Cognitive decline and risk of dementia in individuals with heart failure: A systematic review and meta-analysis

Swarna Vishwanath; Vazhma Qaderi; Claire J Steves; Christopher M Reid; Ingrid Hopper; Joanne Ryan

doi:10.1016/j.cardfail.2021.12.014

Cognitive decline and risk of dementia in individuals with heart failure: A systematic review and meta-analysis

Swarna Vishwanath, Vazhma Qaderi, Claire J Steves, Christopher M Reid, Ingrid Hopper, Joanne Ryan

Twin Research & Genetic Epidemiology

Monash University
School of Public Health and Preventive Medicine, Monash University, Victoria, Australia; University Heart & Vascular Center Hamburg, Germany.
School of Public Health and Preventive Medicine, Monash University, Victoria, Australia; Curtin School of Population Health, Curtin University, Western Australia, Australia.
School of Public Health and Preventive Medicine, Monash University, Victoria, Australia. Electronic address: [email protected].

Research output: Contribution to journal › Review article › peer-review

27 Citations (Scopus)

Abstract

To determine the association between heart failure (HF) and cognitive change and dementia. Systematic search of three electronic databases was performed and 29 eligible studies involving approximately 3 million participants were identified. Twelve studies examined dementia and 20 cognitive change, but only a subset of studies could be included in the meta-analysis. These findings indicated that HF was not significantly associated with dementia (n=8, hazard ratio [HR] 1.18, 95% confidence interval [CI] [0.93, 1.50]), but increased the risk of cognitive impairment (n=3, HR 1.80, 95%CI [1.14,2.86]) . Additionally, HF was associated with poorer mean cognitive performance in global cognition (Hedges' g -0.73, 95%CI [-1.12, -0.35]), memory (Hedges' g -0.57, 95%CI [-0.72, -0.42]), executive function (Hedges' g -0.58, 95%CI [-0.72, -0.43]), attention/speed (Hedges' g -0.50, 95%CI [-0.63, -0.37]) and language (Hedges' g -0.61, 95%CI [-1.05, -0.17]). Patients with HF perform worse on all cognitive tests, and have an increased risk of cognitive impairment. These findings highlight the need for clinicians to consider cognition as part of routine care for patients with HF. [Abstract copyright: Copyright © 2021. Published by Elsevier Inc.]

Original language	English
Journal	Journal of cardiac failure
Early online date	28 Dec 2021
DOIs	https://doi.org/10.1016/j.cardfail.2021.12.014
Publication status	E-pub ahead of print - 28 Dec 2021

Keywords

dementia
cognitive impairment
cognition
Heart failure
cognitive decline
Alzheimer's disease

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10.1016/j.cardfail.2021.12.014

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title = "Cognitive decline and risk of dementia in individuals with heart failure: A systematic review and meta-analysis",

abstract = "To determine the association between heart failure (HF) and cognitive change and dementia. Systematic search of three electronic databases was performed and 29 eligible studies involving approximately 3 million participants were identified. Twelve studies examined dementia and 20 cognitive change, but only a subset of studies could be included in the meta-analysis. These findings indicated that HF was not significantly associated with dementia (n=8, hazard ratio [HR] 1.18, 95% confidence interval [CI] [0.93, 1.50]), but increased the risk of cognitive impairment (n=3, HR 1.80, 95%CI [1.14,2.86]) . Additionally, HF was associated with poorer mean cognitive performance in global cognition (Hedges' g -0.73, 95%CI [-1.12, -0.35]), memory (Hedges' g -0.57, 95%CI [-0.72, -0.42]), executive function (Hedges' g -0.58, 95%CI [-0.72, -0.43]), attention/speed (Hedges' g -0.50, 95%CI [-0.63, -0.37]) and language (Hedges' g -0.61, 95%CI [-1.05, -0.17]). Patients with HF perform worse on all cognitive tests, and have an increased risk of cognitive impairment. These findings highlight the need for clinicians to consider cognition as part of routine care for patients with HF. [Abstract copyright: Copyright {\textcopyright} 2021. Published by Elsevier Inc.]",

keywords = "dementia, cognitive impairment, cognition, Heart failure, cognitive decline, Alzheimer's disease",

author = "Swarna Vishwanath and Vazhma Qaderi and Steves, {Claire J} and Reid, {Christopher M} and Ingrid Hopper and Joanne Ryan",

year = "2021",

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doi = "10.1016/j.cardfail.2021.12.014",

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journal = "Journal of cardiac failure",

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T1 - Cognitive decline and risk of dementia in individuals with heart failure: A systematic review and meta-analysis

AU - Vishwanath, Swarna

AU - Qaderi, Vazhma

AU - Steves, Claire J

AU - Reid, Christopher M

AU - Hopper, Ingrid

AU - Ryan, Joanne

PY - 2021/12/28

Y1 - 2021/12/28

N2 - To determine the association between heart failure (HF) and cognitive change and dementia. Systematic search of three electronic databases was performed and 29 eligible studies involving approximately 3 million participants were identified. Twelve studies examined dementia and 20 cognitive change, but only a subset of studies could be included in the meta-analysis. These findings indicated that HF was not significantly associated with dementia (n=8, hazard ratio [HR] 1.18, 95% confidence interval [CI] [0.93, 1.50]), but increased the risk of cognitive impairment (n=3, HR 1.80, 95%CI [1.14,2.86]) . Additionally, HF was associated with poorer mean cognitive performance in global cognition (Hedges' g -0.73, 95%CI [-1.12, -0.35]), memory (Hedges' g -0.57, 95%CI [-0.72, -0.42]), executive function (Hedges' g -0.58, 95%CI [-0.72, -0.43]), attention/speed (Hedges' g -0.50, 95%CI [-0.63, -0.37]) and language (Hedges' g -0.61, 95%CI [-1.05, -0.17]). Patients with HF perform worse on all cognitive tests, and have an increased risk of cognitive impairment. These findings highlight the need for clinicians to consider cognition as part of routine care for patients with HF. [Abstract copyright: Copyright © 2021. Published by Elsevier Inc.]

AB - To determine the association between heart failure (HF) and cognitive change and dementia. Systematic search of three electronic databases was performed and 29 eligible studies involving approximately 3 million participants were identified. Twelve studies examined dementia and 20 cognitive change, but only a subset of studies could be included in the meta-analysis. These findings indicated that HF was not significantly associated with dementia (n=8, hazard ratio [HR] 1.18, 95% confidence interval [CI] [0.93, 1.50]), but increased the risk of cognitive impairment (n=3, HR 1.80, 95%CI [1.14,2.86]) . Additionally, HF was associated with poorer mean cognitive performance in global cognition (Hedges' g -0.73, 95%CI [-1.12, -0.35]), memory (Hedges' g -0.57, 95%CI [-0.72, -0.42]), executive function (Hedges' g -0.58, 95%CI [-0.72, -0.43]), attention/speed (Hedges' g -0.50, 95%CI [-0.63, -0.37]) and language (Hedges' g -0.61, 95%CI [-1.05, -0.17]). Patients with HF perform worse on all cognitive tests, and have an increased risk of cognitive impairment. These findings highlight the need for clinicians to consider cognition as part of routine care for patients with HF. [Abstract copyright: Copyright © 2021. Published by Elsevier Inc.]

KW - dementia

KW - cognitive impairment

KW - cognition

KW - Heart failure

KW - cognitive decline

KW - Alzheimer's disease

U2 - 10.1016/j.cardfail.2021.12.014

DO - 10.1016/j.cardfail.2021.12.014

M3 - Review article

C2 - 34971812

SN - 1532-8414

JO - Journal of cardiac failure

JF - Journal of cardiac failure

ER -

Cognitive decline and risk of dementia in individuals with heart failure: A systematic review and meta-analysis

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Keywords

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