Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group

Iva Stankovic; Florian Krismer; Aleksandar Jesic; Angelo Antonini; Thomas Benke; Richard G Brown; David J Burn; Janice L Holton; Horacio Kaufmann; Vladimir S Kostic; Helen Ling; Wassilios G Meissner; Werner Poewe; Marija Semnic; Klaus Seppi; Atsushi Takeda; Daniel Weintraub; Gregor K Wenning; Movement Disorders Society MSA (MODIMSA) Study Group

doi:10.1002/mds.25880

Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group

Iva Stankovic, Florian Krismer, Aleksandar Jesic, Angelo Antonini, Thomas Benke, Richard G Brown, David J Burn, Janice L Holton, Horacio Kaufmann, Vladimir S Kostic, Helen Ling, Wassilios G Meissner, Werner Poewe, Marija Semnic, Klaus Seppi, Atsushi Takeda, Daniel Weintraub, Gregor K Wenning, Movement Disorders Society MSA (MODIMSA) Study Group

Research output: Contribution to journal › Article › peer-review

207 Citations (Scopus)

Abstract

Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions also may be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation, with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.

Original language	English
Pages (from-to)	857-867
Number of pages	11
Journal	Movement disorders : official journal of the Movement Disorder Society
Volume	29
Issue number	7
DOIs	https://doi.org/10.1002/mds.25880
Publication status	Published - Jun 2014

Keywords

Animals
Cognition
Cognition Disorders
Dementia
Humans
Memory
Multiple System Atrophy
Neuropsychological Tests

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10.1002/mds.25880

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Stankovic, I., Krismer, F., Jesic, A., Antonini, A., Benke, T., Brown, R. G., Burn, D. J., Holton, J. L., Kaufmann, H., Kostic, V. S., Ling, H., Meissner, W. G., Poewe, W., Semnic, M., Seppi, K., Takeda, A., Weintraub, D., Wenning, G. K., & Movement Disorders Society MSA (MODIMSA) Study Group (2014). Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group. Movement disorders : official journal of the Movement Disorder Society, 29(7), 857-867. https://doi.org/10.1002/mds.25880

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title = "Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group",

abstract = "Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions also may be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation, with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.",

keywords = "Animals, Cognition, Cognition Disorders, Dementia, Humans, Memory, Multiple System Atrophy, Neuropsychological Tests",

author = "Iva Stankovic and Florian Krismer and Aleksandar Jesic and Angelo Antonini and Thomas Benke and Brown, {Richard G} and Burn, {David J} and Holton, {Janice L} and Horacio Kaufmann and Kostic, {Vladimir S} and Helen Ling and Meissner, {Wassilios G} and Werner Poewe and Marija Semnic and Klaus Seppi and Atsushi Takeda and Daniel Weintraub and Wenning, {Gregor K} and {Movement Disorders Society MSA (MODIMSA) Study Group}",

year = "2014",

month = jun,

doi = "10.1002/mds.25880",

language = "English",

volume = "29",

pages = "857--867",

journal = "Movement disorders : official journal of the Movement Disorder Society",

issn = "0885-3185",

publisher = "Wiley",

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Stankovic, I, Krismer, F, Jesic, A, Antonini, A, Benke, T, Brown, RG, Burn, DJ, Holton, JL, Kaufmann, H, Kostic, VS, Ling, H, Meissner, WG, Poewe, W, Semnic, M, Seppi, K, Takeda, A, Weintraub, D, Wenning, GK & Movement Disorders Society MSA (MODIMSA) Study Group 2014, 'Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group', Movement disorders : official journal of the Movement Disorder Society, vol. 29, no. 7, pp. 857-867. https://doi.org/10.1002/mds.25880

Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group. / Stankovic, Iva; Krismer, Florian; Jesic, Aleksandar et al.
In: Movement disorders : official journal of the Movement Disorder Society, Vol. 29, No. 7, 06.2014, p. 857-867.

Research output: Contribution to journal › Article › peer-review

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T1 - Cognitive impairment in multiple system atrophy

T2 - a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group

AU - Stankovic, Iva

AU - Krismer, Florian

AU - Jesic, Aleksandar

AU - Antonini, Angelo

AU - Benke, Thomas

AU - Brown, Richard G

AU - Burn, David J

AU - Holton, Janice L

AU - Kaufmann, Horacio

AU - Kostic, Vladimir S

AU - Ling, Helen

AU - Meissner, Wassilios G

AU - Poewe, Werner

AU - Semnic, Marija

AU - Seppi, Klaus

AU - Takeda, Atsushi

AU - Weintraub, Daniel

AU - Wenning, Gregor K

AU - Movement Disorders Society MSA (MODIMSA) Study Group

PY - 2014/6

Y1 - 2014/6

N2 - Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions also may be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation, with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.

AB - Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions also may be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation, with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.

KW - Animals

KW - Cognition

KW - Cognition Disorders

KW - Dementia

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KW - Memory

KW - Multiple System Atrophy

KW - Neuropsychological Tests

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DO - 10.1002/mds.25880

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SN - 0885-3185

VL - 29

SP - 857

EP - 867

JO - Movement disorders : official journal of the Movement Disorder Society

JF - Movement disorders : official journal of the Movement Disorder Society

IS - 7

ER -

Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group

Abstract

Keywords

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