Cohort Profile: The Stroke in Sierra Leone (SISLE) Register

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The Stroke in Sierra Leone (SISLE) register recruited all patients aged 18 years and over and presenting with the World Health Organization definition of stroke at the two principal adult tertiary hospitals in Freetown, Sierra Leone: Connaught Teaching Hospital and 34th Military Hospital. Patient charges for hospital admission and investigations, including neuroimaging, were paid by the study to reduce the cost barrier to accessing care and to minimize selection bias onto the register.

All patients underwent standardized sociodemographic and risk factor assessment, followed by the measurement of National Institute of Health Stroke Scale (NIHSS), Barthel Index, Modified Rankin Scale (mRS), and EQ-5D-3L by a trained research team, upon admission. Biochemical data collection and neuroimaging were conducted during admission. Classification of pathological stroke subtype was conducted by an experienced stroke physician, with reference to the case history, investigation results and imaging.

From 1 June 2019 until 30 September 2021, the register recruited 986 people with confirmed stroke. Of these, 857 (87%) underwent neuroimaging. 625 (63%) were ischaemic, 206 (21%) experienced primary intracerebral haemorrhage, 25 (3%) experienced subarachnoid haemorrhage and 130 (13%) were of undetermined stroke type.

Participants were followed up at 90 days and 1 year post stroke. Follow-up rates were 88.3% at 90 days and 81.5% at 1 year for participants alive at last point of contact.

The SISLE anonymized dataset is available upon request to researchers, see data access section.
Original languageEnglish
Article numberdyad112
Pages (from-to)e308-e314
JournalInternational Journal of Epidemiology
Issue number6
Early online date9 Aug 2023
Publication statusPublished - 9 Aug 2023


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