Colchicine: An effective treatment for refractory malignant pericardial effusion

T Ng; A Gatt; A Pagliuca; G J Mufti

doi:10.1159/000046519

Colchicine: An effective treatment for refractory malignant pericardial effusion

T Ng, A Gatt, A Pagliuca, G J Mufti

Cell Imaging

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Abstract

We report a patient with AL amyloidosis and chemoresistant light-chain multiple myeloma who developed a progressive malignant pericardial effusion leading to cardiac tamponade. Despite pericardiocentesis and surgical intervention, the pericardial effusion failed to resolve. The administration of oral colchicine produced symptomatic relief within 5 days, with the resolution of pericardial effusion after 14 days of treatment. As the administration of colchicine is simple and the side-effect is usually minimal, further studies are warranted to establish the feasibility of using colchicine to treat malignant pericardial effusion. Copyright (C) 2001 S. Karger AG, Basel.

Original language	English
Pages (from-to)	217 - 219
Number of pages	3
Journal	Acta Haematologica
Volume	104
Issue number	4
DOIs	https://doi.org/10.1159/000046519
Publication status	Published - 2000

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title = "Colchicine: An effective treatment for refractory malignant pericardial effusion",

abstract = "We report a patient with AL amyloidosis and chemoresistant light-chain multiple myeloma who developed a progressive malignant pericardial effusion leading to cardiac tamponade. Despite pericardiocentesis and surgical intervention, the pericardial effusion failed to resolve. The administration of oral colchicine produced symptomatic relief within 5 days, with the resolution of pericardial effusion after 14 days of treatment. As the administration of colchicine is simple and the side-effect is usually minimal, further studies are warranted to establish the feasibility of using colchicine to treat malignant pericardial effusion. Copyright (C) 2001 S. Karger AG, Basel.",

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AU - Gatt, A

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AU - Mufti, G J

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N2 - We report a patient with AL amyloidosis and chemoresistant light-chain multiple myeloma who developed a progressive malignant pericardial effusion leading to cardiac tamponade. Despite pericardiocentesis and surgical intervention, the pericardial effusion failed to resolve. The administration of oral colchicine produced symptomatic relief within 5 days, with the resolution of pericardial effusion after 14 days of treatment. As the administration of colchicine is simple and the side-effect is usually minimal, further studies are warranted to establish the feasibility of using colchicine to treat malignant pericardial effusion. Copyright (C) 2001 S. Karger AG, Basel.

AB - We report a patient with AL amyloidosis and chemoresistant light-chain multiple myeloma who developed a progressive malignant pericardial effusion leading to cardiac tamponade. Despite pericardiocentesis and surgical intervention, the pericardial effusion failed to resolve. The administration of oral colchicine produced symptomatic relief within 5 days, with the resolution of pericardial effusion after 14 days of treatment. As the administration of colchicine is simple and the side-effect is usually minimal, further studies are warranted to establish the feasibility of using colchicine to treat malignant pericardial effusion. Copyright (C) 2001 S. Karger AG, Basel.

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ER -

Colchicine: An effective treatment for refractory malignant pericardial effusion

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