was related to higher MMSE (p <.001), to hallucination severity (p = 0.003), and to VH duration (p = 0.04). Interestingly, insight was linked to the distress component but not the frequency component of severity. No significant relationship was found between MMSE and hallucination severity in these analyses. Conclusion: Our findings highlight the importance of hallucination-specific insight, distress and duration across groups. A better understanding of the role these factors play in VH may help with the development of future therapeutic interventions trans-diagnostically.
AB - Introduction: Hallucinations occur across neurodegenerative disorders, with increasing severity, poorer cognition and impaired hallucination-specific insight associated with worse outcomes and faster disease progression. It remains unclear how changes in cognition, temporal aspects of hallucinations, hallucination-specific insight and distress relate to each other. Methods: Extant samples of patients experiencing visual hallucinations were included in the analyses: Parkinson’s Disease (n = 103), Parkinson’s Disease Dementia (n = 41), Dementia with Lewy Bodies (n = 27) and Eye Disease (n = 113). We explored the relationship between factors of interest with Spearman’s correlations and random-effect linear models. Results: Spearman’s correlation analyses at the whole-group level showed that higher hallucination-specific insight was related to higher MMSE score (r
s = 0.39, p < 0.001) and less severe hallucinations (r
s = −0.28, p <.01). Linear mixed-models controlling for diagnostic group showed that insight was related to higher MMSE (p <.001), to hallucination severity (p = 0.003), and to VH duration (p = 0.04). Interestingly, insight was linked to the distress component but not the frequency component of severity. No significant relationship was found between MMSE and hallucination severity in these analyses. Conclusion: Our findings highlight the importance of hallucination-specific insight, distress and duration across groups. A better understanding of the role these factors play in VH may help with the development of future therapeutic interventions trans-diagnostically.
UR - http://www.scopus.com/inward/record.url?scp=85111757524&partnerID=8YFLogxK
U2 - 10.1080/13546805.2021.1960812
DO - 10.1080/13546805.2021.1960812
M3 - Article
C2 - 34338592
SN - 1354-6805
JO - Cognitive Neuropsychiatry
JF - Cognitive Neuropsychiatry
ER -