Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression--study protocol

David A Richards; Adwoa Hughes-Morley; Rachel A Hayes; Ricardo Araya; Michael Barkham; John M Bland; Peter Bower; John Cape; Carolyn A Chew-Graham; Linda Gask; Simon Gilbody; Colin Green; David Kessler; Glyn Lewis; Karina Lovell; Chris Manning; Stephen Pilling

doi:10.1186/1472-6963-9-188

Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression--study protocol

David A Richards, Adwoa Hughes-Morley, Rachel A Hayes, Ricardo Araya, Michael Barkham, John M Bland, Peter Bower, John Cape, Carolyn A Chew-Graham, Linda Gask, Simon Gilbody, Colin Green, David Kessler, Glyn Lewis, Karina Lovell, Chris Manning, Stephen Pilling

University of Exeter

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

BACKGROUND: Comprising of both organisational and patient level components, collaborative care is a potentially powerful intervention for improving depression treatment in UK primary Care. However, as previous models have been developed and evaluated in the United States, it is necessary to establish the effect of collaborative care in the UK in order to determine whether this innovative treatment model can replicate benefits for patients outside the US. This Phase III trial was preceded by a Phase II patient level RCT, following the MRC Complex Intervention Framework.

METHODS/DESIGN: A multi-centre controlled trial with cluster-randomised allocation of GP practices. GP practices will be randomised to usual care control or to "collaborative care" - a combination of case manager coordinated support and brief psychological treatment, enhanced specialist and GP communication. The primary outcome will be symptoms of depression as assessed by the PHQ-9.

DISCUSSION: If collaborative care is demonstrated to be effective we will have evidence to enable the NHS to substantially improve the organisation of depressed patients in primary care, and to assist primary care providers to deliver a model of enhanced depression care which is both effective and acceptable to patients.

Original language	English
Journal	BMC Health Services Research
Volume	9
Issue number	188
DOIs	https://doi.org/10.1186/1472-6963-9-188
Publication status	Published - 16 Oct 2009

Keywords

Case Management
Cooperative Behavior
Cost-Benefit Analysis
Depressive Disorder
Family Practice
Female
Humans
Male
Patient-Centered Care
Primary Health Care
Randomized Controlled Trials as Topic
United Kingdom
Clinical Trial, Phase III
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

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Richards, D. A., Hughes-Morley, A., Hayes, R. A., Araya, R., Barkham, M., Bland, J. M., Bower, P., Cape, J., Chew-Graham, C. A., Gask, L., Gilbody, S., Green, C., Kessler, D., Lewis, G., Lovell, K., Manning, C., & Pilling, S. (2009). Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression--study protocol. BMC Health Services Research, 9(188). https://doi.org/10.1186/1472-6963-9-188

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abstract = "BACKGROUND: Comprising of both organisational and patient level components, collaborative care is a potentially powerful intervention for improving depression treatment in UK primary Care. However, as previous models have been developed and evaluated in the United States, it is necessary to establish the effect of collaborative care in the UK in order to determine whether this innovative treatment model can replicate benefits for patients outside the US. This Phase III trial was preceded by a Phase II patient level RCT, following the MRC Complex Intervention Framework.METHODS/DESIGN: A multi-centre controlled trial with cluster-randomised allocation of GP practices. GP practices will be randomised to usual care control or to {"}collaborative care{"} - a combination of case manager coordinated support and brief psychological treatment, enhanced specialist and GP communication. The primary outcome will be symptoms of depression as assessed by the PHQ-9.DISCUSSION: If collaborative care is demonstrated to be effective we will have evidence to enable the NHS to substantially improve the organisation of depressed patients in primary care, and to assist primary care providers to deliver a model of enhanced depression care which is both effective and acceptable to patients.",

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Richards, DA, Hughes-Morley, A, Hayes, RA, Araya, R, Barkham, M, Bland, JM, Bower, P, Cape, J, Chew-Graham, CA, Gask, L, Gilbody, S, Green, C, Kessler, D, Lewis, G, Lovell, K, Manning, C & Pilling, S 2009, 'Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression--study protocol', BMC Health Services Research, vol. 9, no. 188. https://doi.org/10.1186/1472-6963-9-188

TY - JOUR

T1 - Collaborative Depression Trial (CADET)

T2 - multi-centre randomised controlled trial of collaborative care for depression--study protocol

AU - Richards, David A

AU - Hughes-Morley, Adwoa

AU - Hayes, Rachel A

AU - Araya, Ricardo

AU - Barkham, Michael

AU - Bland, John M

AU - Bower, Peter

AU - Cape, John

AU - Chew-Graham, Carolyn A

AU - Gask, Linda

AU - Gilbody, Simon

AU - Green, Colin

AU - Kessler, David

AU - Lewis, Glyn

AU - Lovell, Karina

AU - Manning, Chris

AU - Pilling, Stephen

PY - 2009/10/16

Y1 - 2009/10/16

N2 - BACKGROUND: Comprising of both organisational and patient level components, collaborative care is a potentially powerful intervention for improving depression treatment in UK primary Care. However, as previous models have been developed and evaluated in the United States, it is necessary to establish the effect of collaborative care in the UK in order to determine whether this innovative treatment model can replicate benefits for patients outside the US. This Phase III trial was preceded by a Phase II patient level RCT, following the MRC Complex Intervention Framework.METHODS/DESIGN: A multi-centre controlled trial with cluster-randomised allocation of GP practices. GP practices will be randomised to usual care control or to "collaborative care" - a combination of case manager coordinated support and brief psychological treatment, enhanced specialist and GP communication. The primary outcome will be symptoms of depression as assessed by the PHQ-9.DISCUSSION: If collaborative care is demonstrated to be effective we will have evidence to enable the NHS to substantially improve the organisation of depressed patients in primary care, and to assist primary care providers to deliver a model of enhanced depression care which is both effective and acceptable to patients.

AB - BACKGROUND: Comprising of both organisational and patient level components, collaborative care is a potentially powerful intervention for improving depression treatment in UK primary Care. However, as previous models have been developed and evaluated in the United States, it is necessary to establish the effect of collaborative care in the UK in order to determine whether this innovative treatment model can replicate benefits for patients outside the US. This Phase III trial was preceded by a Phase II patient level RCT, following the MRC Complex Intervention Framework.METHODS/DESIGN: A multi-centre controlled trial with cluster-randomised allocation of GP practices. GP practices will be randomised to usual care control or to "collaborative care" - a combination of case manager coordinated support and brief psychological treatment, enhanced specialist and GP communication. The primary outcome will be symptoms of depression as assessed by the PHQ-9.DISCUSSION: If collaborative care is demonstrated to be effective we will have evidence to enable the NHS to substantially improve the organisation of depressed patients in primary care, and to assist primary care providers to deliver a model of enhanced depression care which is both effective and acceptable to patients.

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KW - Cooperative Behavior

KW - Cost-Benefit Analysis

KW - Depressive Disorder

KW - Family Practice

KW - Female

KW - Humans

KW - Male

KW - Patient-Centered Care

KW - Primary Health Care

KW - Randomized Controlled Trials as Topic

KW - United Kingdom

KW - Clinical Trial, Phase III

KW - Journal Article

KW - Multicenter Study

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.1186/1472-6963-9-188

DO - 10.1186/1472-6963-9-188

M3 - Article

C2 - 19832996

SN - 1472-6963

VL - 9

JO - BMC Health Services Research

JF - BMC Health Services Research

IS - 188

ER -

Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression--study protocol

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Keywords

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