Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

M. A. R. Ferreira; M. C. O'Donovan; Y. A. Meng; I. R. Jones; D. M. Ruderfer; L. Jones; J. Fan; G. Kirov; R. H. Perlis; E. K. Green; J. W. Smoller; D. Grozeva; I. Nikolov; K. Chambert; M. L. Hamshere; V. L. Nimgaonkar; V. Moskvina; M. E. Thase; S. Caesar; G. S. Sachs; J. Franklin; K. Gordon-Smith; K. G. Ardlie; S. B. Gabriel; C. Fraser; B. Blumenstiel; M. Defelice; G. Breen; M. Gill; D. W. Morris; A. Elkin; W. J. Muir; K. A. McGhee; R. Williamson; D. J. MacIntyre; A. W. MacLean; D. S. Clair; M. Robinson; M. Van Beck; A. C. P. Pereira; R. Kandaswamy; A. McQuillin; D. A. Collier; N. J. Bass; A. H. Young; J. Lawrence; I. N. Ferrier; A. Anjorin; A. Farmer; D. Curtis; E. M. Scolnick; P. McGuffin; M. J. Daly; A. P. Corvin; P. A. Holmans; D. H. Blackwood; H. M. Gurling; M. J. Owen; S. M. Purcell; P. Sklar; N. Craddock; Consor Wellcome Trust Case Control

doi:10.1038/ng.209

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

M. A. R. Ferreira, M. C. O'Donovan, Y. A. Meng, I. R. Jones, D. M. Ruderfer, L. Jones, J. Fan, G. Kirov, R. H. Perlis, E. K. Green, J. W. Smoller, D. Grozeva, I. Nikolov, K. Chambert, M. L. Hamshere, V. L. Nimgaonkar, V. Moskvina, M. E. Thase, S. Caesar, G. S. SachsJ. Franklin, K. Gordon-Smith, K. G. Ardlie, S. B. Gabriel, C. Fraser, B. Blumenstiel, M. Defelice, G. Breen, M. Gill, D. W. Morris, A. Elkin, W. J. Muir, K. A. McGhee, R. Williamson, D. J. MacIntyre, A. W. MacLean, D. S. Clair, M. Robinson, M. Van Beck, A. C. P. Pereira, R. Kandaswamy, A. McQuillin, D. A. Collier, N. J. Bass, A. H. Young, J. Lawrence, I. N. Ferrier, A. Anjorin, A. Farmer, D. Curtis, E. M. Scolnick, P. McGuffin, M. J. Daly, A. P. Corvin, P. A. Holmans, D. H. Blackwood, H. M. Gurling, M. J. Owen, S. M. Purcell, P. Sklar, N. Craddock, Consor Wellcome Trust Case Control

Research output: Contribution to journal › Article › peer-review

993 Citations (Scopus)

Abstract

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

Original language	Undefined/Unknown
Pages (from-to)	1056-1058
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	9
DOIs	https://doi.org/10.1038/ng.209
Publication status	Published - 2008

Access to Document

10.1038/ng.209

Cite this

Ferreira, M. A. R., O'Donovan, M. C., Meng, Y. A., Jones, I. R., Ruderfer, D. M., Jones, L., Fan, J., Kirov, G., Perlis, R. H., Green, E. K., Smoller, J. W., Grozeva, D., Nikolov, I., Chambert, K., Hamshere, M. L., Nimgaonkar, V. L., Moskvina, V., Thase, M. E., Caesar, S., ... Wellcome Trust Case Control, C. (2008). Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics, 40(9), 1056-1058. https://doi.org/10.1038/ng.209

@article{5f6a2f1fd78b4bcf98d06411a2e2dbef,

title = "Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder",

abstract = "To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.",

author = "Ferreira, {M. A. R.} and O'Donovan, {M. C.} and Meng, {Y. A.} and Jones, {I. R.} and Ruderfer, {D. M.} and L. Jones and J. Fan and G. Kirov and Perlis, {R. H.} and Green, {E. K.} and Smoller, {J. W.} and D. Grozeva and I. Nikolov and K. Chambert and Hamshere, {M. L.} and Nimgaonkar, {V. L.} and V. Moskvina and Thase, {M. E.} and S. Caesar and Sachs, {G. S.} and J. Franklin and K. Gordon-Smith and Ardlie, {K. G.} and Gabriel, {S. B.} and C. Fraser and B. Blumenstiel and M. Defelice and G. Breen and M. Gill and Morris, {D. W.} and A. Elkin and Muir, {W. J.} and McGhee, {K. A.} and R. Williamson and MacIntyre, {D. J.} and MacLean, {A. W.} and Clair, {D. S.} and M. Robinson and {Van Beck}, M. and Pereira, {A. C. P.} and R. Kandaswamy and A. McQuillin and Collier, {D. A.} and Bass, {N. J.} and Young, {A. H.} and J. Lawrence and Ferrier, {I. N.} and A. Anjorin and A. Farmer and D. Curtis and Scolnick, {E. M.} and P. McGuffin and Daly, {M. J.} and Corvin, {A. P.} and Holmans, {P. A.} and Blackwood, {D. H.} and Gurling, {H. M.} and Owen, {M. J.} and Purcell, {S. M.} and P. Sklar and N. Craddock and {Wellcome Trust Case Control}, Consor",

note = "Times Cited: 83",

year = "2008",

doi = "10.1038/ng.209",

language = "Undefined/Unknown",

volume = "40",

pages = "1056--1058",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Research",

number = "9",

}

Ferreira, MAR, O'Donovan, MC, Meng, YA, Jones, IR, Ruderfer, DM, Jones, L, Fan, J, Kirov, G, Perlis, RH, Green, EK, Smoller, JW, Grozeva, D, Nikolov, I, Chambert, K, Hamshere, ML, Nimgaonkar, VL, Moskvina, V, Thase, ME, Caesar, S, Sachs, GS, Franklin, J, Gordon-Smith, K, Ardlie, KG, Gabriel, SB, Fraser, C, Blumenstiel, B, Defelice, M, Breen, G, Gill, M, Morris, DW, Elkin, A, Muir, WJ, McGhee, KA, Williamson, R, MacIntyre, DJ, MacLean, AW, Clair, DS, Robinson, M, Van Beck, M, Pereira, ACP, Kandaswamy, R, McQuillin, A, Collier, DA, Bass, NJ, Young, AH, Lawrence, J, Ferrier, IN, Anjorin, A, Farmer, A, Curtis, D, Scolnick, EM, McGuffin, P, Daly, MJ, Corvin, AP, Holmans, PA, Blackwood, DH, Gurling, HM, Owen, MJ, Purcell, SM, Sklar, P, Craddock, N & Wellcome Trust Case Control, C 2008, 'Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder', Nature Genetics, vol. 40, no. 9, pp. 1056-1058. https://doi.org/10.1038/ng.209

TY - JOUR

T1 - Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

AU - Ferreira, M. A. R.

AU - O'Donovan, M. C.

AU - Meng, Y. A.

AU - Jones, I. R.

AU - Ruderfer, D. M.

AU - Jones, L.

AU - Fan, J.

AU - Kirov, G.

AU - Perlis, R. H.

AU - Green, E. K.

AU - Smoller, J. W.

AU - Grozeva, D.

AU - Nikolov, I.

AU - Chambert, K.

AU - Hamshere, M. L.

AU - Nimgaonkar, V. L.

AU - Moskvina, V.

AU - Thase, M. E.

AU - Caesar, S.

AU - Sachs, G. S.

AU - Franklin, J.

AU - Gordon-Smith, K.

AU - Ardlie, K. G.

AU - Gabriel, S. B.

AU - Fraser, C.

AU - Blumenstiel, B.

AU - Defelice, M.

AU - Breen, G.

AU - Gill, M.

AU - Morris, D. W.

AU - Elkin, A.

AU - Muir, W. J.

AU - McGhee, K. A.

AU - Williamson, R.

AU - MacIntyre, D. J.

AU - MacLean, A. W.

AU - Clair, D. S.

AU - Robinson, M.

AU - Van Beck, M.

AU - Pereira, A. C. P.

AU - Kandaswamy, R.

AU - McQuillin, A.

AU - Collier, D. A.

AU - Bass, N. J.

AU - Young, A. H.

AU - Lawrence, J.

AU - Ferrier, I. N.

AU - Anjorin, A.

AU - Farmer, A.

AU - Curtis, D.

AU - Scolnick, E. M.

AU - McGuffin, P.

AU - Daly, M. J.

AU - Corvin, A. P.

AU - Holmans, P. A.

AU - Blackwood, D. H.

AU - Gurling, H. M.

AU - Owen, M. J.

AU - Purcell, S. M.

AU - Sklar, P.

AU - Craddock, N.

AU - Wellcome Trust Case Control, Consor

N1 - Times Cited: 83

PY - 2008

Y1 - 2008

N2 - To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

AB - To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

U2 - 10.1038/ng.209

DO - 10.1038/ng.209

M3 - Article

SN - 1546-1718

VL - 40

SP - 1056

EP - 1058

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -