Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

M. A. R. Ferreira, M. C. O'Donovan, Y. A. Meng, I. R. Jones, D. M. Ruderfer, L. Jones, J. Fan, G. Kirov, R. H. Perlis, E. K. Green, J. W. Smoller, D. Grozeva, I. Nikolov, K. Chambert, M. L. Hamshere, V. L. Nimgaonkar, V. Moskvina, M. E. Thase, S. Caesar, G. S. SachsJ. Franklin, K. Gordon-Smith, K. G. Ardlie, S. B. Gabriel, C. Fraser, B. Blumenstiel, M. Defelice, G. Breen, M. Gill, D. W. Morris, A. Elkin, W. J. Muir, K. A. McGhee, R. Williamson, D. J. MacIntyre, A. W. MacLean, D. S. Clair, M. Robinson, M. Van Beck, A. C. P. Pereira, R. Kandaswamy, A. McQuillin, D. A. Collier, N. J. Bass, A. H. Young, J. Lawrence, I. N. Ferrier, A. Anjorin, A. Farmer, D. Curtis, E. M. Scolnick, P. McGuffin, M. J. Daly, A. P. Corvin, P. A. Holmans, D. H. Blackwood, H. M. Gurling, M. J. Owen, S. M. Purcell, P. Sklar, N. Craddock, Consor Wellcome Trust Case Control

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Abstract

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
Original languageUndefined/Unknown
Pages (from-to)1056-1058
Number of pages3
JournalNature Genetics
Volume40
Issue number9
DOIs
Publication statusPublished - 2008

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