Cognitive impairment in people with schizophrenia: an umbrella review

Yohannes Gebreegziabhere; Kassahun Habatmu; Awoke Mihretu; Matteo Cella; Atalay Alem

doi:10.1007/s00406-022-01416-6

Cognitive impairment in people with schizophrenia: an umbrella review

Yohannes Gebreegziabhere^*, Kassahun Habatmu, Awoke Mihretu, Matteo Cella, Atalay Alem

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Review article › peer-review

70 Citations (Scopus)

Abstract

Cognitive impairment is one of the core symptoms of schizophrenia. Quite a number of systematic reviews were published related to cognitive impairment in people with schizophrenia (PWS). This umbrella review, therefore, aimed at reviewing and synthesizing the findings of systematic reviews related to domains of cognition impaired and associated factors in PWS. We searched four electronic databases. Data related to domains, occurrence, and associated factors of cognitive impairment in PWS were extracted. The quality of all eligible systematic reviews was assessed using A MeaSurement Tool to Assess methodological quality of systematic Review (AMSTAR) tool. Results are summarized and presented in a narrative form. We identified 63 systematic reviews fulfilling the eligibility criteria. The included reviews showed that PWS had lower cognitive functioning compared to both healthy controls and people with affective disorders. Similar findings were reported among psychotropic free cases and people with first episode psychosis. Greater impairment of cognition was reported in processing speed, verbal memory, and working memory domains. Greater cognitive impairment was reported to be associated with worse functionality and poor insight. Cognitive impairment was also reported to be associated with childhood trauma and aggressive behaviour. According to our quality assessment, the majority of the reviews had moderate quality. We were able to find a good number of systematic reviews on cognitive impairment in PWS. The reviews showed that PWS had higher impairment in different cognitive domains compared to healthy controls and people with affective disorders. Impairment in domains of memory and processing speed were reported frequently.

Original language	English
Pages (from-to)	1139-1155
Number of pages	17
Journal	European archives of psychiatry and clinical neuroscience
Volume	272
Issue number	7
Early online date	28 May 2022
DOIs	https://doi.org/10.1007/s00406-022-01416-6
Publication status	Published - Oct 2022

Keywords

Cognitive impairment
Determinants
Domains impaired
Schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Cognitive impairment in people with schizophrenia: an umbrella review",

abstract = "Cognitive impairment is one of the core symptoms of schizophrenia. Quite a number of systematic reviews were published related to cognitive impairment in people with schizophrenia (PWS). This umbrella review, therefore, aimed at reviewing and synthesizing the findings of systematic reviews related to domains of cognition impaired and associated factors in PWS. We searched four electronic databases. Data related to domains, occurrence, and associated factors of cognitive impairment in PWS were extracted. The quality of all eligible systematic reviews was assessed using A MeaSurement Tool to Assess methodological quality of systematic Review (AMSTAR) tool. Results are summarized and presented in a narrative form. We identified 63 systematic reviews fulfilling the eligibility criteria. The included reviews showed that PWS had lower cognitive functioning compared to both healthy controls and people with affective disorders. Similar findings were reported among psychotropic free cases and people with first episode psychosis. Greater impairment of cognition was reported in processing speed, verbal memory, and working memory domains. Greater cognitive impairment was reported to be associated with worse functionality and poor insight. Cognitive impairment was also reported to be associated with childhood trauma and aggressive behaviour. According to our quality assessment, the majority of the reviews had moderate quality. We were able to find a good number of systematic reviews on cognitive impairment in PWS. The reviews showed that PWS had higher impairment in different cognitive domains compared to healthy controls and people with affective disorders. Impairment in domains of memory and processing speed were reported frequently.",

keywords = "Cognitive impairment, Determinants, Domains impaired, Schizophrenia",

author = "Yohannes Gebreegziabhere and Kassahun Habatmu and Awoke Mihretu and Matteo Cella and Atalay Alem",

note = "Funding Information: This work was supported by the DELTAS Africa Initiative [DEL-15-01] through the first author (YG). The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS){\textquoteright}s Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africa{\textquoteright}s Development Planning and Coordinating Agency (NEPAD Agency) with funding from the Wellcome Trust [DEL-15-01] and the UK government. The views expressed in this publication are those of the author(s) and not necessarily those of AAS, NEPAD Agency, Wellcome Trust or the UK government. The funder has no role in the interpretation of findings and decision for publication. Funding Information: Our special thanks goes to the staff of the Department of Psychiatry, Addis Ababa University, who provided valuable comments on different occasions. We also would like to thank Debre Berhan University for sponsoring the primary investigator to conduct this review. Finally, we would like to thank the African Mental Health Research Initiative (AMARI), because this work was supported by the DELTAS Africa Initiative [DEL-15-01] through the first author (YG). The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS){\textquoteright}s Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africa{\textquoteright}s Development Planning and Coordinating Agency (NEPAD Agency) with funding from the Wellcome Trust [DEL-15-01] and the UK government. The views expressed in this publication are those of the author(s) and not necessarily those of AAS, NEPAD Agency, WellcomeTrust or the UK government. Funding Information: Our special thanks goes to the staff of the Department of Psychiatry, Addis Ababa University, who provided valuable comments on different occasions. We also would like to thank Debre Berhan University for sponsoring the primary investigator to conduct this review. Finally, we would like to thank the African Mental Health Research Initiative (AMARI), because this work was supported by the DELTAS Africa Initiative [DEL-15-01] through the first author (YG). The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS){\textquoteright}s Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africa{\textquoteright}s Development Planning and Coordinating Agency (NEPAD Agency) with funding from the Wellcome Trust [DEL-15-01] and the UK government. The views expressed in this publication are those of the author(s) and not necessarily those of AAS, NEPAD Agency, WellcomeTrust or the UK government. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = oct,

doi = "10.1007/s00406-022-01416-6",

language = "English",

volume = "272",

pages = "1139--1155",

journal = "European archives of psychiatry and clinical neuroscience",

issn = "0940-1334",

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AU - Gebreegziabhere, Yohannes

AU - Habatmu, Kassahun

AU - Mihretu, Awoke

AU - Cella, Matteo

AU - Alem, Atalay

N1 - Funding Information: This work was supported by the DELTAS Africa Initiative [DEL-15-01] through the first author (YG). The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS)’s Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africa’s Development Planning and Coordinating Agency (NEPAD Agency) with funding from the Wellcome Trust [DEL-15-01] and the UK government. The views expressed in this publication are those of the author(s) and not necessarily those of AAS, NEPAD Agency, Wellcome Trust or the UK government. The funder has no role in the interpretation of findings and decision for publication. Funding Information: Our special thanks goes to the staff of the Department of Psychiatry, Addis Ababa University, who provided valuable comments on different occasions. We also would like to thank Debre Berhan University for sponsoring the primary investigator to conduct this review. Finally, we would like to thank the African Mental Health Research Initiative (AMARI), because this work was supported by the DELTAS Africa Initiative [DEL-15-01] through the first author (YG). The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS)’s Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africa’s Development Planning and Coordinating Agency (NEPAD Agency) with funding from the Wellcome Trust [DEL-15-01] and the UK government. The views expressed in this publication are those of the author(s) and not necessarily those of AAS, NEPAD Agency, WellcomeTrust or the UK government. Funding Information: Our special thanks goes to the staff of the Department of Psychiatry, Addis Ababa University, who provided valuable comments on different occasions. We also would like to thank Debre Berhan University for sponsoring the primary investigator to conduct this review. Finally, we would like to thank the African Mental Health Research Initiative (AMARI), because this work was supported by the DELTAS Africa Initiative [DEL-15-01] through the first author (YG). The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS)’s Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africa’s Development Planning and Coordinating Agency (NEPAD Agency) with funding from the Wellcome Trust [DEL-15-01] and the UK government. The views expressed in this publication are those of the author(s) and not necessarily those of AAS, NEPAD Agency, WellcomeTrust or the UK government. Publisher Copyright: © 2022, The Author(s).

PY - 2022/10

Y1 - 2022/10

N2 - Cognitive impairment is one of the core symptoms of schizophrenia. Quite a number of systematic reviews were published related to cognitive impairment in people with schizophrenia (PWS). This umbrella review, therefore, aimed at reviewing and synthesizing the findings of systematic reviews related to domains of cognition impaired and associated factors in PWS. We searched four electronic databases. Data related to domains, occurrence, and associated factors of cognitive impairment in PWS were extracted. The quality of all eligible systematic reviews was assessed using A MeaSurement Tool to Assess methodological quality of systematic Review (AMSTAR) tool. Results are summarized and presented in a narrative form. We identified 63 systematic reviews fulfilling the eligibility criteria. The included reviews showed that PWS had lower cognitive functioning compared to both healthy controls and people with affective disorders. Similar findings were reported among psychotropic free cases and people with first episode psychosis. Greater impairment of cognition was reported in processing speed, verbal memory, and working memory domains. Greater cognitive impairment was reported to be associated with worse functionality and poor insight. Cognitive impairment was also reported to be associated with childhood trauma and aggressive behaviour. According to our quality assessment, the majority of the reviews had moderate quality. We were able to find a good number of systematic reviews on cognitive impairment in PWS. The reviews showed that PWS had higher impairment in different cognitive domains compared to healthy controls and people with affective disorders. Impairment in domains of memory and processing speed were reported frequently.

AB - Cognitive impairment is one of the core symptoms of schizophrenia. Quite a number of systematic reviews were published related to cognitive impairment in people with schizophrenia (PWS). This umbrella review, therefore, aimed at reviewing and synthesizing the findings of systematic reviews related to domains of cognition impaired and associated factors in PWS. We searched four electronic databases. Data related to domains, occurrence, and associated factors of cognitive impairment in PWS were extracted. The quality of all eligible systematic reviews was assessed using A MeaSurement Tool to Assess methodological quality of systematic Review (AMSTAR) tool. Results are summarized and presented in a narrative form. We identified 63 systematic reviews fulfilling the eligibility criteria. The included reviews showed that PWS had lower cognitive functioning compared to both healthy controls and people with affective disorders. Similar findings were reported among psychotropic free cases and people with first episode psychosis. Greater impairment of cognition was reported in processing speed, verbal memory, and working memory domains. Greater cognitive impairment was reported to be associated with worse functionality and poor insight. Cognitive impairment was also reported to be associated with childhood trauma and aggressive behaviour. According to our quality assessment, the majority of the reviews had moderate quality. We were able to find a good number of systematic reviews on cognitive impairment in PWS. The reviews showed that PWS had higher impairment in different cognitive domains compared to healthy controls and people with affective disorders. Impairment in domains of memory and processing speed were reported frequently.

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KW - Determinants

KW - Domains impaired

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Cognitive impairment in people with schizophrenia: an umbrella review

Abstract

Keywords

UN SDGs

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