Cognitive function at first episode in patients subsequently developing treatment-resistant schizophrenia

Juan M Aguirre; Camila Díaz Dellarossa; Daniella Barbagelata; Javiera Vásquez; Cristián Mena; Ángeles Tepper; Juan Pablo Ramírez-Mahaluf; David Aceituno; Rubén Nachar; Juan Undurraga; Alfonso González-Valderrama; Nicolas A Crossley

doi:10.1016/j.schres.2025.01.017

Cognitive function at first episode in patients subsequently developing treatment-resistant schizophrenia

Juan M Aguirre, Camila Díaz Dellarossa, Daniella Barbagelata, Javiera Vásquez, Cristián Mena, Ángeles Tepper, Juan Pablo Ramírez-Mahaluf, David Aceituno, Rubén Nachar, Juan Undurraga, Alfonso González-Valderrama, Nicolas A Crossley

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: Research on cognitive functions in treatment-resistant schizophrenia (TRS) has focused on chronic patients, complicating the distinction between disease-related deficits from those influenced by chronicity or antipsychotic exposure. Identifying early cognitive differences could offer insights into the nature of TRS cognitive performance and serve as potential markers of treatment resistance. METHODS: Cohort study of 81 first-episode schizophrenia patients from Chile. Patients were followed-up and classified as TRS if they met TRRIP criteria or were prescribed clozapine at any point. 57 healthy controls were recruited for group comparisons. Cognitive performance was assessed using the MATRICS Consensus Cognitive Battery. RESULTS: 51 patients were allocated to the treatment-responsive group (TRESP) and 30 to the TRS sample. Multivariable analyses controlling for age and sex revealed a worse TRS performance in processing speed, verbal fluency, attention/vigilance and working memory (p values

Original language	English
Pages (from-to)	178-184
Number of pages	7
Journal	Schizophrenia Research
Volume	276
Early online date	2 Feb 2025
DOIs	https://doi.org/10.1016/j.schres.2025.01.017
Publication status	E-pub ahead of print - 2 Feb 2025

Keywords

Cognitive impairment
Cohort study
First-episode
Neuropsychological
Schizophrenia
Treatment-resistance
5. Publications

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Aguirre, J. M., Díaz Dellarossa, C., Barbagelata, D., Vásquez, J., Mena, C., Tepper, Á., Ramírez-Mahaluf, J. P., Aceituno, D., Nachar, R., Undurraga, J., González-Valderrama, A., & Crossley, N. A. (2025). Cognitive function at first episode in patients subsequently developing treatment-resistant schizophrenia. Schizophrenia Research, 276, 178-184. Advance online publication. https://doi.org/10.1016/j.schres.2025.01.017

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abstract = "BACKGROUND: Research on cognitive functions in treatment-resistant schizophrenia (TRS) has focused on chronic patients, complicating the distinction between disease-related deficits from those influenced by chronicity or antipsychotic exposure. Identifying early cognitive differences could offer insights into the nature of TRS cognitive performance and serve as potential markers of treatment resistance. METHODS: Cohort study of 81 first-episode schizophrenia patients from Chile. Patients were followed-up and classified as TRS if they met TRRIP criteria or were prescribed clozapine at any point. 57 healthy controls were recruited for group comparisons. Cognitive performance was assessed using the MATRICS Consensus Cognitive Battery. RESULTS: 51 patients were allocated to the treatment-responsive group (TRESP) and 30 to the TRS sample. Multivariable analyses controlling for age and sex revealed a worse TRS performance in processing speed, verbal fluency, attention/vigilance and working memory (p values ",

keywords = "Cognitive impairment, Cohort study, First-episode, Neuropsychological, Schizophrenia, Treatment-resistance, 5. Publications",

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Aguirre, JM, Díaz Dellarossa, C, Barbagelata, D, Vásquez, J, Mena, C, Tepper, Á, Ramírez-Mahaluf, JP, Aceituno, D, Nachar, R, Undurraga, J, González-Valderrama, A & Crossley, NA 2025, 'Cognitive function at first episode in patients subsequently developing treatment-resistant schizophrenia', Schizophrenia Research, vol. 276, pp. 178-184. https://doi.org/10.1016/j.schres.2025.01.017

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T1 - Cognitive function at first episode in patients subsequently developing treatment-resistant schizophrenia

AU - Aguirre, Juan M

AU - Díaz Dellarossa, Camila

AU - Barbagelata, Daniella

AU - Vásquez, Javiera

AU - Mena, Cristián

AU - Tepper, Ángeles

AU - Ramírez-Mahaluf, Juan Pablo

AU - Aceituno, David

AU - Nachar, Rubén

AU - Undurraga, Juan

AU - González-Valderrama, Alfonso

AU - Crossley, Nicolas A

PY - 2025/2/2

Y1 - 2025/2/2

N2 - BACKGROUND: Research on cognitive functions in treatment-resistant schizophrenia (TRS) has focused on chronic patients, complicating the distinction between disease-related deficits from those influenced by chronicity or antipsychotic exposure. Identifying early cognitive differences could offer insights into the nature of TRS cognitive performance and serve as potential markers of treatment resistance. METHODS: Cohort study of 81 first-episode schizophrenia patients from Chile. Patients were followed-up and classified as TRS if they met TRRIP criteria or were prescribed clozapine at any point. 57 healthy controls were recruited for group comparisons. Cognitive performance was assessed using the MATRICS Consensus Cognitive Battery. RESULTS: 51 patients were allocated to the treatment-responsive group (TRESP) and 30 to the TRS sample. Multivariable analyses controlling for age and sex revealed a worse TRS performance in processing speed, verbal fluency, attention/vigilance and working memory (p values

AB - BACKGROUND: Research on cognitive functions in treatment-resistant schizophrenia (TRS) has focused on chronic patients, complicating the distinction between disease-related deficits from those influenced by chronicity or antipsychotic exposure. Identifying early cognitive differences could offer insights into the nature of TRS cognitive performance and serve as potential markers of treatment resistance. METHODS: Cohort study of 81 first-episode schizophrenia patients from Chile. Patients were followed-up and classified as TRS if they met TRRIP criteria or were prescribed clozapine at any point. 57 healthy controls were recruited for group comparisons. Cognitive performance was assessed using the MATRICS Consensus Cognitive Battery. RESULTS: 51 patients were allocated to the treatment-responsive group (TRESP) and 30 to the TRS sample. Multivariable analyses controlling for age and sex revealed a worse TRS performance in processing speed, verbal fluency, attention/vigilance and working memory (p values

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KW - Cohort study

KW - First-episode

KW - Neuropsychological

KW - Schizophrenia

KW - Treatment-resistance

KW - 5. Publications

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DO - 10.1016/j.schres.2025.01.017

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SN - 0920-9964

VL - 276

SP - 178

EP - 184

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -

Cognitive function at first episode in patients subsequently developing treatment-resistant schizophrenia

Abstract

Keywords

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